We are not just talking about the ingredients that will help you sleep better tonight, but also what might be on the market in 2021. This is a list of 10 ingredients that can potentially improve your sleep. These 10 supplements have been proven to increase melatonin levels and promote deep REM (rapid eye movement) for those who need it!


With sales of melatonin supplements in 2020 is $536 million, melatonin is the undisputed “boss” of sleep aid products, but there are some safety concerns. Studies have found that excessive use may cause hormone imbalance and cerebral vasoconstriction problems, so foreign countries ban its sale to minors. The largest melatonin market share still belongs to it as a traditional ingredient; however, this percentage has been declining due in part, no doubt, because other ingredients such as valerian extract, ivy leaf extract, or 5-HTP also show promise for similar purposes without the side effects.” Natural botanical extracts are attracting a lot of attention as they have fewer side effects and are not addictive.


L-theanine is an amino acid compound and it is naturally found in green tea. It can also be made synthetically by combining glutamic acid, ethylamine hydrochloride, and ammonia with water. L-Theanine has been studied extensively for its mood-stabilizing benefits especially to improve sleep quality without any adverse side effects. The calming effect of this supplement ingredient does not result from sedating nor altering one’s consciousness but rather a relaxing sensation that allows the individual to experience better focus on their tasks at hand or during meditation sessions which last longer than usual when taking l-theanine supplements orally or topically applied as part of skincare regimen procedures like facials treatments.

L-Theanine has been scientifically proven to be effective in many areas and its safety is well recognized by several official bodies. With such wide uses, it can be found as a food additive or GRAS-certified products in the United States.


The Ashwagandha is a miraculous herb that has gained popularity in recent years. This plant, which originates from the Indian region of Ayurveda and Sanskrit for “smell leaf” or “horse smell” due to its distinctive fragrance, can help with both physical and emotional health issues. The most well-known use for this particular herb would be as an adaptogen; it helps your body adjust when you experience stress by providing natural energy boosts throughout the day without any harsh side effects like jitters or crashes. It also works wonders on improving sleep quality because it promotes healthy nighttime REM cycles while decreasing blood pressure levels during deep sleep hours so people don’t wake up feeling worn out!

Ashwagandha is very popular in the pre-workout market from helping with muscle gain to reducing stress. Ashwagandha contains tryptophan which helps convert into serotonin and melatonin in the brain- a hormone responsible for maintaining good health during sleep cycles by putting your body in relaxation mode so you feel sleepy before bedtime (this also helps people who suffer from insomnia). Especially when combined with other supplements or herbs like chamomile tea or valerian root, this supplement will help relieve any anxiety caused by lack of proper sleep and promote healthy slumber without reliance on drugs prescribed by doctors such as sleeping pills.

Ashwagandha is experiencing notable market growth of about 3395% in 2020.


Palmitoylethanolamide (PEA) is an endogenous fatty acid amide and has anti-inflammatory properties.

It’s found in food like animal offal, egg yolk, olive oil, and soy lecithin as well as peanuts which are legally recognized by some countries around the world.

Palmitoylethanolamide is experiencing notable market growth of about 3300% in 2020. How does palmitoylethanolamide help with sleep? What’s the mechanism of action for better sleep? Palmitoylethanolamide has been shown to be beneficial for people with insomnia and intermittent hypersomnia because it helps relieve anxieties that come from lack of proper sleep, promotes deep REM cycles, and provides relief from the symptoms of chronic pain or irritable bowel syndrome.

Palmitoylethanolamide has similar structures to CBD since they are both parts of the endogenous cannabinoid system(ECS). However, PEA helps to improve sleep conditions while CBD doesn’t have this ability but does help with anxiety disorders among other things due to it being part of the cannabinoid system that makes up our body’s endocannabinoids.

Saffron extract

Saffron, also known as Crocus sativus, is native to Iran, Spain, Greece and Asia Minor, and was introduced to China from Tibet in the middle of the Ming Dynasty. Saffron extract contains two active ingredients -Crocin and Safranal, which can promote the level of GABA and serotonin in the blood, thus regulating the balance between emotional substances, which in turn has the effect of improving sleep.

Black Seed extract

The black seed is a herbaceous flowering plant in the parsley family, which has been used as an ingredient for cooking and traditional medicines. It contains more than 100 different substances including minerals, vitamins, and antioxidants that can promote sleep quality.

Black seed extract contain compounds such as thymoquinone and thymol, which have high medicinal value. They can increase serotonin levels in the brain to reduce anxiety, improve mental energy levels and mood levels as well as sleep improvement. Thymoquinone regulates melatonin levels to help improve our natural circadian rhythm cycle, thus helping us fall asleep faster at night. Another way it does this is by improving blood circulation without causing drowsiness or lethargy during daytime hours.


alpha-casozepine is a bioactive decapeptide with a relaxing effect. In 2020, FDA approved its seven health claims, which include helping to improve the quality of sleep, helping to reduce stress, help fall asleep faster, and more.

Alpha casozepine has a specific affinity for certain receptors in the central nervous system, called GABAA receptors. It is this that increases the activity of gamma aminobutyric acid (GABA), which often inhibits anxiety and creates relaxing properties. Unlike benzodiazepines, it does not create any addiction at all – even when taken on high dosages!


Magnesium is an often forgotten mineral, but it plays a huge role in many different physiological reactions such as the synthesis of ATP. This essential nutrient helps regulate neurotransmitters and sleep patterns while also acting to relieve muscle tension or pain. With its increasing prevalence over recent years- according to data by Euromonitor International, Magnesium consumption has increased 11% from 2017-2020 due largely in part because magnesium deficiencies are rampant these days– this critical yet underutilized resource cannot be ignored any longer for those who want optimal health!

Some popular magnesium ingredients include Magnesium Glycinate, Magnesium Citrate, Magnesium glycerophosphate, and Magnesium L-Threonate. Magnesium L-Threonate is considered to be the most bioavailable form of magnesium and is a great choice for those who are looking for more than just sleep benefits.

In addition to the above mentioned sleep aid ingredients, GABA, tart cherry juice, sour date extract, probiotics, prebiotics, and fungal ingredient Xylaria nigripes are all ingredients to look forward to.

This list should not be used as medical advice: this article only contains what some experts feel will help provide better sleep in 2021– it does not imply that these ingredients are prescribed or medically recommended by health professionals.

It’s important to note that everyone has different needs when it comes to supplementation, which is why we’ve provided you with our top ten choices based on popularity and effectiveness!


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