What is Palmitoylethanolamide powder?
Palmitoylethanolamide powder, produced in the body, is a natural ingredient in the endogenous fatty acid amide category and is synthesized within your body. We call it endogenous. Palmitoylethanolamide pea powder is widely applied in sports nutrition supplements and joint health formulas worldwide, especially in the United States, Australia, the UK, Canada, and EU countries like the Netherlands, Belgium, and Italy.
Palmitoylethanolamide pea powder is a pretty long word. If it is your first time to come across it, you may wonder how to memorize or pronounce it. Well, palmitoylethanolamide is a word that consists of three words:
Palmitoyl / pɑːmɪ’tɔɪl/ +Ethanol / ‘eθənɔːl/ +Amide / ‘æmɪd/
In our daily life, PEA (the first letter of each of the three words) refers to palmitoylethanolamide for short. However, PEA is a plant, and PEA protein is also applied in bodybuilding supplements as a vegetarian source of protein content. Don’t get them wrong.
PEA has been demonstrated to bind to a receptor in the cell nucleus (a nuclear receptor) and exerts various biological functions related to chronic pain and inflammation.
Palmitoylethanolamide chemical properties
The IUPAC name of PEA is N-(2-Hydroxyethyl) hexadecanamide. Raw Palmitoylethanolamide is usually in powder form, with molecule formula and weight as C18H37NO2 and 299.49, respectively. 544-31-0 is Palmitoylethanolamide’s CAS Registry Number and unique chemical identity.
Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. Therefore, you may find that almost 99% of finished dosage formulations of palmitoylethanolamide are in capsules or soft gels.
Palmitoylethanolamide VS Phenylethylamine
In fact, they are two completely different ingredients. No relationship is between them. Phenylethylamine or Phenylethylamine HCl is most known as a mood and weight loss ingredient in many sports nutrition. While Palmitoylethanolamide powder is popularly known as a pain relief. The connection is that both compounds are abbreviated as PEA and called PEA powder. So don’t get them wrong.
Palmitoylethanolamide vs anandamide
Many of our clients who buy bulk palmitoylethanolamide powder are also interested in Bulk anandamide powder and anandamide oil from us. Therefore, what’s the relation between them?
Both Palmitoylethanolamide pea powder and anandamide are endogenous fatty acid amides in our human bodies.
According to Wikipedia, Palmitoylethanolamide PEA and related compounds such as anandamide seem to have synergistic effects in pain models.
In addition, the FAAH enzyme is able to break down both anandamide and palmitoylethanolamide in the body. If more PEA and AEA powder are added, it will take more time for FAAH to work and thus last longer positive effects.
Palmitoylethanolamide food sources
Some natural sources are found to contain Palmitoylethanolamide.
You may notice that soy lecithin, soybean, egg yolk, peanut (Arachis hypogaea), and Medicago sativa are among the top food sources. However, the calculated weight unit is ng/g (nanogram/gram). 6700 ng/g equals 6.7mg/kilo, meaning only 6.7mg PEA is in 1 kilo of soybean. The concentration of palmitoylethanolamide in natural foods is too low to meet our daily needs. All the market needs is bulk Palmitoylethanolamide, high in concentration and low in manufacturing cost. Cima Science is a bulk supplier of palmitoylethanolamide raw powder. If you have any questions regarding PEA, feel free to contact us.
Palmitoylethanolamide safety status
When discussing ingredient safety, you must check how the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) regulate palmitoylethanolamide pea powder. Of course, always consult with a qualified health physician before taking any new functional products.
Palmitoylethanolamide and FDA
Palmitoylethanolamide pea powder is marked as a dietary supplement ingredient in the United States. FDA has a flexible policy on dietary ingredients. Federal law does not require dietary supplements to be proven safe to FDA’s satisfaction before they are marketed. As long as the ingredient can be found in the human body’s metabolic process, palmitoylethanolamide pea powder is regarded as safe to be used.
Palmitoylethanolamide PEA naturally occurs in your body and can also be found in many food sources. It is safe to be supplemented to the body. More than 400 studies and clinical trials have been conducted; no serious side effects have been reported yet.
Moreover, there are hundreds of palmitoylethanolamide PEA supplements on sale on supplement stores Amazon, Vitamin Shoppe, iHerb, GNC, etc.
There are various PEA specifications available, such as powder form, topical cream, capsule, tablet, etc.
Our popular specs are powder forms. Well, there are two main sub-categories: normal PEA powder and micronized or ultra-micronized palmitoylethanolamide.
Both are food-grade and pharmaceutical-grade PEA powders that can be used in supplements and medicines directly. The difference lies in the particle size.
Micronized Palmitoylethanolamide powder has a particle size ranging from 2 to 6 microns (or μm). The normal PEA powder is about 80 mesh(which is equal to 180 microns. The micronized PEA is about 100 times smaller than the non-micronized PEA. Being micronized has much better bioavailability and gastroenteric absorption, and the micronized PEA powder has anti-caking properties and maintains stability at room temperature. That’s why so many clients prefer to use micronized Palmitoylethanolamide.
Where to buy Palmitoylethanolamide powder?
Cima Science is a professional manufacturer of bulk palmitoylethanolamide powder and is able to ship to every country by courier, by air, by sea, or by other means. Be aware that our product is in a raw ingredient package, and our website has no add-to-cart function. If you want to buy or purchase a bulk quantity, please contact us directly by email for more details.
Our micronized PEA powder has been tested by trusted and authoritative Third-Party Testing labs and organizations on purity, Heavy Metals, Residual Solvents, NMR spectrum, microorganism testing (Microbiology testing) and Oral Acute Toxicity Study of Palmitoylethanolamide
The purity (assay) of Palmitoylethanolamide tested by Advanced Botanical Consulting & Testing Inc.(ABC Testing. Inc) is 99.18%
The tested metals include Mercury (Hg), Lead (Pb), Arsenic (As), and Cadmium (Cd). Each content tested in the Eurofins confirms the standard of below 0.005 g/kg and 0.001g/kg, low than the standard requirement. According to Pony Testing International Group, none of the heavy metals is detected.
Palmitoylethanolamide Microbiology testing tested aerobic plate count and moulds & Yeast. Eurofins analytical report results are both less than 10 CFU/g.
The detailed testing reports in downloadable PDF forms are as below:
- Palmitoylethanolamide purity testing report by Advanced Botanical Consulting & Testing Inc
- Palmitoylethanolamide NMR spectrum
- Palmitoylethanolamide Powder Residual Solvents Pony Testing result
- Palmitoylethanolamide Microbiology testing Eurofins analytical report
- Palmitoylethanolamide heavy metals testing by Pony
- Palmitoylethanolamide heavy metals Eurofins analytical report
- Oral Acute Toxicity Study of Palmitoylethanolamide (SLX1253)+in+Rats(R)
What are our advantages of Cima PEA?
We receive 5-star feedback from clients who purchase micronized PEA powder from us in bulk quantity, and product quantity is available at a sample size from a milligram scale to 25kgs or 2 metric tons. A sample of more grams or kilos can be customized according to your demand.
Palmitoylethanolamide raw product is stable at room temperature. Store in a cool and dry place. Keep away from direct sunlight and re-seal the zipper immediately after use. KEEP OUT OF REACH OF CHILDREN. Do not use if the safety seal is broken or missing.
- Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis
- The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations
- Micronized ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
- Therapeutic benefit of palmitoylethanolamide in the management of neuropathic pain
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