What is Trigonelline?
Trigonelline (CAS 535-83-1), also known as niacin betaine, is a nitrogenous alkaline compound with the scientific name trimethyl xanthine. It is a white crystalline powder, soluble in methanol and water, with the IUPAC name 1-Methylpyridin-1-ium-3-carboxylate. Trigonelline Hydrochloride (CAS 6138-41-6) is a water-soluble trigonelline derivative with the molecular formula C7H8ClNO2 and a molecular weight of 173.60 g/mol.
Botanical sources of Trigonelline
Trigonelline naturally occurs in many plants. Trigonelline is a pyridine alkaloid primarily sourced from the leguminous plant fenugreek (Trigonella foenum-graecum). It is also found in coffee beans (higher level in arabica coffee), alfalfa, mulberry leaves, radishes, hemp seeds, soybeans, and other plants, as well as in mollusks, marine fish, and mammals. Coffee beans are the second major source of trigonelline after fenugreek. Currently, there are several methods for determining trigonelline content in coffee beans, including high-performance liquid chromatography (HPLC) and spectrophotometry.
Fenugreek, an annual herb from the legume family, originated in West Africa and now grows globally. India is a major producer. It’s cultivated mainly in China’s Three-North and South-Central regions, especially Anhui, Sichuan, and Henan. Fenugreek is used for cooking, medicine, nutrition, and weight management.
Trigonelline specifications
Trigonelline powder is available in various specifications to meet different needs. For lower concentrations, standardized options of 1%, 2%, and 5% are most popular, typically appearing as a yellowish-brown powder. Trigonelline is offered at up to 99% purity for ultra-pure applications, presenting as a white crystalline powder. Custom specifications are also available upon request. The 99% Trigonelline is increasingly popular among supplement brands as a novel NAD precursor for longevity and anti-aging. Commercial quantities are available—contact our sales team today for a wholesale quote.
Trigonelline vs NMN
Trigonelline, known as methylated niacin, plays a key role in niacin metabolism and is being explored for its potential as a promising new NAD+ precursor. Compared to other NAD+ precursors like nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), and NMNH powder, trigonelline has fewer research studies and applications currently. Main Trigonelline supplements on the market include fenugreek extract capsules and fenugreek capsules.
The “2024-2029 China Trigonelline Industry Market In-depth Research and Development Prospect Forecast Report” by New Industry Research Center highlights that trigonelline maintains high serum concentrations longer than NMN, with fewer side effects and better tolerance. While the global NMN market is expanding, its future is uncertain due to regulatory challenges, including the FDA’s ban on NMN as a dietary supplement. As a result, many supplement companies are exploring alternatives. Trigonelline is emerging as a promising NMN alternative, presenting significant market development opportunities.
Trigonelline Benefits
Trigonelline offers multiple health benefits, such as antioxidant effects, blood sugar control, and improved brain function. It also supports muscle strength and reduces cell damage. Recent studies suggest trigonelline may help fight gum disease and potentially influence serotonin levels. These properties make trigonelline valuable in medicines, cosmetics, foods, and health supplements.
Manufacturing Process
The manufacturing of trigonelline powder starts with selecting high-quality raw materials, usually fenugreek seeds or coffee beans. To isolate trigonelline, these materials undergo solvent extraction, typically methanol or water. The extracted solution is then filtered to remove impurities and concentrated to increase trigonelline content.
Next, the concentrated solution is cooled to crystallize trigonelline, which is then separated and purified, often through recrystallization, to achieve high purity levels. The purified crystals are dried, ground into a fine powder, and sieved for uniformity. Finally, the trigonelline powder undergoes quality control checks before being packaged for distribution.
trigonelline side effects
Trigonelline has not shown any serious adverse effects in studies so far; however, comprehensive safety data is still lacking due to the limited number of clinical trials. Further research is needed to understand its side effects fully.
Where to buy trigonelline bulk powder?
If you’re looking to buy trigonelline bulk powder, Wuxi Cima Science is your top choice. As a leading trigonelline bulk powder manufacturer and supplier in China, Wuxi Cima Science operates a state-of-the-art factory that produces high-purity trigonelline powder at 99% concentration. They also sell trigonelline supplements for sale, tailored to various needs.
In addition to its high-quality products, Wuxi Cima Science provides comprehensive OEM services, including private labeling, contract manufacturing, and multiple dosage forms such as powder, capsules, soft gels, and tablets. To ensure the highest standards, they offer third-party testing reports and free samples to test the quality before purchase. With their expertise in bulk powder production and a strong commitment to quality, Wuxi Cima Science is the trusted supplier for trigonelline supplements and bulk powder needs.
Contact us to get a wholesale quote now.
