What is TND-1128?
TND-1128 powder (CAS 59997-14-7), also known by systematic names such as 3-Methyl-10-ethyl-Deazaflavin or 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione and 3-methyl-10-ethyl-5-deazaflavin, is a synthetic deazaflavin analog (molecular formula C₁₄H₁₃N₃O₂; molecular weight 255.27 g/mol) with no botanical source. Produced to ≥99% purity by HPLC, it appears as a light yellow crystalline powder, exhibits excellent bioavailability for anti-aging and longevity applications, and is supplied in bulk in 25 kg drums. Cima Science is the leading ingredient supplier of bulk TND-1128 powder in China, offering not only this high-purity ingredient but also a comprehensive portfolio of longevity raw materials and turnkey OEM services, including capsules, tablets, and more.
TND-1128 VS 5-deazaflavin
TND-1128, a second-generation deazaflavin derivative, offers enhanced potency, improved bioavailability, longer half-life, and greater chemical stability compared to the original 5-deazaflavin, making it the superior choice for advanced anti-aging and longevity formulations.
| Attribute | TND-1128 (Second generation deazaflavin derivative) | 5-Deazaflavin (First generation deazaflavin) |
|---|---|---|
| CAS Number | 59997-14-7 | 26908-38-3 |
| Other Names (Synonyms) | TND-1128; 3-Methyl-10-ethyl-deazaflavin; 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4-dione | 5-Deazaflavin; Deazaflavin; NSC 106042; Pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione |
| Molecular Formula | C₁₄H₁₃N₃O₂ | C₁₁H₇N₃O₂ |
| Molecular Weight | 255.27 g/mol | 213.19 g/mol |
| Appearance | White crystalline powder | Off-white to pale yellow powder |
| Food Sources | None (fully synthetic) | None (fully synthetic) |
| Specifications | ≥ 99% (HPLC) | ≥ 98% (HPLC) |
| Purity | ≥ 99% | ≥ 98% |
| Bioavailability | High (optimized for absorption) | Moderate |
| Potency | High (enhanced sirtuin activation) | Moderate |
| Dosage | Typical: 50–150 mg/day | Typical: 100–200 mg/day |
| Half-Life | ~ 4–6 hours | ~ 2–4 hours |
| Stability | ≥ 2 years (room temp, dry) | ~ 1 year (room temp, dry) |
| Popularity | Emerging “second generation deazaflavin” in longevity R&D | Established first-generation flavin derivative |
| Pricing | Premium (~ \$300–500 per kg) | Cost-effective (~ \$25–30 per kg) |
| Main Benefits | Superior antioxidant, mitochondrial support, sirtuin activation | Antioxidant and NAD⁺-mimetic activity |
| Derivative Class | Second generation deazaflavin derivative | First generation deazaflavin |
3-Methyl-10-ethyl-deazaflavin Benefits
TND-1128 delivers powerful anti-aging and longevity support by targeting key cellular pathways involved in aging. As a second-generation deazaflavin derivative, it enhances SIRT1 activity and maintains NAD⁺ balance to promote DNA repair and chromatin stability. Its mitochondrial bioenergetics boosts ATP production while reducing oxidative stress, and its antioxidant and anti-inflammatory actions protect cells from damage. With superior bioavailability and stability, TND-1128 is an ideal ingredient for advanced longevity formulations.
Mechanism of Action
The anti-aging and longevity effects of TND-1128 and deazaflavin derivatives more broadly arise from several complementary mechanisms:
-
Sirtuin Activation
TND-1128 mimics NAD⁺ and directly enhances the activity of SIRT1 and other sirtuin enzymes, promoting chromatin remodeling, DNA repair, and stress resistance—hallmarks of cellular youthfulness. -
NAD⁺ Homeostasis & PARP Support
By acting as an NAD⁺ analog, it helps maintain intracellular NAD⁺ pools, supporting both sirtuins and PARP enzymes, which are critical for genome stability and efficient DNA damage repair. -
Mitochondrial Bioenergetics Enhancement
It facilitates electron transport chain function, particularly complex I, boosting ATP production and reducing mitochondrial reactive oxygen species (ROS) generation, thereby improving cellular energy metabolism and lowering oxidative stress. -
Potent Antioxidant & ROS Scavenging
The deazaflavin core structure enables direct free-radical quenching, protecting lipids, proteins, and DNA from oxidative damage accumulating with age. -
NRF2 Pathway Induction
TND-1128 upregulates NRF2 signaling, increasing transcription of endogenous antioxidant enzymes (e.g., HO-1, NQO1) to bolster the cell’s defense systems. -
Autophagy & Proteostasis Promotion
It modulates mTOR/AMPK pathways to stimulate autophagy, facilitating the removal of damaged organelles and aggregated proteins that otherwise impair cell function over time. -
Anti-inflammatory Effects
By inhibiting NF-κB activation and downstream cytokine release (e.g., TNF-α, IL-6), it reduces chronic low-grade inflammation (“inflammaging”) associated with tissue degeneration. -
Telomere Maintenance Support
Enhanced DNA repair and antioxidant protection indirectly slow telomere attrition rates, helping preserve the replicative capacity of stem and progenitor cells.
TND-1128 powder manufacturing process
- Multi-step controlled synthesis with premium precursors
- Advanced purification via column chromatography and recrystallization
- Rigorous quality testing (HPLC, NMR, mass spectrometry)
- Complete GMP compliance and batch documentation
- Consistent quality across all production runs
Where to buy TND-1128 bulk powder?
Looking for a reliable TND-1128 bulk powder manufacturer? Wuxi Cima Science Co., Ltd. is China’s leading wholesale supplier of high-purity TND-1128 and related compounds, including 5-deazaflavin. Our state-of-the-art manufacturing facility specializes in premium anti-aging and longevity ingredients for the global supplement market.
Why Choose Cima Science for Bulk TND-1128:
- Factory-direct pricing on wholesale quantities from kilograms to metric tons
- Consistent 99% purity with comprehensive third-party lab testing documentation
- Free samples available for qualified B2B buyers and supplement formulators
- Complete OEM services, including custom formulations and white-label solutions
- Specialized production of TND-1128 tablets and TND-1128 capsules for finished product manufacturers
- ISO-certified production facility with strict quality control protocols
- Flexible MOQ options for supplement brands of all sizes
As a vertically integrated second-generation deazaflavin derivative supplier, we offer complete supply chain transparency and technical support for your product development needs. Our in-house R&D team provides formulation assistance for incorporating TND-1128 into various supplement delivery systems.
Contact our international sales team today to request bulk pricing and COA documentation, or arrange your free sample of TND-1128 powder for evaluation. Discover why leading supplement brands trust Cima Science as their preferred longevity ingredient supplier in China.
