What is oxaloacetic acid?
Oxaloacetic acid (OAA) is a naturally occurring dicarboxylic acid that plays a crucial role in various biochemical processes, particularly in the citric acid cycle (Krebs cycle). Several other names, including 2-oxosuccinic acid and oxalosuccinic acid know it. The CAS number for Oxaloacetic acid is 328-42-7, and its molecular formula is C4H4O5. It has a molecular weight of 132.07 g/mol. This compound is primarily found in plants, particularly in the leaves of some species, such as spinach and rhubarb.
Regarding specifications, Oxaloacetic acid is typically available in a powder form, which is pale yellow to white in appearance and has a purity of 95% to 99%. Cima Science is the leading bulk Thermally Stabilized Oxaloacetic Acid Powder supplier in China, offering high-quality longevity ingredients for various applications.
oxaloacetic acid VS oxaloacetate
Oxaloacetic Acid is a precursor in the citric acid cycle, typically used in energy production and metabolic processes. It has a moderate bioavailability and potency but is less stable than Oxaloacetate. Oxaloacetate, the conjugate base, plays a more direct and stable role in cellular energy production and metabolism. It is more bioavailable and widely used in clinical applications and metabolic research. Though Oxaloacetate tends to be slightly more expensive, its higher stability, bioavailability, and potency make it a better option for specific applications, especially in therapeutic and clinical settings.
| Feature | Oxaloacetic Acid (OAA) | Oxaloacetate |
| CAS Number | 328-42-7 | 328-65-2 |
| Other Names | 2-Oxosuccinic acid, Oxalosuccinic acid | Oxaloacetate |
| Molecular Formula | C₄H₄O₅ | C₄H₄O₄ |
| Molecular Weight | 132.07 g/mol | 132.03 g/mol |
| Appearance | Pale yellow to white powder | White powder or crystalline form |
| Purity | Typically > 98% in industrial grade | Typically > 98% in industrial grade |
| Bioavailability | Moderate—converted to other metabolic intermediates in the body | High—directly involved in metabolic processes |
| Potency | Moderate—acts as a metabolic intermediate | High—direct participant in the citric acid cycle |
| Half-life | Short in circulation due to metabolic conversion | Short, rapidly converted in metabolism |
| Stability | Less stable than Oxaloacetate | More stable, especially in thermally stabilized forms |
| Popularity | Used in metabolic health and energy production | Widely studied for its role in energy metabolism |
| Pricing | Generally more affordable | It is slightly more expensive due to its stability and usage in medical formulations |
| Main Applications | Energy metabolism, antioxidant support | Energy production in cells, metabolic disorders treatment, research in enzyme activity |
Food Sources Rich in Oxaloacetic Acid
Oxaloacetic acid is a naturally occurring compound found in various foods, playing a vital role in energy metabolism. Although not directly consumed in large amounts from food, foods rich in oxaloacetic acid contain its precursor, oxaloacetate, which is involved in the citric acid cycle (Krebs cycle) and other essential metabolic processes. The body synthesizes oxaloacetic acid from other intermediates in food, particularly from high-quality, nutrient-dense options that support overall health.
Some of the best food sources rich in oxaloacetic acid and its precursor, oxaloacetate, include:
- Spinach: This leafy green is known for its high nutrient content, including oxaloacetate and oxaloacetic acid precursors, contributing to energy production and overall cellular health.
- Rhubarb: Another rich plant source of oxaloacetic acid, rhubarb contains high levels of organic acids, including oxalic acid, which is converted into oxaloacetate during metabolism.
- Beets: Beets are an excellent source of antioxidants and oxaloacetate, supporting energy metabolism and reducing oxidative stress.
- Carrots: Carrots are rich in beta-carotene and other antioxidants. They contain compounds that contribute to the synthesis of oxaloacetic acid and its role in cellular function.
- Avocados: A nutrient-packed fruit, avocados provide essential fats and antioxidants that support the formation of oxaloacetate and assist in the citric acid cycle.
- Tomatoes: A source of various vitamins and minerals, tomatoes are also known for their role in metabolic health, providing nutrients that help the body produce oxaloacetate.
Key Benefits of Oxaloacetic Acid Supplements:
Oxaloacetic acid supplements are becoming increasingly popular due to their potential health benefits, particularly in enhancing energy production, metabolic function, and antioxidant defense. As a key player in the citric acid cycle (Krebs cycle), oxaloacetic acid is essential for generating ATP, the body’s primary energy source. For individuals looking to support their cellular health, mental clarity, or overall vitality, these supplements can be an effective addition to their wellness routine.
Key Benefits of Oxaloacetic Acid Supplements:
- Boosts Energy Levels: Oxaloacetic acid supplements help increase energy at the cellular level by promoting ATP production, supporting muscle function, physical endurance, and overall vitality.
- Supports Metabolic Health: These supplements can assist in metabolic regulation, helping the body efficiently process carbohydrates and fats for optimal weight management and energy utilization.
- Promotes Mental Clarity: Oxaloacetic acid supplements support brain function, potentially enhancing focus, memory, and cognitive performance.
- Antioxidant Properties: Oxaloacetic acid acts as an antioxidant, helping neutralize harmful free radicals and protect cells from oxidative damage, contributing to long-term health.
- Detoxification Support: Supplements may aid the body’s natural detox processes, particularly supporting liver health and the elimination of toxins.
Oxaloacetic Acid Powder Manufacturing Process
The manufacturing process of Oxaloacetic Acid powder involves a precise series of steps using chemical synthesis to achieve a final product with a purity of 95% minimum. This method ensures high-quality oxaloacetic acid suitable for applications in energy metabolism, supplementation, and various biotechnological processes.
1. Chemical Synthesis
The process begins with chemical synthesis, where specific precursors are subjected to controlled reactions, often involving catalysts and reagents, to form oxaloacetic acid. This synthetic pathway is optimized to produce high-purity oxaloacetic acid efficiently.
2. Purification
After synthesis, the crude product undergoes rigorous purification to eliminate impurities such as unreacted chemicals, solvents, and by-products. Techniques like solvent extraction, chromatography, and crystallization isolate pure oxaloacetic acid.
3. Stabilization
Once purified, the oxaloacetic acid is thermally stabilized to ensure its effectiveness and longevity. This step prevents degradation and ensures the compound remains stable during storage and usage, maintaining its bioactivity and purity.
4. Drying and Powder Formation
The stabilized oxaloacetic acid undergoes a drying process, typically spray drying or freeze-drying, to remove residual moisture. This results in a fine, free-flowing powder that is easy to handle, store, and transport.
5. Quality Control and Testing
The final oxaloacetic acid powder is subjected to stringent quality control tests to verify that it meets the required 95% minimum purity. Additional tests include checks for particle size, solubility, stability, and the absence of contaminants such as heavy metals and residual solvents.
6. Packaging
Once quality checks are passed, the oxaloacetic acid powder is carefully packaged in airtight containers to prevent contamination and maintain the product’s integrity. This packaging ensures that the product remains stable and pure until it reaches its end user.
Where to buy bulk Oxaloacetic Acid Powder?
If you want to purchase bulk oxaloacetic acid powder, Cima Science is the leading manufacturer in China. We offer high-quality oxaloacetic acid at wholesale prices. With a production capacity of 20 tons per month, we are well-equipped to meet large-scale demands for industries requiring food-grade oxaloacetic acid ingredients.
At Cima Science, we prioritize quality and customer satisfaction. Our bulk oxaloacetic acid powder is chemically synthesized to ensure a minimum purity of 95%, making it suitable for various applications, including metabolic health, biochemistry, and supplementation. We also offer free samples to help you evaluate the product before purchasing.
Cima Science is an ideal source for businesses or research institutions seeking competitive pricing and reliable delivery. Whether you need a small sample or a large bulk order, we are here to provide the best solutions for your needs.
Get a Quote Now and secure your premium oxaloacetic acid powder supply at wholesale prices. Contact Cima Science today and take advantage of our industry-leading capabilities and service.






