What is 5-deazaflavin?
5-deazaflavin powder is a pyridopyrimidine compound derived from flavin, also known as vitamin B2. It is created by replacing the aza group, which contains a nitrogen N element, at position 5 with a deaza substitution, which contains a carbon C element.
This unique deaza substitution enables the 5-deazaflavin backbone to function similarly to the vitamin B3 backbone, NMN/NAD+. Interestingly, the vitamin B2 backbone is chemically stable, and 5-deazaflavin has multiple substituents that can be converted.
There are ten conversion patterns at each of the three sites, which allows for as many as 1000 adaptations. Of all the possible adaptations, the best overall improved version was named TND1128.
The adaptability of 5-deazaflavin and the potential of its derivatives, such as TND1128, make it an exciting compound for further research and development. Its ability to function similarly to NMN/NAD+ and its adaptability to be converted in various ways could have a wide range of applications in different fields, such as longevity medicine and energy production.
5-deazaflavin VS NMN
5-Deazaflavin and NMN (Nicotinamide Mononucleotide) are known for their potential aging and longevity benefits. These benefits are attributed to their ability to increase the levels of NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme involved in various biological processes, including cellular energy production and DNA repair.
NMN has to Convert to NAD+ to Work, but Deazaflavin Works Directly
NMN converts into NAD+ within the cells, supporting cellular functions and counteracting age-related decline. However, this conversion process may be less efficient than direct NAD+ supplementation.
On the other hand, 5-Deazaflavin acts directly without the need for conversion. This property may give it an advantage in potency and efficiency compared to NMN.
Research indicates that 5-Deazaflavin is about 40 times more effective than NMN.
Deazaflavin Powder Manufacturing Process
In order to manufacture 5-deazaflavin powder, the synthesized deazaflavin molecules are subjected to controlled conditions and processes to obtain the powdered form. These processes include milling and sieving, ensuring consistent particle size distribution, and maintaining sterility and purity of the final product.
While the exact steps and equipment used in producing the powder may differ between manufacturers, the underlying process principles remain the same – converting the synthesized deazaflavin molecules into a fine powder that can be used in various applications.
Benefits of 5-deazaflavin supplements
As a next-generation NMN (nicotinamide mononucleotide), 5-deazaflavin shows potential in anti-aging for its unique properties and benefits.
Some research suggests that 5-deazaflavin may have immune-boosting properties, potentially helping to support a healthy immune system.
In addition, 5-deazaflavin has been used in an anticancer agent as an active ingredient in a Japanese patent.
Where to Buy Deazaflavin Powder in Bulk?
Cima Science is a company specializing in producing and distributing natural ingredients, including various chemicals for research, development, and manufacturing. There are several benefits to purchasing 5-deazaflavin bulk powder from Cima Science:
- 98% pure: The deazaflavin powder provided by Cima Science is 98% pure, ensuring you get a high-quality product for your applications.
- 25kg/drum package: Cima Science offers a convenient 25kg/drum package, making it an ideal option for bulk purchasing.
- Bulk quantity: By providing bulk quantities of deazaflavin powder, Cima Science can meet the demands of different customers, from researchers to manufacturers.
- Free sample: If you want to try the product before committing to a larger purchase, Cima Science offers the possibility to request a free sample of their 5-deazaflavin bulk powder.
Get a wholesale price now by filling out the form or contacting us directly.
5-deazaflavin Literature reference
- CHEN, X., TANAKA, K., & YONEDA, F. (1990). A new synthetic approach to 5-deazaflavin and 5-deaza-10-thiaflavin. In Chemical and Pharmaceutical Bulletin (Vol. 38, Issue 3, pp. 612–615). Pharmaceutical Society of Japan. https://doi.org/10.1248/cpb.38.612
- Takahashi, N., Akaike, N., Nagamatsu, T., Uchino, H., & Kudo, Y. (2023). Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN. In Journal of Pharmacological Sciences (Vol. 151, Issue 2, pp. 93–109). Elsevier BV. https://doi.org/10.1016/j.jphs.2022.11.005
- TANAKA, K., KIMURA, T., OKADA, T., CHEN, X., & YONEDA, F. (1987). Synthesis of chiral 5-deazaflavin derivatives and their use in asymmetric reduction of ethyl benzoylformate. In Chemical and Pharmaceutical Bulletin (Vol. 35, Issue 4, pp. 1397–1404). Pharmaceutical Society of Japan. https://doi.org/10.1248/cpb.35.1397
- Coenzyme Modeis 17. Is 5-Deazaflavin a Model for NAD+ ? Comment on the Deviation from Linear Free-energy Relationships
- US7498336B2 – Deazaflavin compounds and methods of use thereof – Google Patents. (2003, February 13). US7498336B2 – Deazaflavin Compounds and Methods of Use Thereof – Google Patents. https://patents.google.com/patent/US7498336B2/fr
- JP2884170B2 – Anticancer agent containing 5-deazaflavin compound as active ingredient – Google Patents. (1989, August 24). JP2884170B2 – Anticancer Agent Containing 5-deazaflavin Compound as Active Ingredient – Google Patents. https://patents.google.com/patent/JP2884170B2/en?q=(Deazaflavin)&oq=Deazaflavin
- JPH0673058A – 5-deazaflavin derivative and its production – Google Patents. (1992, August 26). JPH0673058A – 5-deazaflavin Derivative and Its Production – Google Patents. https://patents.google.com/patent/JPH0673058A/en?q=(Deazaflavin)&oq=Deazaflavin
