What is Ca AKG?
Ca AKG is the short form of Calcium Alpha-Ketoglutarate powder, a combination of calcium and salt of alpha-ketoglutaric acid that plays a significant role in energy metabolism and cellular health. Its CAS number is 71686-01-6, and its molecular formula is C5H4CaO5, with a molecular weight of approximately 184.16 g/mol.
CA-AKG powder typically appears as a fine, white to off-white powder, reflecting its high purity and suitability for supplementation. Ca-AKG is widely recognized for its potential benefits, including supporting healthy aging, promoting energy production by enhancing the Krebs cycle, and improving bone health due to its calcium content. Additionally, it may assist in reducing oxidative stress and supporting overall cellular repair mechanisms.
Food Sources
Calcium Alpha-Ketoglutarate (Ca AKG) is not naturally occurring in its salt form but is synthesized by combining calcium with alpha-ketoglutaric acid (AKG), a naturally occurring compound in the human body. AKG plays a central role in cell metabolism and physiology as a critical intermediate in the Krebs (citric acid) cycle, essential for cellular energy production. This biological substance is involved in the oxidation of glucose, amino acids, and fatty acids and serves as a precursor for synthesizing glutamine and glutamate. While AKG is naturally present in the body, it is not found in significant amounts in food, making it accessible primarily through dietary supplements. The calcium salt form, Ca AKG, is manufactured synthetically and is commonly used in supplements to support energy metabolism, bone health, and overall cellular function.
Calcium Alpha-Ketoglutarate specifics
Ca-AKG is available in 99% pure powder form and is readily in stock. Other forms, such as capsules, soft gels, and tablets, can be customized to meet your specific requirements.
Mechanism of Calcium Alpha Ketoglutarate
Calcium Alpha-Ketoglutarate (Ca AKG) supports longevity and anti-aging by influencing cellular energy metabolism, reducing oxidative stress, and promoting cellular repair. AKG is a key intermediate compound involved in the Krebs cycle, ensuring efficient energy production to maintain cellular vitality as we age. It also acts as an antioxidant, neutralizing free radicals and minimizing oxidative damage, a major contributor to aging. Additionally, AKG modulates signaling pathways and epigenetic markers linked to aging processes, helping to reduce inflammation and support tissue regeneration. These mechanisms make Ca AKG a powerful tool for promoting healthy aging and extending cellular lifespan.
CAAKG Manufacturing Process
The manufacturing process of 99% pure Calcium Alpha-Ketoglutarate (Ca AKG) powder begins with synthesizing alpha-ketoglutaric acid (AKG) through chemical oxidation or microbial fermentation. The AKG is then reacted with a calcium salt, such as calcium hydroxide or calcium carbonate, in a controlled neutralization process to form Ca AKG. The resulting product is purified through filtration or crystallization to ensure high purity. It is then dried to remove moisture and milled into a fine powder. Rigorous quality control, including HPLC or NMR testing, ensures the final product meets 99% purity standards before packaging.
Certificate of Analysis(COA)
Please contact us to get the latest batch of COA for CA-AKG.
Calcium-AKG Benefits, Side Effects
Calcium-AKG is used as a dietary supplement for various benefits:
- Healthy Aging Support: Ca AKG, a stable form of Alpha-Ketoglutarate, promotes healthy aging by slowing age-related DNA methylation changes and reducing inflammation caused by senescent cells, supporting overall cellular health.
- Mitochondrial Function: Ca AKG enhances metabolic function, providing energy for vital cellular processes. It also stimulates collagen and protein synthesis, contributing to mitochondrial health and overall vitality.
- Lifespan Extension: Research indicates that Ca AKG can significantly extend lifespan and healthspan, as demonstrated in animal studies, by lowering systemic inflammatory cytokines and improving cellular function.
- Support for Bodybuilding: Ca AKG aids in protein metabolism, enhances energy production, and promotes collagen synthesis, supporting muscle growth, recovery, and overall athletic performance.
Where to buy Calcium AKG bulk powder?
Cima Science is your trusted supplier in China if you’re looking for wholesale calcium Alpha-Ketoglutarate (Ca AKG) bulk powder. As a leading Ca AKG manufacturer, Cima Science offers premium-quality products backed by extensive expertise and state-of-the-art manufacturing facilities. With 10 tons of 99% pure Ca AKG powder in stock, we are ready to meet your bulk purchasing needs promptly.
Ca AKG bulk powder is a dietary supplement ingredient that is rigorously tested to ensure high purity and quality, with a third-party quality test report available for verification. We also provide flexible OEM services, including capsules, tablets, blister packaging, and powder blending, catering to your specific formulation requirements. Additionally, our products are certified with internationally recognized standards, including Halal, Kosher, and ISO9001, ensuring compliance with global quality and safety standards.
Whether you’re searching for Ca AKG for sale from a reliable factory or need a custom solution, Cima Science is equipped to deliver excellence. Partner with us for competitive pricing, consistent supply, and superior customer service in manufacturing high-quality calcium Alpha-Ketoglutarate supplements.
FAQs
How bioavailable is CAAKG compared to a liposomal formulation?
Calcium Alpha-Ketoglutarate (CaAKG) offers good bioavailability in its standard form, efficiently supporting cellular metabolism. However, liposomal Ca AKG significantly enhances absorption using lipid-based vesicles to protect the compound and improve uptake. This makes liposomal formulations more effective for delivering maximum anti-aging and longevity benefits.
Alpha-ketoglutarate VS Calcium Alpha-ketoglutarate
Alpha-ketoglutarate (AKG) is a key compound in energy metabolism, supporting cellular health and longevity. Calcium Alpha-Ketoglutarate (Ca-AKG) combines AKG with calcium, offering added benefits for bone health and energy support. Ca-AKG is ideal for those seeking anti-aging and skeletal support in one supplement.
Calcium Alpha-Ketoglutarate VS Alpha-Ketoglutaric Acid
Calcium Alpha-Ketoglutarate (Ca AKG) combines Alpha-Ketoglutaric Acid (AKG) with calcium, offering energy metabolism, anti-aging, and bone health benefits. AKG focuses solely on cellular energy and metabolic support, while Ca AKG provides added calcium for skeletal health.
References
- Asadi Shahmirzadi, A., Edgar, D., Liao, C.-Y., Hsu, Y.-M., Lucanic, M., Asadi Shahmirzadi, A., Wiley, C. D., Gan, G., Kim, D. E., Kasler, H. G., Kuehnemann, C., Kaplowitz, B., Bhaumik, D., Riley, R. R., Kennedy, B. K., & Lithgow, G. J. (2020). Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. In Cell Metabolism (Vol. 32, Issue 3, pp. 447-456.e6). Elsevier BV. https://doi.org/10.1016/j.cmet.2020.08.004
- Yu, H., Gan, D., Luo, Z., Yang, Q., An, D., Zhang, H., Hu, Y., Ma, Z., Zeng, Q., Xu, D., & Ren, H. (2024). α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice. In Molecular Medicine (Vol. 30, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s10020-024-00783-1
- Legendre, F., MacLean, A., Appanna, V. P., & Appanna, V. D. (2020). Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite. In World Journal of Microbiology and Biotechnology (Vol. 36, Issue 8). Springer Science and Business Media LLC. https://doi.org/10.1007/s11274-020-02900-8
