What is Sialic acid
Sialic Acid is a group of derivatives of neuraminic acid (N- or O-substituted derivatives neuraminic acid). Usually in the form of oligosaccharides, glycolipids or glycoproteins.
Sialic Acid is also the name for this group’s most common member – N-acetylneuraminic acid (Neu5Ac or NANA).
Sialic acid family
It has been known for nearly 50 members, all derivatives of the negatively charged 9-carbon sugar neuraminic acid.
N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic
acid (Neu5Gc) and deaminoneuraminic acid (KDN) are its core monomer.
N-acetylneuraminic acid is the only kind of Sialic Acid in our body.
Sialic Acid and Bird’s nest
Because Sialic acid is rich in bird’s nest, it is also called bird’s nest acid, which is an essential indicator of bird’s nest grading.
Sialic Acid is the main nutrition ingredients in Bird’s nest, around 3%-15% by weight.
Among all the known foods, Bird’s nest contains the highest content of Sialid acid, around 50 times higher than other foods.
1g Bird’s nest equals 40 eggs if we get the same quantity of Sialic Acid.
Sialic Acid food sources
Generally, plants contain no Sialic acid. The leading supply of Sialic acid is human milk, meat, egg, and cheese.
Contents of total Sialic acid in conventional foods (µg/g or µg/ml).
| Raw food sample | Neu5Ac | Neu5Gc | Total | Neu5Gc, % of total |
| Beef | 63.03 | 25.00 | 88.03 | 28.40 |
| Beef fat | 178.54 | 85.17 | 263.71 | 32.30 |
| Pork | 187.39 | 67.49 | 254.88 | 26.48 |
| Lamb | 172.33 | 97.27 | 269.60 | 36.08 |
| Ham | 134.76 | 44.35 | 179.11 | 24.76 |
| Chicken | 162.86 | 162.86 | ||
| Duck | 200.63 | 200.63 | ||
| Egg white | 390.67 | 390.67 | ||
| Egg yolk | 682.04 | 682.04 | ||
| Salmon | 104.43 | 104.43 | ||
| Cod | 171.63 | 171.63 | ||
| Tuna | 77.98 | 77.98 | ||
| Milk (2% Fat 3% Pr) | 93.75 | 3.51 | 97.26 | 3.61 |
| Butter | 206.87 | 206.87 | ||
| Cheese | 231.10 | 17.01 | 248.11 | 6.86 |
| Human milk | 602.55 | 602.55 |
We can see that the Sialic acid in Human milk is high, which is the key ingredient for a baby’s brain development.
But Sialic Acid content is different in different Periods Human milk
Breast milk colostrum 1300 +/- 322 mg/l
10 days later 983 +/- 455 mg/l
Preterm infant milk powder 197 +/- 31 mg/l
Adapted milk formulas 190 +/- 31 mg/l
Partially adapted milk formulas 100 +/- 33 mg/l
Follow-up milk formulas 100 +/- 33 mg/l
Soy-based milk formulas 34 +/- 9 mg/l
Compared with Breast milk, Infant milk powder contains around 20% Sialic acid from Human milk, while the baby can only get 25% Sialic acid from Breast milk.
For a Preterm baby, Sialic acid is more essential than a healthy baby in Brain development.
Sialic Acid Study on Milk powder
“The results indicated that brain sialic acid content plays an important role in determining behavior. Another group observed improved learning with free sialic acid treatment in rodents.”
CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition, and Natural
Resources 2006 1, No. 018， Is sialic acid in milk food for the brain?， Bing Wang
“The Conclusion is Higher brain ganglioside and glycoprotein sialic acid concentrations in infants fed human milk suggests increased synaptogenesis and differences in neurodevelopment.”
Am J Clin Nutr 2003;78:1024–9. Printed in the USA. © 2003 American Society for Clinical Nutrition，Brain ganglioside, and glycoprotein sialic acid in breastfed compared with formula-fed infants， Bing Wang
“Neural cell membranes contain 20 times more sialic acid than other types of membranes, indicating that sialic acid has a clear role in neural structure.”
The European Journal of Clinical Nutrition, (2003) 57, 1351–1369, The role and potential of sialic acid in human nutrition, Bing Wang
N-Acetylneuraminic acid Application
Milk Powder
Currently, More and more Breastfeeding mothers’ milk powder, Babies’ Milk powder, and Nutritional supplements contain Sialic Acid on the Market.
For Breastfeeding Mothers
For Baby Milk powder 0-12 months
For Healthcare product
For Beverage
Since Sialic acid has a good water-soluble ability, many companies are trying to development Sialic acid beverages for Brain health or add into milk products.
N-Acetylneuraminic acid Safety
N-Acetylneuraminic acid is very safe. Currently, no negative news reported on Sialic acid.
The USA, China, and EU governments approve Sialic acid to be used in Food and Health care products.
USA
In 2015, N-Acetyl-D-neuraminic acid (Sialic acid) was determined Generally Recognized as Safe (GRAS)
China
In 2017, China Government approved N-Acetylneuraminic acid as a New Resource Food Ingredient.
EU
Safety of synthetic N-acetyl-d-neuraminic acid as a novel food under Regulation (EC) No 258/97
On 16 October 2015, orphan designation (EU/3/12/972) was granted by the European Commission to Ultragenyx UK Limited, United Kingdom, for sialic acid (also known as aceneuramic acid) for treatment of GNE myopathy.
Scientific Opinion on the substantiation of health claims related to sialic acid and learning and memory (ID 1594) pursuant to Article 13(1) of Regulation (EC) No 1924/2006
Dosage
CFDA suggest 500mg/day
Novel food suggests 55mg/day for Infant and 220mg/day for Young and middle-aged women
N-acetylneuraminic acid Function
Memory and Intelligence improvement
By interacting with brain cell membranes and synapses, Sialic acid increases the response rate of synapses in the brain’s nerve cells, thereby promoting the development of memory and intelligence.
New Zealand scientists have done a series of experiments to confirm the critical role of bird’s nest acid in children’s intellectual development. Finally, the researchers concluded that supplementing bird’s nest acid in infants could increase the concentration of bird’s nest acid in the brain, thereby improving the brain’s ability to learn.
Improve intestinal absorption capacity
According to the simple physical phenomenon of the opposite sex, the positively charged minerals and some vitamins that enter the intestine are easily combined with the strong negatively charged bird’s nest acid, so the intestinal absorption of vitamins and minerals. The ability has been enhanced from it.
Promote intestinal antibacterial detoxification
Sialic Acid on the cell membrane protein plays a crucial role in improving cell recognition ability, detoxification of cholera toxin, prevention of pathological Escherichia coli infection, and regulation of blood protein half-life.
Longevity
Sialic acid has a protective and stabilizing effect on cells, and the lack of sialic acid can lead to a decrease in blood cell life and a decrease in glycoprotein metabolism.
Develop new medicine for Sialic Acid
Scientists try to treat gastrointestinal diseases with sialic acid anti-adhesion drugs. Sialic acid anti-adhesive drugs can treat Helicobacter pylori to treat gastric ulcers and duodenal ulcers.
Sialic acid is a glycoprotein. It determines the mutual recognition and binding of cells and has clinically similar anti-inflammatory effects as aspirin.
Sialic acid is a drug for central or topical neurological diseases and demyelinating diseases; sialic acid is also a cough expectorant.
Sialic acid as a raw material can develop a series of essential sugar drugs, anti-virus, anti-tumor, anti-inflammatory, and treatment of senile dementia have outstanding results.
The production process of Sialic Acid
The starting raw materials are mainly glucose, corn steep liquor,glycerinum, and magnesium sulfate. And we use fermented technology. During this process, we use the way of sterilization to keep the materials clean. Then by hydrolysis, concentration, drying, and smashing. After all the processes, we get the final product. And our QC will use HPLC to test the material quality for every batch before we deliver it to the clients.
Where to buy Sialic Acid Powder?
CIMA SCIENCE was established in 2010. And with over 10 years’ good development, we have owned a huge factory with various products. And the qualification certificates we have such as ISO22000, KOSHER, HALAL, etc….
And our main market areas are in North America, European Union & some other countries. For free samples & quotations, please freely contact us at any time.
Frequently Asked Questions
Could you offer Sialic Acid powder in bulk?
Yes, CIMA has sufficient stocks of SA powder to meet the quality requirements of customers and arrange the delivery in the fastest time.
What aspects does Cima Science test for SA Powder?
Usually, we test the assay, water content, Identification by NMR, Heavy metals.
Residual solvents, Microbes also meet customers’ other requests if necessary.
Do you have MOQ for this product?
No, we don’t have any MOQ requirements. The clients could order from grams to KG.
How to make an order?
We can make the shipments by FedEx immediately for small orders because we always have regular stocks. And for large orders, we also can ensure the shipment time.
The payment terms are negotiable. We can do FOB, CIF, and DDP by Air or by Sea.
