What is Sialic acid
Sialic Acid is a group of derivatives of neuraminic acid (N- or O-substituted derivatives neuraminic acid). Usually in the form of oligosaccharides, glycolipids or glycoproteins.
Sialic Acid is also the name for this group’s most common member – N-acetylneuraminic acid (Neu5Ac or NANA).
Sialic acid family
It has been known for nearly 50 members, all derivatives of the negatively charged 9-carbon sugar neuraminic acid.
N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic
acid (Neu5Gc) and deaminoneuraminic acid (KDN) are its core monomer.
N-acetylneuraminic acid is the only kind of Sialic Acid in our body.
Sialic Acid and Bird’s nest
Because Sialic acid is rich in bird’s nest, it is also called bird’s nest acid, which is an essential indicator of bird’s nest grading.
Sialic Acid is the main nutrition ingredients in Bird’s nest, around 3%-15% by weight.
Among all the known foods, Bird’s nest contains the highest content of Sialid acid, around 50 times higher than other foods.
1g Bird’s nest equals 40 eggs if we get the same quantity of Sialic Acid.
Sialic Acid food sources
Generally, plants contain no Sialic acid. The leading supply of Sialic acid is human milk, meat, egg, and cheese.
Contents of total Sialic acid in conventional foods (µg/g or µg/ml).
| Raw food sample | Neu5Ac | Neu5Gc | Total | Neu5Gc, % of total |
| Beef | 63.03 | 25.00 | 88.03 | 28.40 |
| Beef fat | 178.54 | 85.17 | 263.71 | 32.30 |
| Pork | 187.39 | 67.49 | 254.88 | 26.48 |
| Lamb | 172.33 | 97.27 | 269.60 | 36.08 |
| Ham | 134.76 | 44.35 | 179.11 | 24.76 |
| Chicken | 162.86 | 162.86 | ||
| Duck | 200.63 | 200.63 | ||
| Egg white | 390.67 | 390.67 | ||
| Egg yolk | 682.04 | 682.04 | ||
| Salmon | 104.43 | 104.43 | ||
| Cod | 171.63 | 171.63 | ||
| Tuna | 77.98 | 77.98 | ||
| Milk (2% Fat 3% Pr) | 93.75 | 3.51 | 97.26 | 3.61 |
| Butter | 206.87 | 206.87 | ||
| Cheese | 231.10 | 17.01 | 248.11 | 6.86 |
| Human milk | 602.55 | 602.55 |
We can see that the Sialic acid in Human milk is high, which is the key ingredient for a baby’s brain development.
But Sialic Acid content is different in different Periods Human milk
Breast milk colostrum 1300 +/- 322 mg/l
10 days later 983 +/- 455 mg/l
Preterm infant milk powder 197 +/- 31 mg/l
Adapted milk formulas 190 +/- 31 mg/l
Partially adapted milk formulas 100 +/- 33 mg/l
Follow-up milk formulas 100 +/- 33 mg/l
Soy-based milk formulas 34 +/- 9 mg/l
Compared with Breast milk, Infant milk powder contains around 20% Sialic acid from Human milk, while the baby can only get 25% Sialic acid from Breast milk.
For a Preterm baby, Sialic acid is more essential than a healthy baby in Brain development.
The production process of Sialic Acid
The starting raw materials are mainly glucose, corn steep liquor,glycerinum, and magnesium sulfate. And we use fermented technology. During this process, we use the way of sterilization to keep the materials clean. Then by hydrolysis, concentration, drying, and smashing. After all the processes, we get the final product. And our QC will use HPLC to test the material quality for every batch before we deliver it to the clients.
Where to buy Sialic Acid Powder?
CIMA SCIENCE was established in 2010. And with over 10 years’ good development, we have owned a huge factory with various products. And the qualification certificates we have such as ISO22000, KOSHER, HALAL, etc….
And our main market areas are in North America, European Union & some other countries. For free samples & quotations, please freely contact us at any time.
Frequently Asked Questions
Could you offer Sialic Acid powder in bulk?
Yes, CIMA has sufficient stocks of SA powder to meet the quality requirements of customers and arrange the delivery in the fastest time.
What aspects does Cima Science test for SA Powder?
Usually, we test the assay, water content, Identification by NMR, Heavy metals.
Residual solvents, Microbes also meet customers’ other requests if necessary.
Do you have MOQ for this product?
No, we don’t have any MOQ requirements. The clients could order from grams to KG.
How to make an order?
We can make the shipments by FedEx immediately for small orders because we always have regular stocks. And for large orders, we also can ensure the shipment time.
The payment terms are negotiable. We can do FOB, CIF, and DDP by Air or by Sea.
