What is Alpha GPC?
Alpha-GPC is a member of the phospholipid family, as one of the phosphatidylcholine derivatives, playing an important role in the health of cell membranes.
The mainly physiological function of Alpha-GPC is to cross the blood-brain barrier and provide the necessary choline for the biosynthesis of acetylcholine and phosphatidylcholine.
Alpha-GPC is known for its effects on brain health, attention, concentration, and memory generation.
why do we choose Alpha-GPC, not Beta-GPC?
Beta-glycerylphosphocholine(Beta-GPC) is also a member of phosphocholines.
Beta-GPC contributes very little to total GPC(~1%), while Alpha-GPC is hydrolyzed to phosphorylcholine and contributes to the supply of choline needed by the liver and choline needed for myelin synthesis.
How Does Alpha GPC work?
When the human body absorbs Alpha-GPC, it is decomposed into choline and glycerophosphate under the action of enzymes in the body. Among them, choline participates in the biosynthesis of acetylcholine, which is a kind of neurotransmitter; glycerophosphate is lecithin Derivatives, involved in the synthesis of lecithin.
The main pharmacological effects of Alpha-GPC include protecting the metabolism of choline; ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation; improving cognitive and behavioral responses in patients with traumatic brain capillaries.
Alpha-GPC VS CDP Choline(Citicoline) VS Phosphatidylserine
From the source, Alpha-GPC can be obtained naturally from soybean lecithin, or it can be made by synthetic route; CDP Choline is mainly synthetic route; phosphatidylserine (PS) can be obtained from soybean lecithin, sunflower lecithin, etc.
In terms of efficacy, CDP Choline is mainly used as a brain metabolism and neuroactivator, which can promote brain cell respiration, improve brain function, enhance the function of the activation system of the ascending reticular structure, promote recovery, and reduce cerebrovascular resistance; Phosphatidylserine also It is called compound nervonic acid, which is an active substance of cell membrane. Its effect is to improve the function of nerve cells, regulate the conduction of nerve impulses, and enhance the memory function of the brain. Because of its strong lipophilicity, it can quickly enter the brain through the blood-brain barrier after absorption, soothe vascular smooth muscle cells and increase blood supply to the brain.
The three materials mentioned above are known for their cognitive benefits such as supporting memory, mental performance, and focus.
Our Alpha-GPC specifications
Alpha GPC 50 powder 25kg/Drum
Alpha GPC 50% granule 25kg/Drum
Alpha GPC liquid 85% 25kg/Drum
Alpha GPC powder 99% 1kg/Bag 25kg/Drum
Alpha-GPC softgel/Alpha-GPC capsule/Alpha-GPC tablet
Alpha-GPC Clinical trials
The following chart is the Clinical trial’s details of Alpha-GPC:
|NCT01363648||The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia||Phase 4||Completed||2013-10-14|
|NCT02395926||To Evaluate Safety and the Pharmacokinetic Characteristics After Oral Administration of HT-003 Compared With Choline Alfoscerate Capsule in Healthy Adult Male Volunteers||Phase 1||Completed||2015-03-24|
|NCT02648906||A Clinical Trial for an Evaluation of Choline Alfoscerate and Donepezil for Cognitive Improvements of Patients With Cerebrovascular Injury in Alzheimer’s Patients||Phase 4||Unknown status||2016-11-02|
|NCT03249259||The Effect of Choline Alfoscerate on Improvement of Cognitive Function in Elderly Patients With Diabetes||Phase 3||Completed||2019-10-08|
|NCT03228498||Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment||Phase 2||Completed||2020-01-13|
|NCT05050604||A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate in Vascular Cognitive Impairment Patients||Phase 4||Not yet recruiting||2021-09-20|
|NCT05041790||A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate Compared to Placebo in Patients With Degenerative Mild Cognitive Impairment||Phase 4||Not yet recruiting||2021-09-20|
|NCT05257902||Clinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory Complaints||N/A||Not yet recruiting||2022-02-25|
|NCT05383183||Efficacy and Safety of Choline Alfoscerate in Patients With Mild to Moderate Alzheimer’s Disease||Phase 4||Recruiting||2022-05-20|
What are the Benefits of taking Alpha GPC?
Alpha-GPC is a widely used nootropic supplement, main benefits include:
Protect brain health
We all know that Alpha GPC is a precursor to acetylcholine, which enhances cholinergic transmission in the brain. Specifically through the mechanism of action Alpha GPC directly increases the synthesis and secretion of acetylcholine, better than any other choline-related compound, affecting choline concentrations system-wide and in the brain.
Alpha GPC can counteract brain aging by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural changes in the brain.
Alpha GPC also works to improve mental performance and improve memory and learning by counteracting the age-related loss of nerve cells and fibers in the brain.
High doses (1200 mg) of Alpha-GPC are effective in mild to moderate Alzheimer’s disease and work well with standard therapy (acetylcholinesterase inhibitors).
Boost muscle and athletic performance
Some preliminary evidence shows that Alpha GPC has the ability to support healthy brain function and the release of somatotrophin (hGH). it also is able to enhance acute growth hormone production and power output during exercise. Increased growth hormone production and power output can increase muscle mass and improve overall metabolic activity, thereby enhancing muscle and athletic performance.
Studies also report that slightly higher single doses of 600mg-800mg may be more beneficial when Alpha GPC is taken before exercise (such as a pre-workout supplement).
In summary, Alpha-GPC has two main functions:
- Central effect: improve dementia; improve learning ability; inhibit the secretion of stress hormones
- Peripheral effect: promote growth hormone secretion; improve liver function; immunity and repair ability during injury.
In the field of medicine, Alpha-GPC preparations are mainly oral preparations (capsules, tablets). According to statistics, the global GPC preparation market size in 2020 is about 347 million US dollars. Companies like DAEWOONG, CHONG KUN DANG, ITALFARMACO, etc
In the field of health products, mainly dietary supplements. According to statistics, the global market size of Alpha-GPC-containing health products in 2020 is about 105 million US dollars, Famous brands such as Doctor’s Best, Now Food, etc
Alpha-GPC Main Countries Regulations：
Alpha-GPC has the status of ‘Generally Recognized as Safe’ (GRAS) as an ingredient in beverages and foods when consumed at a level not to exceed 196.2 mg/person/day.
In Europe, Alpha GPC is a prescription-strength synthesized medication that is given to Alzheimer’s patients in 1,200 mg doses.
In Korea, Alpha GPC(Choline alfoscerate) is included in Korean Pharmacopoeia (KPC).
Typically, we see that in many brands of GPC supplements, the recommended dosage is 300-600 mg, but for different symptoms and users, a 400-1200mg daily dosage is also suitable.
Why buy Alpha-GPC bulk powder from Cima Science？
Cima Science began to develop this product in 2002-2003 and successfully produced it at a large scale. At present, natural Alpha-GPC can also be commercially produced with a capacity of 100 tons every year.
Cimasci owned several specifications of Alpha-GPC, including some special specifications and different forms:
- Alpha-GPC 50% Ordinary Powder, Alpha-GPC 85% Liquid, Alpha-GPC 99% Powder
- Alpha-GPC 50% non-hygroscopic granular
- Alpha -GPC Softgels
- Alpha-GPC +NMN powder patented formula
1. GMP, SMF, and DMF Available;
2. The only Non-hygroscopic GPC in China;
3. Third-party inspection;
5. OEM service.
If you want to try using Alpha-GPC in your supplement formula, please contact the Cima sales team for a quotation, you’ll get a reply immediately.
1. Q: Are you a manufacturer, trading company, or a third party?
A: We are a manufacturer, and we have built up our company since 2002.
2. Q: Is it a synthetic or Nature resource?
A: we’re able to manufacture both synthetic and natural alpha gpc powders.
3. Q: Do you have a USA warehouse?
A: Yes, we have a warehouse in California and tons of inventory.
4. Q: What payment terms do you have? accept?
A: 100% T/T or West Union.