What is Paraxanthine?
Paraxanthine powder(1,7-dimethylxanthine), also known by its IUPAC name 1,7-Dimethyl-3H-purine-2,6-dione and CAS number 611-59-6, is a metabolite of caffeine and a central nervous system (CNS) stimulant. It is a white crystalline powder that offers cleaner, smoother energy than caffeine. As a nootropic, the key benefits of Paraxanthine include enhanced focus and mental clarity, making it a popular ingredient in cognitive and energy supplements.
paraxanthine vs. caffeine
Paraxanthine, a caffeine alternative, offers all the benefits of caffeine without the negative side effects. Without jitters or crashes, it is great for both men and women who want to boost their pre-workout productivity and avoid burnout, with consistent and stable boosting effects.
The table below highlights the differences between caffeine and Paraxanthine, demonstrating how Paraxanthine offers more consistent and beneficial effects with fewer drawbacks than caffeine.
| Aspect | Caffeine | Paraxanthine |
| Effectiveness | It doesn’t work well for most; effectiveness varies widely. | Works for nearly everyone; consistent and reliable effects. |
| Tolerance | Users often build a tolerance, requiring increased dosing over time. | Offers a consistent response with a consistent dose. |
| Mood and Confidence | Can leave users feeling agitated and anxious. | Enhances mood and confidence. |
| Focus and Concentration | Can be overstimulating or “jittery.” | Improves focus and concentration. |
| Hunger | Increases feelings of hunger. | Reduces feelings of hunger. |
| Dependence | Risk of habituation and dependence. | No habituation or dependence. |
| Sleep Impact | Negatively impacts sleep quality and quantity. | Lifts mood/energy without impacting sleep. |
| Desensitization | Desensitization occurs with continued use, reducing efficacy. | Works consistently without diminishing returns. |
| Toxicity and Cleanliness | More toxic, less “clean,” and associated with more side effects. | Less toxic, cleaner, and safer with fewer side effects. |
Paraxanthine specifications
The certificate of analysis (COA) of paraxanthine for sale is as follows:
| Product and Batch Information | |||
| Product Name: | 1,7-Dimethylxanthine | Country of Origin: | P.R. China |
| CAS No.: | 611-59-6 | Molecular Weight: | 180.16 |
| Molecular Formula: | C7H8N4O2 | Batch: | CS-PA-240418 |
| Manufacture Date: | Apr 18, 2024. | Expiry Date: | Apr 17, 2026. |
| Item | Specification | Result | Test Method |
| Active Ingredients | |||
| Assay(%,On Dried Base) | NLT98.0% | 99.00% | HPLC |
| Purity | NLT98.0% | 99.40% | HPLC |
| Physical Control | |||
| Appearance | Fine Powder | Complies | Visual |
| Color | White | Complies | Visual |
| Identification | Positive | Complies | NMR |
| Residual on Ignition | NMT 0.50% | 0.07% | USP |
| Loss on drying | NMT 1.0% | 0.32% | USP |
| Chemical Control | |||
| Heavy metals | NMT 10PPM | Conforms | Atomic Absorption |
| Arsenic(As) | NMT 1PPM | Conforms | Atomic Absorption |
| Lead(Pb) | NMT 2ppm | Conforms | Atomic Absorption |
| Cadmium(Cd) | NMT 2ppm | Conforms | Atomic Absorption |
| Mercury(Hg) | NMT 1ppm | Conforms | Atomic Absorption |
| Solvents Residue | Meeting USP Standard | Conforms | Gas Chromatography |
| Microbiological Control | |||
| Total Plate Count | 10,000cfu/g Max | Conforms | AOAC |
| Yeast & Mold | 300cfu/g Max | Conforms | AOAC |
| E.Coli | Negative/10g | Negative | AOAC |
| Salmonella | Negative/25g | Negative | AOAC |
| Staph Aureus | Negative/10g | Negative | AOAC |
| Packing and Storage | |||
| Packing | Pack in paper drums and two plastic bags inside. 25kg/drum. | ||
| Storage | Store in a well-closed container away from moisture and direct sunlight. | ||
| Shelf Life | 2 years if sealed and stored properly. | ||
Paraxanthine raw material’s standard specification and purity is 98%min, and the actual testing result is up to 99% pure. If you need other technical documents such as MOA (method of analysis), MSDS(material safety data sheet), nutritional fact data, or tiered pricing on different quantities, please contact us by submitting the form inquiry.
Paraxanthine Benefits
Paraxanthine provides sustained energy, enhanced focus, and wakeful clarity. It boosts mood and well-being, protects cognitive function, improves reaction time, and reduces mental errors. It also increases calorie burn and thermogenesis. With fewer side effects and reduced toxicity compared to caffeine, paraxanthine offers consistent results without crashes or anxiety.
Paraxanthine Side effects
Paraxanthine, a next-gen caffeine alternative, offers consistent energy and focus without the jitters, anxiety, crashes, or sleep issues associated with traditional caffeine, making it a superior choice for those seeking the benefits of caffeine without the side effects.
Paraxanthine Manufacturing Process
Commercially Available Paraxanthine Powder (99% Purity) is produced through a precise synthesis, purification, and quality control process. The process begins with caffeine or other xanthines, which are chemically converted into paraxanthine (1,7-dimethylxanthine) using methylating agents like methyl iodide and sodium hydroxide (NaOH) in solvents such as acetone. The methyl group is removed to yield paraxanthine.
The resulting crude mixture undergoes solvent extraction and silica gel chromatography for purification. The purified paraxanthine is recrystallized, dried using vacuum, freeze, or air drying methods, and then milled into a fine powder. The final product is a white crystalline powder with a minimum purity of 98%.
Quality control includes HPLC testing to ensure purity, potency, and safety before packaging. This process guarantees high-quality paraxanthine powder with 99% purity, ideal for dietary supplements, research, and other applications.
Where to buy Paraxanthine in bulk?
Cima Science is a wholesale manufacturer of 98% pure bulk paraxanthine powder for sale, which has been third-party tested for purity. With 10 tons in stock, competitive wholesale pricing, free samples, and OEM services, we ensure availability for large orders. Our paraxanthine powder is produced in a GMP-compliant, USP-standard factory and offers superior quality and reliability. Cima offers pure paraxanthine powder at wholesale prices, making it a great option for those looking to buy this coffee alternative for clean energy, focus, and cognition. Contact us to get a wholesale quote now!
Reference：
- Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. In Journal of the International Society of Sports Nutrition (Vol. 18, Issue 1). Informa UK Limited. https://doi.org/10.1186/s12970-020-00383-4
- Jäger, R., Purpura, M., Wells, S. D., Liao, K., & Godavarthi, A. (2022). Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. In Nutrients (Vol. 14, Issue 4, p. 893). MDPI AG. https://doi.org/10.3390/nu14040893
- Yoo, C., Xing, D., Gonzalez, D., Jenkins, V., Nottingham, K., Dickerson, B., Leonard, M., Ko, J., Faries, M., Kephart, W., Purpura, M., Jäger, R., Wells, S. D., Sowinski, R., Rasmussen, C. J., & Kreider, R. B. (2021). Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial. In Nutrients (Vol. 13, Issue 11, p. 3980). MDPI AG. https://doi.org/10.3390/nu13113980
