Magnesium glycinate (CAS 14783-68-7), also called magnesium diglycinate or magnesium bisglycinate, is a chelated form of magnesium in which one Mg²⁺ ion is bound to two glycine molecules. This “magnesium and glycinate” pairing yields a highly stable, gentle-on-the-stomach powder prized in the dietary-supplement industry for its superior absorption and minimal gastrointestinal side effects.
In the realm of high-purity supplement ingredients, magnesium glycinate (CAS No. 14783-68-7) possesses the molecular formula C₄H₈MgN₂O₄ and a molecular weight of 172.42 g/mol. As a premium glycine chelate, it delivers 14.1% elemental magnesium by mass, ensuring superior stability and bioavailability that integrates seamlessly into your next-generation formulation pipelines for capsules, tablets, and powder blends.
Specifications
At Wuxi Cima Science Co., Ltd., our magnesium glycinate specifications are engineered to meet the most demanding B2B supplement applications: we supply a liposomal magnesium glycinate powder with ≥98% purity of glycine chelate (14.1% elemental magnesium) encapsulated in phospholipid micelles for ultra-high bioavailability; consumer-friendly magnesium glycinate gummies delivering 100–500 mg elemental Mg per serving in a vegan pectin or gelatin matrix with natural fruit flavors; and versatile liquid suspensions offering up to 500 mg elemental Mg per 10 mL in aqueous glycerin or MCT oil vehicles, pH-balanced and temperature-stable. Through our custom OEM services, we support you from tailored formulation development and pilot-scale trials to private-label packaging (sachets, bottles, drums), full QA documentation (COA, MSDS, GMP, ISO, Halal/Kosher), and ongoing R&D collaboration—ensuring turnkey magnesium glycinate solutions that streamline your product development and time to market.
Magnesium glycinate vs citrate
Magnesium glycinate is generally better for those seeking gentle supplementation with fewer digestive side effects and better sleep support. Meanwhile, magnesium citrate offers superior value for addressing constipation and for those on a budget. Your optimal choice depends primarily on your specific health needs, digestive sensitivity, and intended therapeutic benefits.
Between the two, magnesium glycinate generally edges out magnesium citrate for long-term mineral supplementation thanks to its higher elemental magnesium content (14.1% vs. 11.33%), superior absorption as an amino-acid glycine chelate, and minimal gastrointestinal side effects. While still well-absorbed and more economical, magnesium citrate often exerts a mild laxative effect, making it better suited for occasional use or digestive support rather than daily, high-dose formulations.
| Feature | Magnesium Glycinate | Magnesium Citrate |
|---|---|---|
| CAS Number | 14783-68-7 | 3344-18-1 |
| Other Names | Magnesium bisglycinate, magnesium diglycinate | Magnesium citrate tribasic, trimagnesium citrate |
| Molecular Formula | C₄H₈MgN₂O₄ | C₆H₆MgO₇ |
| Molecular Weight | 172.43 g/mol | 214.41 g/mol |
| Appearance | White crystalline powder | White crystalline powder or granules |
| Food Sources | Not naturally found in foods (synthetic form) | Small amounts in citrus fruits |
| Elemental Magnesium Content | 14-18% | 16-18% |
| Purity Standards | USP, FCC grade available | USP, FCC grade available |
| Bioavailability | High (up to 80%) | Moderate to high (65-75%) |
| Potency | Moderate | Moderate to high |
| Typical Dosage | 200-400 mg (elemental Mg), 1-3 times daily | 200-400 mg (elemental Mg), 1-2 times daily |
| Half-life | Approximately 4-6 hours | Approximately 3-5 hours |
| Stability | Very stable in supplements | Stable, but can degrade in high humidity |
| Popularity | High among those seeking gentle supplementation | Very high, widely used |
| Average Pricing | Higher ($0.25-0.50 per dose) | Lower ($0.10-0.30 per dose) |
| Main Benefits | • Gentle on digestive system • Superior sleep support • Good for anxiety reduction • Less likely to cause diarrhea • Better for long-term daily use |
• Effective laxative effect • Better for constipation • Higher absorption rate • More budget-friendly • Good for occasional use |
| Side Effects | Minimal digestive discomfort | Can cause diarrhea, abdominal cramps |
| Best For | Sleep issues, anxiety, sensitive digestion, regular use | Constipation, magnesium deficiency, budget concerns |
| Taste | Less bitter, more palatable | More bitter, often flavored in liquid forms |
| Form Availability | Capsules, tablets, powder | Capsules, tablets, powder, liquid |
| Medical Applications | Anxiety, insomnia, muscle relaxation, migraines | Constipation, bowel prep, indigestion |
| Supplement Interactions | Fewer interactions with other supplements | May reduce absorption of certain medications |
Magnesium glycinate vs magnesium l-threonate
Magnesium L-threonate is the only form of magnesium proven to increase brain magnesium levels significantly. It is the superior choice for cognitive enhancement, memory improvement, and potential neuroprotective benefits in age-related cognitive decline. Magnesium L-threonate can cross the blood-brain barrier with remarkable efficiency. Meanwhile, magnesium glycinate remains the gentler, more versatile option for everyday supplementation. It offers excellent bioavailability without digestive distress, making it ideal for addressing general magnesium deficiency, sleep quality, muscle recovery, and stress management. While L-threonate focuses on brain health at a premium price point (typically $30-45 monthly), glycinate provides broad-spectrum benefits at a more moderate cost ($15-25 monthly). Your choice between these high-quality supplements should align with whether cognitive optimization or general wellness is your primary goal.
Magnesium Bisglycinate Powder Manufacturing Process
Magnesium Glycinate Benefits
- Promotes restful sleep (magnesium glycinate sleep): Its chelated glycine structure helps regulate GABA and relax muscles, supporting deeper, more restorative slumber.
- Eases anxiety (magnesium glycinate anxiety): Highly bioavailable glycine chelate calms the nervous system without sedative drawbacks, helping to reduce mild anxiety symptoms.
- Supports women’s health (magnesium glycinate benefits for women): Studied for alleviating pregnancy-induced leg cramps, offering safe, targeted support for expectant mothers.
- Clinical applicability: Evaluated in patients after bowel resection, demonstrating effective absorption even with compromised gastrointestinal function.
- Gentle digestive support (magnesium glycinate for constipation): Not a primary laxative, but its mild action can help maintain regularity without the strong GI effects of other forms.
- Safe during pregnancy (magnesium glycinate pregnancy): Low risk of gastrointestinal side effects and high tolerability make it a preferred choice for maternal mineral supplementation
Where to buy magnesium glycinate bulk powder?
Looking for magnesium glycinate in bulk? Cima Science is China’s top manufacturer, offering direct factory pricing and a minimum purity of 98%.
Our modern facility handles everything from kilograms to metric tons. We keep pricing competitive for wholesale orders.
Need documentation? You’ll get COA, MSDS, and third-party testing reports with every order. For businesses, we even send free samples so you can check the quality firsthand.
Want something unique? We can create custom specifications for your specific formulations. Our GMP-compliant manufacturing process keeps batch quality consistent.
International shipping? That’s no problem. We’ve got export logistics support covered.
Quality Assurance Guaranteed
Each shipment comes with full documentation to back up our quality. You’ll receive a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and detailed heavy metal testing reports.
We also include microbial analysis verification for extra peace of mind.
Request Your Bulk Quote Today
Need wholesale pricing on magnesium glycinate powder? Reach out to our international sales team with your quantity and specs.
Shoot us an email and lock in manufacturer-direct pricing. Take a step toward strengthening your supply chain with China’s top magnesium glycinate factory.
Want to see the quality for yourself? Request a free sample and a confidential bulk quote. Get a taste of superior quality at real wholesale prices.
References
- Schuette, S. A., Lashner, B. A., & Janghorbani, M. (1994). Bioavailability of Magnesium Diglycinate vs Magnesium Oxide in Patients with Ileal Resection. Journal of Parenteral and Enteral Nutrition, 18(5), 430–435. https://doi.org/10.1177/0148607194018005430
- Supakatisant, C., & Phupong, V. (2012). Oral magnesium for relief in pregnancy‐induced leg cramps: a randomised controlled trial. Maternal & Child Nutrition, 11(2), 139–145. https://doi.org/10.1111/j.1740-8709.2012.00440.x
- Ates, M., Kizildag, S., Yuksel, O., Hosgorler, F., Yuce, Z., Guvendi, G., Kandis, S., Karakilic, A., Koc, B., & Uysal, N. (2019). Dose-Dependent Absorption Profile of Different Magnesium Compounds. Biological Trace Element Research, 192(2), 244–251. https://doi.org/10.1007/s12011-019-01663-0
- Cheung, M. M., Dall, R. D., Shewokis, P. A., Altasan, A., Volpe, S. L., Amori, R., Singh, H., & Sukumar, D. (2022). The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial. Nutrition, 99–100, 111674. https://doi.org/10.1016/j.nut.2022.111674
