What is tributyrin?
Tributyrin, also known as glyceryl tributyrate, tri-n-butyrylglycerol, or butanoic acid 1,2,3-propanetriyl ester (CAS 60-01-5), is a triglyceride formed by esterification of glycerol with three butyric acid molecules and is naturally present in dairy fats and certain plant oils such as shea and cocoa butter. It has the molecular formula C₁₅H₂₆O₆ and a molecular weight of 302.36 g/mol.
Cima Science’s bulk tributyrin meets a ≥ 99 % purity specification by HPLC, ensuring ultra-high quality. In liquid form, it appears as a clear to pale-gold oil and in powder form as a fine white to off-white powder, offering excellent flow and handling. Tributyrin supplements deliver high bioavailability through the rapid release of butyric acid in the gastrointestinal tract. Tributyrin ingredient is supplied in 25 kg drums or 200 kg HDPE drums for bulk supplement formulas. Cima Science is the leading bulk tributyrin liquid supplier in China and also offers oil and powdered tributyrin raw ingredients and OEM services for capsules, softgels, and other customized dosage forms.
Food-Grade Tributyrin VS Feed-Grade Tributyrin
Food-grade and feed-grade tributyrin share the same basic chemistry (glyceryl tributyrate) but are formulated, certified, and packaged to meet different end-use requirements. Cima Science’s Food Grade Tributyrin is tailored for human dietary supplements and nutraceuticals, with ultra-high purity, strict microbial limits, and certifications such as FDA GRAS and EU Novel Food compliance. Feed Grade Tributyrin, by contrast, is optimized for animal nutrition, often a lower-purity, cost-effective ingredient with feed-additive approvals (e.g., AAFCO) and broader impurity tolerances. Below is a side-by-side comparison of their key attributes:
| Feature | Food-Grade Tributyrin | Feed-Grade Tributyrin |
|---|---|---|
| Purity (GC) | ≥ 99.0% (typically 99 to 99.9%) | ≥ 90% (often 90 to 95%) |
| Regulatory Standards | FDA GRAS, EU Novel Food, USP/NF monographs; Kosher, Halal options | AAFCO, national feed additive regulations; SGS feed testing |
| Typical Applications | Dietary supplements (capsules, softgels), functional foods | Poultry, swine and aquaculture feeds; premix blends |
| Microbial Limits | Total plate count ≤ 1,000 CFU/g; absence of pathogens | Total plate count ≤ 10,000 CFU/g; broader tolerance |
| Moisture Content | ≤ 0.2% | ≤ 0.5% |
| Acid Value | ≤ 0.1 mg KOH/g | ≤ 0.5 mg KOH/g |
| Peroxide Value | ≤ 2 meq O₂/kg | ≤ 5 meq O₂/kg |
| Appearance & Odor | Clear to pale-gold liquid; virtually odorless | Pale-gold liquid; mild characteristic odor |
| Shelf Life | 24 months (sealed, ≤ 25 °C) | 12 to 18 months (sealed, ambient storage) |
| Packaging Options | 25 kg or 180 kg HDPE or steel drums; IBC totes (1,000 kg) | 180 kg steel drums; 1 MT IBC totes; bulk tanker shipments |
| Pricing Tier | Premium (reflecting high-purity testing and certifications) | Economical (volume-driven, lower testing overhead) |
| Typical Order Size | ≥ 100 kg | ≥ 500 kg |
Tributyrin vs Butyrate
Tributyrin is a triglyceride-based butyrate precursor that releases natural butyrate deeper in the colon through enzymatic conversion in the gut. Unlike sodium butyrate, which often has taste issues and is absorbed too early, tributyrin offers enhanced liquid butyrate potency and stability as a pre-butyrate, delivering postbiotic butyrate to your colon faster. Found naturally in tributyrin foods such as dairy fats and plant oils, it provides a clean-label approach to boosting colonic butyrate levels. For formulators seeking superior delivery, tributyrin’s slow release profile and high bioavailability make it the ideal choice over conventional butyrate salts.
Key Benefits of Tributyrin
Tributyrin is a potent postbiotic and probiotic precursor that delivers natural butyrate directly to your colon. It supports healthy weight management, enhances gut health, and relieves constipation. Its slow-release liquid butyrate potency makes tributyrin weight loss support more effective than conventional salts, while its targeted delivery boosts intestinal barrier integrity and promotes regularity.
- Weight Loss: tributyrin weight loss supports, boosts fat oxidation, and helps regulate appetite for a healthier body composition.
- Gut Health: Tributyrin for gut health acts as a postbiotic and probiotic, nourishing beneficial bacteria and strengthening the intestinal barrier.
- Constipation Relief: tributyrin constipation support improves stool consistency and promotes regular bowel movements for lasting digestive comfort.
Tributyrin Liquid Manufacturing Process
Cima Science produces its 99% pure Tributyrin Liquid in a cGMP-certified, ISO 9001 facility using food-grade raw materials and state-of-the-art purification technologies.
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Facility & Materials: Produced in a GMP-compliant, ISO 9001 facility using food-grade glycerol and butyric acid
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Esterification: Catalytic reaction of glycerol with butyric acid under precisely controlled temperature and pressure
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Neutralization: Removal of residual catalyst and free acid by gentle base treatment
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Vacuum Distillation: Multi-stage vacuum distillation to eliminate free fatty acids and volatile impurities
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Decolorization & Filtration: Treatment with activated carbon followed by fine filtration to achieve ≥ 99% purity by HPLC
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Quality Control: In-house testing for acid value, peroxide value, and microbial limits, and Third-party verification (e.g., SGS, Eurofins) for compliance with FDA GRAS, EU Novel Food and USP monograph standards
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Final Handling & Packaging: Nitrogen is blanketed in stainless steel storage tanks and filled into 25 kg or 200 kg HDPE drums for secure bulk delivery.
Where to buy bulk tributyrin liquid?
Cima Science Co., Ltd. is the best tributyrin liquid factory and a top China tributyrin factory for high-quality tributyrin liquid 99% at competitive wholesale prices. As the leading bulk tributyrin liquid manufacturer and best tributyrin powder factory in China, our GMP-certified manufacturing facility produces food-grade liquid and powder, with Kosher and Halal certificates. We offer OEM services, free samples, third-party testing reports (SGS/Eurofins), and flexible bulk packaging in 25 kg or 200 kg drums. For sale now: pure tributyrin liquid and powder from the most trusted China tributyrin factory. Contact our supplier team today for bulk, wholesale, custom capsules/softgels, and the best tributyrin liquid price.
