What is L-5-methyltetrahydrofolate Calcium?
L-5-methyltetrahydrofolate calcium powder (L-5-MTHF-Ca) is a biologically active form of folate, an essential B-vitamin (Vitamin B-9) your body needs for various functions.
This compound is also known by several other names such as:
- Calcium L-5-methyltetrahydrofolate
- L-methylfolate calcium
- Levomefolic acid
- (6S)-5-methyltetrahydrofolate
- (6S)-5-MTHF
Calcium L-5-methyltetrahydrofolate Vs Folic Acid
Chemical and Physical Features of Folic Acid
| Property | Folic Acid |
|---|---|
| IUPAC name | N-(4-{[(2-amino-4-oxo-1H-pteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid |
| Other names | Vitamin B9, Pteroylglutamic acid |
| CAS Number | 59-30-3 |
| Chemical formula | C19H19N7O6 |
| Molar mass | 441.4 g/mol |
| Appearance | Yellow-orange crystalline powder |
| Density | 1.59 g/cm3 |
| Melting point | 250 °C (decomposes) |
Why is L-5-MTHF Ca Better Than Folic Acid?
Calcium L-5-methyltetrahydrofolate (L-5-MTHF Ca) is a bioavailable alternative to folic acid in supplements, offering several advantages:
Better Bioavailability
This form of folate has better bioavailability than folic acid, meaning your body can absorb and utilize it more efficiently. This allows you to receive the full benefits of the supplement.
No Need for Metabolism
While the body must metabolize folic acid into the active form of folate, L-5-MTHF Ca can be absorbed directly without undergoing additional metabolic steps. This immediate bioavailability ensures a consistent supply of folate for your body’s needs.
Suitable for Various Populations
L-5-MTHF Ca is suitable for individuals with MTHFR gene mutations, making it an inclusive choice for many. Folic acid may not be well-tolerated or properly metabolized by those with certain genetic variations, so L-5-MTHF Ca is a more fitting option for these populations.
Ultra Pure with 99% Purity
Calcium L-5-methyltetrahydrofolate powder with 99% purity provides an exceptionally high-quality supplement option, ensuring you receive the best product for your nutritional needs.
In summary, L-5-MTHF Ca offers advantages over traditional folic acid, making it a preferred choice for many individuals. Its superior bioavailability, direct absorption, suitability for diverse populations, and ultra-pure formulation contribute to its increased effectiveness in meeting your body’s folate requirements.
L-5-Methyltetrahydrofolate Calcium Manufacturing Process
The synthesis process of L-5-MTHF-Ca involves the reduction of folic acid to tetrahydrofolic acid, followed by methylation and diastereoselective crystallization in water to form the calcium salt. To produce L-5-Methyltetrahydrofolate Calcium powder, you’ll need the following raw materials:
- folic acid
- Sodium borohydride
- Formaldehyde
- Calcium salt
The initial step involves the reduction of folic acid to tetrahydrofolic acid using sodium borohydride. This reaction ensures a stable structure for the vitamin, which is crucial to its absorption and function in your body. Next, formaldehyde is added to the tetrahydrofolic acid to form 5,10-MTHF, another essential intermediate compound.
Synthesis and Crystallization
After obtaining 5,10-MTHF, use sodium borohydride again to conduct a further reduction step. This reaction will yield the desired L-5-MTHF compound. At this point, the critical aspect of diastereoselective crystallization comes into play. When crystallizing L-5-MTHF in water, add a calcium salt, forming calcium L-5-MTHF – a white to light yellowish, almost odorless, water-soluble crystalline powder. This process ensures the final product’s correct ratio of L and D isomers.
Following GMP guidelines throughout the manufacturing process is essential to guarantee the highest quality and purity levels for your L-5-Methyletrahydrofolate Calcium powder. By adhering to these guidelines, you can ensure the potency and safety of your dietary supplement.
By following this manufacturing process, the resulting L-5-MTHF-Ca will contain not less than (NLT) 95.0% and not more than (NMT) 102.0% of calcium 5-methyltetrahydrofolate, as specified by the USP standards. This high 99% purity level ensures that the final powder is ideal for manufacturing dietary supplements, which is valuable for people seeking to enhance their folate intake and overall health.
Where to Buy Bulk L-5-MTHF Ca Powder?
If you’re searching for a reliable supplier of L-5-Methyletrahydrofolate calcium powder, look no further than Wuxi Cima Science. As a leading manufacturer in the industry, Cima Science specializes in producing high-quality nutritional supplements, including calcium salt forms of 5-methyltetrahydrofolate. They offer third-party lab guarantees and adhere to strict manufacturing standards to ensure product safety and effectiveness.
When you choose to purchase L-5-MTHF Ca Powder from Cima Science, you’re making a smart choice for several reasons:
- Quality and Safety: Their products undergo rigorous testing in third-party labs to guarantee purity, potency, and safety.
- Wholesale Pricing: By offering competitive wholesale prices, Cima Science makes it more accessible for businesses looking to incorporate L-5-MTHF Ca Powder into their product lines.
- GMP-Compliant Factory: Their state-of-the-art factory ensures production adheres to the highest quality standards and regulations.
- OEM Services and Private Label Available: Cima Science provides custom production, OEM, and private label solutions for companies looking to create their own unique products.
- Free Sample: Before placing a large order, you can request a free sample to test the quality and efficacy of their L-5-MTHF Ca Powder.
By choosing Cima Science as your supplier, you’ll have access to a trustworthy source of high-quality L-5-MTHF Ca Powder, ensuring your customers receive the best nutritional supplements available.
Are you ready to take the next step and order L-5-MTHF Ca Powder at wholesale pricing? Don’t hesitate to contact Cima Science today to get a quote and explore their customizable production solutions. Provide your customers with the essential vitamin B9 as 5-methyltetrahydrofolate calcium by partnering with a leading manufacturer like Wuxi Cima Science.
Get a wholesale price now by filling out the form or contacting us directly.
