What is SLU-PP-332?
SLU-PP-332, also known by its IUPAC name 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide or SLU PP-332, is a synthetic small-molecule pan-estrogen-related receptor (ERRα/β/γ) agonist that exhibits the highest potency at ERRα with an EC₅₀ of 98 nM. Unlike naturally occurring phytochemicals, it is chemically synthesized and not derived from any botanical source, featuring a hydrazone linkage between a 4-hydroxybenzamide moiety and a naphthalene ring system. Its molecular formula is C₁₈H₁₄N₂O₂, and its molecular weight is 290.32 g/mol. Registered under CAS number 303760-60-3 and listed in PubChem as CID 5404083, SLU-PP-332 is supplied as a white to off-white crystalline powder with a high-purity specification of ≥99.50% by HPLC. It demonstrates poor oral bioavailability (<1%), necessitating parenteral administration for research applications.
Packaged in 25 kg drums, Cima Science is the leading bulk SLU-PP-332 powder supplier in China and provides OEM services for formulation into capsules, tablets, and other dosage forms.
slu pp 332 Mechanism of Action
By directly binding and activating nuclear REV-ERBα and REV-ERBβ as well as estrogen-related receptors (ERRs), SLU-PP-332 shifts cellular metabolism toward enhanced energy efficiency and fat burning. As a potent, non-selective ERR agonist with the highest affinity for ERRα (EC₅₀ = 98 nM), it upregulates genes involved in mitochondrial biogenesis, fatty acid oxidation, and circadian rhythm regulation. Concurrent activation of REV-ERB receptors further optimizes lipid metabolism and promotes endurance by reinforcing the body’s natural clock and boosting mitochondrial function. In rodent models of metabolic syndrome, SLU-PP-332 treatment led to increased energy expenditure, reduced fat mass accumulation, and improved metabolic profiles, underscoring its promise for obesity and endurance-related research.
slu-pp-332 Benefits
SLU-PP-332 positively impacts metabolic health and physical performance regarding obesity, metabolic syndrome, and exercise physiology.
Enhanced Fat Oxidation and Energy Expenditure
SLU-PP-332 boosts mitochondrial activity to increase fatty acid oxidation, supporting greater energy utilization and fat loss. This makes it an ideal compound for obesity and metabolic disorder studies focusing on efficient energy regulation.
Circadian Rhythm Regulation
By agonizing REV-ERBα/β receptors, SLU-PP-332 helps synchronize the body’s internal clock, optimizing metabolic pathways, hormone release, and sleep-wake cycles. Researchers investigating circadian rhythm disorders and metabolic syndrome will find its clock-modulating effects especially valuable.
Improved Endurance
Preclinical models demonstrate that SLU-PP-332 enhances endurance and physical performance through mitochondrial biogenesis and improved muscle metabolism. This benefit positions it as a promising agent for studies on exercise capacity and energy balance.
Weight Loss & Metabolic Health
With its combined action on fat metabolism, energy expenditure, and circadian timing, SLU-PP-332 offers a multifaceted approach to weight management and metabolic homeostasis. Its potent receptor activation profile underscores its potential in developing novel anti-obesity interventions.
SLU-PP-332 Human Trials
To date, SLU-PP-332 has only been evaluated in preclinical models (rodent and in vitro studies), and no formal human clinical trials have been initiated. As a research-stage compound, its safety, pharmacokinetics, and efficacy in humans remain to be established. We will update this section with details of any upcoming or ongoing human trial studies as soon as they become available. If you are interested in participating in or sponsoring clinical research on SLU-PP-332, please contact Cima Science for the latest developments and collaboration opportunities.
Manufacturing Process of 99% SLU-PP-332 Powder
At Cima Science, our SLU-PP-332 powder undergoes a rigorously controlled multi-step synthesis and purification workflow to achieve ≥99% purity. Starting with high-grade raw intermediates, we perform an optimized condensation reaction under an inert atmosphere, followed by solvent extraction and multi-column chromatography to remove impurities. The crude product is then recrystallized in eco-friendly solvents and subjected to high-performance liquid chromatography (HPLC) monitoring at each stage to ensure consistent quality. After vacuum drying and micronization, the final white crystalline powder is confirmed at ≥99% purity by HPLC, nuclear magnetic resonance (NMR), and mass spectrometry (MS). Every batch is certified to meet international pharmacopoeial standards. It passes independent third-party quality testing for purity, residual solvents, and heavy metals, ensuring research-grade reliability for metabolic and endurance studies.
SLU-PP-332 Dosage
The recommended SLU-PP-332 dosage per day is 250 mcg, and researchers should follow the SLU-PP-332 dosage of 250mcg per day by taking one 250 mcg tablet orally with a glass of water and a light meal to enhance absorption and minimize gastrointestinal discomfort.
Where to buy bulk slu-pp-332 Powder
Cima Science Co., Ltd. is the leading SLU-PP-332 pure ingredient manufacturer and factory supplier in China. We offer SLU-PP-332 bulk powder for sale at competitive, high-quality prices. Our GMP-certified manufacturing facility produces wholesale and OEM SLU-PP-332 bulk powder with full third-party testing, Kosher and Halal certificates, and free sample options. Contact us to inquire about bulk orders, custom packaging, and certificates of analysis for SLU-PP-332 powder.
