What is Stearoylethanolamide?
Stearoylethanolamide (SEA) is a fully saturated C18 N-acylethanolamines. N-acylethanolamines (NAEs), collectively called anandamides, constitute a class of lipid compounds. NAEs are naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, N-acylphosphatidylethanolamine (NAPE).
PEA VS OEA VS SEA
| Product name | N-Stearoyl ethanolamide (SEA) | N-oleoyl ethanolamide （OEA） | N-Palmitoyl ethanolamide (PEA) |
| CAS number | 111-57-9 | 111-58-0 | 544-31-0 |
| Molecular formula | C20H41NO2 | C20H39NO2 | C18H37NO2 |
| Molecular weight | 327.55 | 325.55 | 299.5 |
| Appearance | Fine crystal | Fine Flake | Fine powder |
| Color | White to Off-white | White to Off white | White to Off white |
N-Palmitoylethanolamide product (PEA, C16:0 ethanolamine) is an endogenous fatty acid amide. It belongs to the class of nuclear transcription factor agonists.
N-Oleoylethanolamine (OEA, C18:1 ethanolamine) is a naturally occurring ethanolamide lipid. It is a natural analog of the endogenous cannabinoid anandamide.
N-Stearoylethanolamine (SEA C18:0 ethanolamine) is a fully saturated C18 N-acylethanolamine.
SEA Powder Manufacturing Process
The manufacturing process of Stearoylethanolamide (SEA) powder, achieving 99% purity, begins with the preparation of high-quality stearic acid and ethanolamine. These raw materials are essential for the esterification reaction that forms SEA.
During the esterification, stearic acid reacts with ethanolamine in the presence of a catalyst, typically in an alcohol solvent like ethanol or methanol. The reaction mixture is heated under controlled conditions to facilitate SEA formation.
The crude SEA is then purified through filtration to remove unreacted materials, by-products, and catalyst residues. The solvent is evaporated under reduced pressure, and the product undergoes crystallization by dissolving in a suitable solvent and cooling slowly. Recrystallization may be repeated to enhance purity.
Advanced techniques like High-Performance Liquid Chromatography (HPLC) achieve 99% purity, separating SEA from remaining impurities. The purified SEA crystals are dried under a vacuum to eliminate residual solvents and moisture.
Quality control tests, including melting point analysis, infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS), ensure the product meets the 99% purity requirement. Finally, the pure SEA powder is packaged in airtight containers to prevent contamination and degradation, ensuring a high-quality product.
Where to buy SEA in bulk?
Wuxi Cima Science Co., Ltd is a professional manufacturer of natural nutrients for more than 15 years with high quantities and a more comfortable price. We all have specialized production lines for N-Stearoyl ethanolamide (SEA), N-oleoyl ethanolamide (OEA), and N-Palmitoyl ethanolamide (PEA). You can also get technical knowledge from our professional team.
For American customers, you can get the bulk as soon as you need it, as we will keep the stock for you in our US warehouse.
Just feel free to contact me, if you want to know more information about the price, the certificate of analysis, MSDS, and so on.
