What is S-Adenosyl-L-Methionine?
S-Adenosyl-L-methionine is simply called SAMe or SAM-e in America, and also aliased as AdoMet or SAM. The names S-adenosyl methionine and S-adenosylmethionine also mean same substance S-Adenosyl-L-methionine. It is present naturally in the human body and plays an essential role in kinds of reactions in the body.
People found SAMe in the 1950s. Though nowadays Americans use S-Adenosyl-L-methionine for the dietary supplement, in the beginning, European countries including Italy, Spain, and Germany use it as a prescription drug.
SAMe donates methyl group in kinds of biosynthesis of proteins, neurotransmitters, nucleic and nucleic acids. This happens in many enzymatic transmethylation reactions.
SAMe has many health benefits, and people take it orally for depression, osteoarthritis, liver health and improving mood performance, etc. Many animal feeds also employ S-Adenosyl-L-methionine. Dogs often take the SAMe supplement for liver diseases.
Why manufacturers make S-adenosyl-L-methionine disulfate tosylate instead?
People have known the biological importance of S-Adenosyl-L-methionine for many years, but it has been only developed for drug and dietary supplement recently. Why? Because S-Adenosyl-L-methionine is extremely unstable for moisture and temperature. When the temperature above 0 °C or the SAMe discloses in a high humidity environment, the assay will degrade soon. Then the SAMe lost its biological activity because the S/S form((SS)-(+)-S-adenosyl-L-methionine) converted into R/S((RS)-(+)-S-adenosyl-L-methionine) form. It is a problem for the preparation of formulations.
So, what is the difference between S/S form and R/S form?
Ever before people thought both S/S form and R/S form of SAMe is biologically active, but facts prove it is not so. Studies disclose that S/S form is the active form for methyltransfering; on the contrary, R/S form inhibit this action.
Now that Pure SAMe is so unstable, how to solve this problem?
Through many experiments, researchers found that it can boost the stability to make SAMe into salt form. Finally, researchers choose two kinds of relatively stable forms: Adenosyl-L-methionine Disulfate Tosylate and Ademetionine 1, 4-butanedisulfonate. The former is mainly used for the dietary supplement, while the latter is primarily used for drug.
Researchers also proved that the trehalose could protect SAMe from degradation.
What other names does S-adenosyl-L-methionine disulfate tosylate have?
adenosyl-L-methionine disulfate p-toluenesulfonate
Adenosyl-L-methionine Disulfate Tosylate
S-adenosylmethionine tosylate disulfate
SAM tosylate disulfate
Ademetionine disulfate tosylate
What are the characters of S-adenosyl-L-methionine disulfate tosylate?
S-adenosyl-L-methionine disulfate tosylate is the disulfate form of the p-toluene-sulfonate complex of SAMe. It converts into active SAMe in cells to play its role. The structure of S-adenosyl-L-methionine disulfate tosylate is as below:
What are the functions of s adenosyl l methionine?
Osteoarthritis and Joint Health
In several studies, the participants take 400-1200mg daily. Finally, the results indicate that SAMe can alleviate the pain of persons who suffer from Osteoarthritis. Comparing with pharmaceutical solutions for osteoarthritis such as NSAIDs, Celecoxib, Naproxen, Nabumetone,etc., SAMe shows similar potency, though it may take a longer time. Then how long? Most patients can feel the obvious effect after 1-2 months administration.
Several studies proved that SAMe could improve depression symptoms effectively, even better than prescription antidepressants. If you do not have an excellent response to the drug, SAMe should be helpful for you.
Some participants with osteoarthritis said that after taking SAMe their depression symptoms relieved much.
What is the mechanism for depression? Studies show that SAMe plays this role through promoting the metabolism of dopamine and serotonin neurotransmitters in the brain.
SAMe showed good effect for kinds of liver diseases such as fatty liver, Cirrhosis, and Virus hepatitis, as well as other liver function disorder. SAMe can adjust glutathione levels in red blood cells, we know, the glutathione is very important for liver health. The glutathione levels become abnormal in the damaged liver.
One study noted that after taking 1200mg SAMe daily for two years, the liver damage rate down to 12% from 29%.
How does s adenosyl l methionine play its role?
SAMe plays an essential role in the regulatory pathway of Vitamin B12 and folic acid. Folate first transforms into active form 5-methyltetrahydrofolate, which converts cyclic homocysteine to L-methionine. Then the L-Methionine combines with Adenosine group to generate S-Adenosylmethionine(SAMe). Then the SAMe donates methyl groups for a series of bodily reactions. After that, SAMe becomes S-Adenosylhomocysteine and continues participating in the cycle as mentioned above.
The flow chart of S-adenosyl methionine cycle as below:
What brands of S adenosylmethionine are popular on the market?
SAMe is one popular product. It is easy for you to find many brands both online and offline. On Amazon, search the SAMe, you can find many famous brands including Jarrow, Doctor’s Best, and LifeExtension. When you go to the supermarket such as Costco, as well as the GNC store, you also can find similar SAMe supplement easily.
What is the dosage of s adenosyl l methionine?
For osteoarthritis, daily dosage 600-1200mg SAMe by mouth; For depression, orally take 800-1600mg of SAMe per day; For liver disease, suggest daily oral dosage 500-1600mg.
How about the safety of s adenosyl l methionine(SAMe)?
SAMe is generally safe. The data of long-term safety is limited because most people only take SAMe for a short time. Anyway, in one study, the participants took s adenosyl l methionine for two years, no apparent side effects were founded.
For people with Parkinson’s disease, it may weaken the effects of L-dopa.
Side effects of the SAme are rare, even if they occur, they are little problems such as digestive upsets.
Where to buy s adenosyl l methionine?
CIMA Science always supplies high-quality S-adenosyl-L-methionine disulfate tosylate to the market; the bulk stock is available in both Chinese and Los Angeles warehouse.