N-Acetyl Cysteine Powder (NAC)

Product name	N-Acetyl Cysteine Bulk Powder
Other names	N-Acetyl L-Cysteine, N-Acetyl-L-Cysteine, N-Acetylcysteine, NALC, NAC Cysteine
CAS number	616-91-1
Molecular Formula	C5H9NO3S
Molecular Weight	163.19
Production Capacity	3500 metric tons per year
Specifications	99% Pure HPLC
Appearance/color	White Crystalline Powder
Benefits	Immune Response, Respiratory Health, Liver Health
Bulk Packaging	25kg/drum
OEM Services	Custom package, private labels, formulation development, contract manufacturing, micronized powders, capsules, tablets

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Description

What is N-Acetyl Cysteine?

N-Acetyl Cysteine powder (NAC), also known as N-Acetyl-L-Cysteine or Acetylcysteine (CAS Number: 616-91-1), is a semi-essential amino acid derivative and powerful antioxidant with the molecular formula C₅H₉NO₃S and a molecular weight of 163.19 g/mol. NAC is synthesized rather than botanically sourced, typically appearing as a white crystalline powder with a characteristic sulfur odor.

Wuxi Cima Science Co., Ltd., the leading bulk NAC powder supplier in China, offers pharmaceutical-grade NAC with 99% minimum purity verified by HPLC, featuring exceptional bioavailability in its free-form structure for maximum absorption and efficacy in the human body. Cima‘s premium NAC powder is available in various package sizes, including 1kg foil bags, 25kg drums, and custom packaging options to meet diverse client needs, and beyond supplying the raw ingredient, Wuxi Cima Science also provides comprehensive OEM services for finished NAC finished products including capsules, tablets, powders, and other dosage forms for global health supplement brands.

NAC Forms & Specifications

N-Acetyl-L-Cysteine (NAC) in its free form exists in a pure, unbound state rather than being attached to or combined with other compounds like salts or esters. This unmodified structure represents NAC in its most natural and potent state, making it highly desirable for health applications and supplement formulations.

Premium quality NAC produced by Cima Science maintains a minimum purity level of 99% as verified through HPLC (High-Performance Liquid Chromatography) testing. This exceptional purity standard ensures maximum effectiveness when used in health supplements.

N-Acetyl-Cysteine vs Glutathione

While both NAC and glutathione powder play crucial roles in antioxidant defense and detoxification, NAC generally offers superior practical benefits for most consumers. NAC serves as a precursor to glutathione in the body, effectively raising glutathione levels while being more stable, affordable, and bioavailable through oral supplementation. Glutathione, though powerful when it reaches cells, struggles with poor oral absorption unless in liposomal form. NAC demonstrates stronger clinical evidence for liver support, while glutathione may have slight advantages for skin whitening effects. Many health practitioners recommend taking NAC with vitamin C for optimized glutathione production rather than direct glutathione supplementation. The combined approach of NAC, glutathione, and vitamin C offers synergistic benefits for comprehensive antioxidant support, but NAC alone often provides the best value for enhancing glutathione status. Detailed Comparison of NAC vs Glutathione is as below:

Feature	N-Acetyl-Cysteine (NAC)	Glutathione
CAS Number	616-91-1	70-18-8
Other Names	Acetylcysteine, N-Acetyl-L-Cysteine	GSH, L-Glutathione, Reduced Glutathione
Molecular Formula	C₅H₉NO₃S	C₁₀H₁₇N₃O₆S
Molecular Weight	163.19 g/mol	307.32 g/mol
Appearance	White crystalline powder	White to off-white powder
Food Sources	Not directly found in foods (cysteine found in chicken, turkey, yogurt, eggs)	Avocados, asparagus, spinach, okra, fresh fruits
Specifications	99% by HPLC (Wuxi Cima Science standard)	98-99% by HPLC for pharmaceutical grade
Oral Bioavailability	Moderate to good (can cross cell membranes)	Poor (easily degraded in GI tract) unless liposomal
Potency	Moderate directly; high as glutathione precursor	High when it reaches cells
Half-life	5.6-6.25 hours	2-3 hours in plasma
Stability	Highly stable in supplement form	Unstable, easily oxidized, degrades quickly
Popularity	Very high; widely used in clinical settings	Growing, especially in liposomal and cosmetic applications
Pricing	$30-60/kg bulk; $15-30 for consumer supplements	$200-500/kg bulk; $30-80 for consumer supplements
Liver Benefits	Strong direct evidence for liver protection	Beneficial but less direct evidence than NAC
Skin Whitening	Moderate effects	More pronounced effects than NAC
Respiratory Support	Excellent (used medically as mucolytic)	Moderate effects
Detoxification	Excellent, clinically used for acetaminophen overdose	Excellent but limited by bioavailability
Prescription Status	Previously OTC in US, now more regulated	Generally available as supplement
Manufacturing	Synthesized (Wuxi Cima Science is a leading supplier)	Synthesized or yeast-derived

Synergistic Applications:

NAC + Glutathione: NAC enhances glutathione production while providing direct benefits
NAC + Vitamin C: Vitamin C regenerates oxidized glutathione and enhances NAC efficacy
Liposomal Glutathione vs NAC: Liposomal delivery improves glutathione absorption but at significantly higher cost than NAC
Liver Support Protocol: NAC is often preferred over glutathione for direct liver protection
Skin Brightening: Combination of NAC, glutathione and vitamin C provides optimal results for skin tone improvement

Wuxi Cima Science offers premium NAC powder at 99% purity for manufacturers seeking to develop effective glutathione-boosting supplements, combination formulas, and OEM finished products.

N-Acetyl-L-Cysteine Manufacturing Process

Wuxi Cima Science employs a sophisticated, pharmaceutical-grade manufacturing process for N-Acetyl-L-Cysteine (NAC) production, adhering to strict GMP and ISO standards. The process begins with premium-quality L-cysteine that undergoes a controlled acetylation reaction under precise temperature and pH conditions. This is followed by multiple purification stages, including crystallization, filtration, and advanced chromatography techniques to eliminate impurities. Each batch undergoes rigorous quality control testing, including HPLC analysis to verify a minimum of 99% purity, heavy metal screening, and microbial testing. The final product is carefully dried using specialized low-temperature methods that preserve the molecular integrity of NAC while yielding a consistent white crystalline powder. Cima Science’s manufacturing facility features state-of-the-art equipment with automated monitoring systems throughout production, ensuring exceptional batch-to-batch consistency and full traceability from raw materials to finished products.

NAC Benefits

N-Acetyl Cysteine (NAC) is a remarkable supplement that functions as a direct antioxidant and a precursor to glutathione, the body’s master antioxidant. With decades of clinical research supporting its use, NAC offers diverse benefits ranging from respiratory health to cognitive function. Here are the key evidence-based benefits of this versatile compound:

Lung Health & Immune Support – NAC provides powerful nutritional support as an antioxidant, supporting lung functioning through its mucolytic capability
Respiratory Support Supplement – NAC N-Acetyl Cysteine supports lungs and their functioning through its mucolytic and antioxidant action
Powerful Antioxidant Protection – N-Acetyl Cysteine (NAC) is a precursor to the antioxidant glutathione; supplemental NAC supports tissue levels of glutathione
Liver Support & Detoxification – The supplement N Acetyl Cysteine supports liver health and detoxification; typically free from gluten, wheat, and common allergens
Immune System Enhancement – May reduce frequency and severity of certain viral infections
Brain Health Protection – Shows promise for conditions involving neuroinflammation and oxidative stress
Fertility Support – May improve sperm quality, motility, and overall reproductive health
Mood Regulation – Emerging research suggests benefits for certain mood and psychiatric disorders
Kidney Protection – Helps prevent damage from contrast dyes used in medical imaging
Skin Health Improvement – Supports clearer skin through antioxidant and anti-inflammatory properties
Heavy Metal Detoxification – Assists in binding and removing certain heavy metals from the body

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Where to buy N-Acetyl Cysteine Bulk Powder?

Wuxi Cima Science Co., Ltd. is China’s premier NAC factory, providing pharmaceutical-grade N-Acetyl Cysteine powder to global supplement brands, pharmaceutical companies, and distributors. Our state-of-the-art manufacturing facility operates under strict GMP certification, ensuring every batch of NAC meets 99% purity standards verified by HPLC testing.