NMNH powder, or reduced nicotinamide mononucleotide, is a highly potent and bioavailable supplement known for boosting NAD+ (nicotinamide adenine dinucleotide) levels within the body. NAD+ is a critical molecule in cellular energy production and overall cellular health. By increasing NAD+ levels, your body may experience improved energy, cognitive function, and overall well-being.

As the reduced form of NMN, NMNH is naturally found in the kidneys and has been shown to be a more efficient NAD+ enhancer than its precursor, NMN powder. With a molecular formula of C11H17N2O8P and a CAS number of 108347-85-9, this white crystalline powder is sold as a highly pure and stabilized supplement, ensuring optimal results for your health endeavors.

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What is NMNH Powder?

NMNH (Reduced Nicotinamide Mononucleotide) is a dietary supplement that aims to improve your NAD+ levels with anti-aging and longevity benefits. The powdered form is widely used for its efficacy and convenience in consumption.

Definition of NMNH

NMNH is the reduced form of Nicotinamide Mononucleotide (NMN), a critical intermediate in the biosynthesis of NAD+. NMNH promotes NAD+ production and has multiple health benefits. When you take NMNH as a supplement, it enhances NAD+ production and suppresses glycolysis, the TCA cycle, and cell growth.

As a supplement, NMNH powder is ideal due to its high bioavailability and rapid absorption into your bloodstream, making it highly efficient in increasing NAD+ levels in your body.

Chemical and Physical Features of NMNH Molecule

The molecular formula of NMNH is C11H17N2O8P. It is also known as ‘1-(5-O-phosphono-beta-D-ribofuranosyl)-1,4-dihydropyridine-3-carboxamide Reduced Nicotinamide Nucleotide’. Structurally, it differs from NMN as it is a fluorescent molecule.

NMNH has been demonstrated to be a more potent NAD+ enhancer than NMN, both in vitro and in vivo, mediated by nicotinamide mononucleotide adenylyltransferase (NMNAT). Furthermore, NMNH elevates the reduced NAD (NADH) levels in cells and in mouse livers. Metabolomic analysis indicates that NMNH inhibits glycolysis and the TCA cycle.

Due to its high purity and stability, manufacturers are able to produce NMNH powder through environmentally friendly whole-enzymatic methods that leave no harmful solvent residues behind.

Sources of Reduced Nicotinamide Mononucleotide

Natural Sources of NMNH

While reduced nicotinamide mononucleotide (NMNH) is a potent NAD+ enhancer, finding natural sources of this compound can be challenging. To date, there have not been any reported natural sources of NMNH. However, it is important to understand that NMNH is derived from nicotinamide mononucleotide (NMN), naturally found in various food items. Some natural sources of NMN include:

  • Edamame
  • Broccoli
  • Cabbage
  • Avocado
  • Tomatoes

It is worth noting that, although these foods contain NMN, consuming them will not directly increase NMNH levels in your body.

Synthetic Sources of NMNH

Since natural sources of NMNH are scarce, researchers have developed chemical synthesis methods to produce this powerful NAD+ enhancer. A typical production process involves the reduction of NMN to produce NMNH. This reduction results in a new and potent NAD+ precursor that is more effective than NMN and nicotinamide riboside (NR) in increasing cellular NAD+ levels.

The development of NMNH synthesis methods allows for its use in various applications, such as dietary supplements and therapeutic treatments. As a result, you can now find NMNH in the form of powder or capsules. These supplements can be a viable option to enhance NAD+ levels and support cellular health, longevity, and overall well-being.

When selecting an NMNH supplement, choosing a reputable brand that adheres to strict manufacturing and quality control standards is vital. This ensures that you are getting a safe, high-quality product with the potential to deliver the desired benefits.

NMNH vs. NMN, which is better?

This section will discuss the differences between NMNH and NMN, two NAD+ precursors gaining attention in the supplement market. We’ll compare them in popularity, potency, stability, pricing, and legal status.

Both are NAD+ Precursors

NMNH and NMN are both precursors of NAD+, a coenzyme that plays a critical role in cellular metabolism and aging processes. While both compounds help boost NAD+ levels in the body, they have different properties and degrees of effectiveness.


NMN has been popular and widely studied for its NAD+ boosting properties. NMNH is relatively new to the supplement market but has shown promising results, potentially surpassing NMN in some areas.


Studies have found that NMNH can significantly increase NAD+ levels in the body, even more than NMN. In fact, NMNH has been reported to raise NAD+ levels up to 10 times at lower concentrations, while NMN could only double the levels.


NMNH has demonstrated more excellent stability compared to NMN. Injected NMNH was found to be stable for up to 24 hours, while NMN was stable for only the first 4 hours. This superior stability may contribute to NMNH’s higher potency.


NMNH tends to be more expensive than NMN due to its higher potency and newer status in the market. As the manufacturing process for NMNH improves, the price difference may change in the future.

Legal status as a supplement

While NMN has gained popularity, it is currently banned by the FDA. NMNH, on the other hand, has not faced such restrictions and can be legally marketed as a supplement.

As more research emerges, the choice between NMNH and NMN may become more evident. For now, weigh the factors discussed here to decide which NAD+ precursor is best for you and consult a healthcare professional if necessary.

NMNH Powder Manufacturing Process

Raw Materials Used

NMNH powder production begins with essential raw materials, such as NADH, Escherichia Coli (EcNADD) enzymes, and Tris HCL. These components play a vital role in converting NADH into NMNH and AMP.

Simple Steps

The manufacturing process of NMNH powder follows a few basic yet efficient steps. These involve:

  • Filtration: Selective separation of the components based on size or other properties.
  • Purification Process: In this stage, NMNH is separated from AMP using the High-Performance Liquid Chromatography (HPLC) method, specifically by C18 reverse-phase chromatography.
  • Evaporation: After the separation, pure NMNH fractions are evaporated until they are dry to obtain the final product.

Quality Control

Ensuring the purity and consistency of NMNH powder is crucial. Manufacturers implement various quality control measures, such as:

  • Testing for Purity: The purity of NMNH powder is thoroughly examined, ensuring it meets the desired standards.
  • Ensuring Consistency: Manufacturers strive to maintain consistent quality throughout the production process, ensuring each batch of NMNH powder has the intended purity and stability.

Health Benefits of NMNH Supplements

As you explore NMNH supplements, it’s essential to understand the various health benefits they offer. This section will focus on two primary benefits: anti-aging and longevity.


NMNH (Reduced Nicotinamide Mononucleotide) has gained attention for its potential anti-aging properties. By effectively boosting NAD+ levels in your body, NMNH supplements can help combat age-related cellular degeneration. This can lead to improved skin health and reduced visible signs of aging.

Additionally, increased NAD+ levels can support better brain health, reducing the risk of cognitive decline and other age-related neurological disorders. By incorporating NMNH supplements into your routine, you may experience a more youthful appearance and better cognitive function as you age.


A remarkable benefit of NMNH supplements is their potential impact on longevity. By providing your body with a more potent and efficiently absorbed NAD+-boosting component, NMNH may promote healthy aging and support a longer lifespan. The increased NAD+ levels contribute to better cellular function, improving overall health and vitality.

Improving NAD+ levels is also associated with protective effects on the heart, reducing the risk of age-related cardiovascular issues. Incorporating NMNH supplements into your daily routine could support a longer, healthier life, allowing you to enjoy more time with friends and family.

Where to Buy NMNH Powder in Bulk?

CIMA Science is a reputable natural ingredient manufacturer based in China, specializing in producing and supplying high-quality raw materials, including NMNH Powder. As a professional supplier, OEM, and factory, they are dedicated to providing exceptional customer service and ensuring their products meet rigorous industry standards.

Advantages of Buying NMNH Powder from Cima Science

There are several key benefits to consider when purchasing NMNH Powder in bulk from Cima Science:

  • High purity: Up to 99% purity, ensuring you receive a quality product that meets your needs.
  • Wholesale price: Cima Science offers competitive pricing ideal for bulk purchases of NMNH Powder.
  • Third-party lab testing: All products undergo rigorous testing by accredited third-party labs, guaranteeing their purity, identity, and potency.
  • Ready inventory: Cima Science maintains a well-stocked NMNH Powder inventory available in 1kg/bag and 25kg/drum packaging options.

Your search for a reliable and high-quality NMNH Powder supplier ends here. Contact CIMA Science now to get a quote and experience the benefits of partnering with a trustworthy and experienced natural ingredient manufacturer. Don’t miss this opportunity to source the finest NMNH Powder for your business needs.

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