What is wogonin?

Wogonin, also called 5,7-dihydroxy-8-methoxyflavone, is one bioactive flavonoid originated from Scutellaria baicalensis. It is one of the major bioactive flavonoids, playing an important role in the physiological activity of Scutellaria baicalensis. Except for wogonin, Baicalin and Baicalein are the other two common kinds of bioactive flavones in Baical skullcap root. The structures of those three flavones as below:

wogonin chemical structure

Baicalin chemical structure

Baicalein chemical structure

There are about 350-400 species of Scutellaria that could be found in the world. Among them, Chinese Scutellaria baicalensis is the most common one, which has been used as a traditional medicine to cure various diseases with over 2000 years’ history.

The content of wogonin, baicalin, and baicalein in the root of S.baicalensis is much different. Among them, the wogonin content is the lowest.

Details as tablet 1:

Contens of baicalin, baicalein and wogonin in water extracts of each gram Scutellariae Radix

The major bioactive flavone wogonin exhibits a wide range of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, anti-hepatitis, neuroprotective, anti-angiogenesis, anti-allergic, anxiolytic and anticonvulsant, etc. Especially wogonin exhibits wide spectrum promising antitumor effects in animals and the human body. Those activities are realized through kinds of molecular mechanisms such as NF-KB, tumor necrosis factor-alpha, Ca2+, reactive oxygen species, etc

What are the characters of wogonin?

Product Name Wogonin
Synonyms Vogonin; Norwogonin 8-methyl ether; 5,7-Dihydroxy-8-methoxyflavone;

5,7-Dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one

CAS Number 632-85-9
Molecular Formula C16H12O5
Structure wogonin chemical structure
Molecular Weight 284.267g/mol
Specification 98%
Melting Point 203~206℃
Appearance/Color Fine yellow powder
Benefits Anti-inflammatory,Antioxidant,Anticancer, etc
Applications For dietary supplement and medicines
Recommend Dosage Vary according to different symptoms
Package Packed in paper drums and two plastic bags inside.25kg/drum.
Storage Condition Stored in a well-closed container away from moisture and direct sunlight.

What are the benefits of wogonin?

(1)Anti-inflammatory

Wogonin exhibits a variety of anti-inflammatory properties through different mechanisms, including inhibition of prostaglandin E2 production, nitric oxide as well as cyclooxygenase-2 expression induced by TPA.

Wogonin not only can regulate the expression of inflammation-associated genes but also inhibit the activity of enzymes associated with inflammation. Those enzymes include lipoxygenases, cyclooxygenases, etc. What is more, wogonin also regulates the expression of inflammation-associated proteins.

Wogonin can work in conjunction with similar flavones such as chrysin and apigenin.
As the most common form of arthritis, Osteoarthritis(OA) would lead to the destruction of articular cartilage. Wogonin plays a promising role in Osteoarthritis management. It can relieve OA-associated molecular events such as inflammation, matrix degradation, and oxidative stress in tissues.

Anti-inflammatory properties of wogonin via several signaling pathways

(2) Antioxidant

Studies report that wogonin can inhibit transendothelial cell migration of MDA-MB-231, which is one kind of human breast cancer cells, as well as H2O2-stimulated action remodeling. Also, wogonin can suppress H2O2-induced vascular permeability. Through regulate the expression of serine-threonine kinase, the wogonin supplement could obviously cut down hydroperoxide-induced apoptosis.

Wogonin shows neuroprotective actions and also suppresses several kinds of neuronal damage induced by oxidative stress. Its antioxidant effects should contribute to the neuroprotective function.

One study found that all wogonin, baicalein, and oroxylin A exhibited free-radical scavenging as well as obvious antioxidative activities. Especially among them, wogonin showed the most significant effect.

What is more, wogonin also can reduce liver damage because of antioxidant and SOD activity.
The neuroprotective effect of wogonin is mainly featured by its antioxidant and anti-inflammatory activity.

(3)Anticancer

Wogonin shows anticancer activity for many kinds of cancers. When wogonin is used together with other anticancer drugs such as etoposide and 5-fluorouracil, it can not only reverse drug resistance but also enhance chemotherapy, which has been proved.

Anticancer activity of wogonin against various cancers

What is the dosage of wogonin?

According to scientific research, in vitro, under dosage 1.25, 2.5, 5, 10, 20ug/ml, wogonin can inhibit ethanol-induced inflammatory response. In vivo, wogonin(25,50,100mg/kg) can fight against liver injury. In a xenograft model wogonin(30,60mg/kg) inhibit tumor growth of cells HCT116.

How about the safety of wogonin? Does wogonin have side effects?

On the one hand, in vitro wogonin can induce apoptosis in many human tumor cells, and on the other hand, in vivo for different mouse tumor models, wogonin can suppress tumor growth. Most important, under dosage lethal to tumor cells, wogonin showed no obvious toxicity for animals, and for normal cells exhibited no or little toxicity.

How to enhance the bioavailability of wogonin?

Though wogonin exhibits a variety of pharmacological activities, its poor solubility and low bioavailability limit its application in clinical administration. If so, how to enhance its bioavailability and therapeutic activity? New drug delivery systems, including salification technology, liposomes as well as magnetic nanoparticles(MNPs) have been developed out.

Where to buy the wogonin?

More and more studies focus on wogonin, but because of the tiny amount in Scutellaria baicalensis, the cost of wogonin is high. There are few manufacturers commercially producing wogonin.

Through 10 years’ research and development, Wuxi Cima science co.,ltd has finally gotten a great breakthrough on the production technology. We make it become possible to produce cost affordable wogonin commercially.

What specification of wogonin do you have?

We can offer a wide spectrum of wogonin specifications, 1%-98%. Typical specifications include 1%, 5%, 10%, 15%, 98% wogonin.

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