What is Uncaria rhynchophylla?
Uncaria rhynchophylla (or Gouteng in Chinese), UNCARIAE RAMULUS CUM UNCIS), is an essential Chinese herbal material with a long history. Uncaria rhynchophylla ethanol-extracted powder, which preserves the Chinese herb’s properties, is also widely used in dietary supplements.
- Its harvest in autumn and winter, remove leaves, cut and dry.
- Parts used: dried stems and branches with hooks.
Uncaria rhynchophylla chemical constituents include:
- Alkaloids: rhynchophylline, isorhynchophylline, corynoxeine,isocorynoxeine, corynoxine,corynoxine B, etc.
- Flavonoids: hypericin, etc.
- Others: mitragynin, isomitragynin, etc.
Research shows that the total alkaloid content of different parts of Uncaria rhynchophylla varies. For example, the underground skin is 0.65%, the epidermis is 0.30%, the hook is 0.28%, the young branches and leaves are 0.18%, and the xylem is 0.022% to 0.04%.
Uncaria rhynchophylla VS Uncaria tomentosa (Cat’s Claw)
Uncaria rhynchophylla and Uncaria tomentosa are both common species of the family of Rubiaceae, and what’s the difference between them?
|Product name||Uncaria rhynchophylla||Uncaria tomentosa|
|Synonym||Gou Teng||Cat’s Claw,uña de gato|
|Origin place||China Guangxi, Jiangxi, Hunan, Zhejiang, Guangdong, Sichuan, Yunnan, etc.||South and Central America, Peru, etc|
|Common species||Uncaria rhynchophylla,Uncaria macrophylla,Uncaria sinensis,
|Uncaria. tomentosa and Uncaria. guianensis|
|Part used||Dried stem, branch & hooks||Vine bark, root|
|Standardized Extract||1%-10%Uncaria total alkaloids||3% alkaloids and 15% phenols|
|Main actions||Hypertension, neuroprotective, anticonvulsive, Immune Booster,etc||stimulates the immune system, reduces inflammation, fights free radicals, cleanses bowel, etc|
Uncaria rhynchophylla Clinical Applications
The following are the early clinical applications of Uncaria rhynchophylla raw material as Chinese herbal medicine.
For fever convulsions
Uncaria rhynchophylla is commonly used in children and adults with high fever convulsions. In addition, it is beneficial for children’s acute infantile convulsions. Uncaria rhynchophylla also relieve spasm for a mild tiqueur. Because single-use is not very significant, it is often used with antelope horns or gastrodia elata. The whole scorpion strengthens the effect of clearing away heat and relieving spasms.
For liver-wind dizziness
Uncaria rhynchophylla has the sedative effect on lowering blood pressure and dizziness caused by high blood pressure . Uncaria rhynchophylla also helps improve the numbness of the limbs. It’s often combined with mulberry leaves, chrysanthemum, Panax Tseng flowers, white Peony, etc.
According to recent studies, Uncaria rhynchophylla decocted in water with Ephedra and Schisandra appears to be particularly beneficial in treating chronic bronchitis of phlegm and asthma.
Uncaria rhynchophylla Extract total alkaloids
It was reported that the active pharmacological component was the alkaloids of Uncaria rhynchophyllina, reprententive are rhynchophylline and isorhynchophylline.
Rhyncholphylline, its cas# is 76-66-4. Studies have shown that it directly and reflexively inhibits the vascular motor center and blocks sympathetic nerves and ganglia, dilates peripheral blood vessels, reduces vascular resistance and blood pressure, and has antiplatelet aggregation and antithrombotic effects.
The CAS number of Isorhynchophylline is 6859-01-4. The ingredient is unstable, and its main effects are on blood pressure, heart rate, vasomotor, platelet aggregation, thrombosis, Ca2+ channels, vascular smooth muscle cell proliferation, and apoptosis. It can also protect cerebral ischemia, protect nerve cells, and be anti-inflammatory.
Uncaria rhynchophylla Extract Benefits
Hypertension directly threatens the quality of life and is the leading cause of cardiovascular and cerebrovascular events.
Uncaria rhynchophylla is a well-known traditional herb against hypertension. Research reported that hirsutine, an integrant of Uncaria Rhynchophylla, has cardioprotection on hypoxic neonatal rat cardiomyocytes. Its chemical components, rhynchophylline and isorhynchophylline, can dilate peripheral vessels by directly inhibiting the vasomotor center and blocking the sympathetic nerves or ganglions.
For Brain Health(Central Nervous System)
Researchers found that the Uncaria rhynchophylla chemical constituents could ameliorate cognitive deficits in the STZ-induced AD rats. The underlying molecular mechanism involves suppressing tau hyperphosphorylation, anti-oxidant, and anti-neuroinflammation via modulating Akt (Ser473)/GSK3β(Ser9)-mediated Nrf2 activation.
These findings imply that Uncaria rhynchophylla extract is worthy of being developed clinically into a pharmaceutical treatment for Alzheimer’s disease.
- Immune Booster
There is a patent showing the compound isolated from the Extract of Uncaria rhynchophylla is HIV-1 protein degradation. It offers a potent inhibitory effect on the enzyme’s activity; it can be used as a pharmaceutical composition and functional health food to prevent acquired immune deficiency syndrome.
Uncaria rhynchophylla Extract Supplements
Uncaria rhynchophylla + Gastrodia formula
Gastrodia(Tian Ma) and Uncaria rhynchophylla (Gou Teng) formula is a famous compatibility plan that reduces dizziness and improves sleep.
Uncaria rhynchophylla +White Peony Extract formula
White Peony, also known as Paeonia lactiflora or Bai Shao, is good at inhibiting inflammatory factors from supporting immune health.
Uncaria rhynchophylla combinates with white Peony can help maintain your immune system’s balanced cellular activity to stay healthy and responsive.
Uncaria rhynchophylla + Panax Tseng + Eucommia formula
It will be an excellent formula for Uncaria for its blood pressure-lowering effect. In addition, the Panax Tseng flower can reduce the proportion of cholesterol in the blood and reduce the blood’s viscosity. Eucommia Extract is also a popular raw material for health. Its active ingredient has a mild anti-hypertensive effect and specifically impacts hypertensive patients.
Uncaria rhynchophylla Extract safety and side effects
Uncaria rhynchophylla is low in toxicity.
Oral administration of Uncaria total alkaloids to mice (LDS is 514.6±29, 1 mg/kg) and Uncaria total alkaloids to juvenile rats (50 mg and 100 mg/kg daily) showed no apparent toxicity.
Please be cautious when using single Traditional Chinese Medicine, herbs, or herbal extracts. Natural herbs from China are mostly combined together with other herbs in the formulas to enhance each other’s desirable action and minimize any potential side effects.
Uncaria rhynchophylla Extract dosage
There is currently no evidence in humans to recommend an ideal human dose. Still, our recommended dosage is 100-200mg/daily for Uncaria rhynchophylla Extract 1% Uncaria total alkaloids based on some studies.
Where to buy Uncaria rhynchophylla Extract
Cima Science Team has researched Uncaria rhynchophylla since 2018 from raw materials to manufacturing to applications, providing bulk Uncaria rhynchophylla Extract powder, from 1%-10% Uncaria total alkaloids different specifications, confirmed offer high quality and provide related technical supports.
If you are interested in Uncaria rhynchophylla Extract or want to use it in your new formula, please feel free to contact the Cima sales team. We will provide feedback on your quality documents and quotation within 24 hours.
- Jiang P, Chen L, Xu J, Liu W, Feng F, Qu W. Neuroprotective Effects of Rhynchophylline Against Aβ1-42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation. Neurochem Res. 2021 Sep;46(9):2439-50. https://pubmed.ncbi.nlm.nih.gov/34170454/
- Zhu K, Yang SN, Ma FF, Gu XF, Zhu YC, Zhu YZ. The novel analogue of hirsutine as an anti-hypertension and vasodilatory agent both in vitro and in vivo. PLoS One. 2015;10(4):e0119477. https://pubmed.ncbi.nlm.nih.gov/25909998/
- Yang W, Ip SP, Liu L, Xian YF, Lin ZX. Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions. Curr Vasc Pharmacol. 2020;18(4):346-57. https://pubmed.ncbi.nlm.nih.gov/31272356/
- Zeng P, Su HF, Ye CY, Qiu SW, Tian Q. Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes. Front Pharmacol. 2021;12:806984. https://pubmed.ncbi.nlm.nih.gov/34975502/
- A composition comprising the compound isolated from Uncaria rhynchophylla suppressing of HIV-1 protease activity for preventing and treating acquired immune deficiency syndromehttps://patents.google.com/patent/KR20110047326A/en