What is Tripterygii Radix?
Celastrol Powder is one of the key active ingredients found in Tripterygii Radix, the dried root and rhizome of the Thunder God Vine. The Tripterygium genus includes four known species: Tripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, and Tripterygium forrestii Dicls. Among these species, Tripterygium wilfordii Hook.f and its subspecies Tripterygium hypoglaucum Hutch are the most widely used in China because they contain high levels of biologically active compounds such as diterpenoids, triterpenoids, and alkaloids.
Thunder God Vine, also known as Lei Gong Teng, grows mainly in the southern regions of China. It is commonly distributed in Zhejiang, Fujian, Anhui, Jiangxi, Hunan, and Taiwan, where the natural environment favors the accumulation of important plant metabolites including Celastrol.
Cima Science supplies high-purity Celastrol Powder 98 percent extracted from Tripterygium wilfordii using advanced purification technologies. All products are manufactured in GMP-certified facilities and verified through strict quality control processes. We offer bulk and wholesale quantities to support global research institutions, nutraceutical developers, and formulation scientists.
Whether your needs involve laboratory research, natural product development, or R and D formulation projects, Cima Science provides consistent quality, competitive pricing, and dependable worldwide delivery.
Active ingredients in Radix Tripterygium wilfordii Hook F
Radix Tripterygium wilfordii Hook F (Thunder God Vine) contains a diverse profile of bioactive compounds. These naturally occurring constituents are primarily grouped into diterpenoids, triterpenoids, and alkaloids, each contributing to the plant’s unique biological activity. Below is an overview of the major ingredient classes and their key representatives.
1. Diterpenoids
Diterpenoids are among the most extensively studied bioactive compounds in Tripterygium wilfordii. They are recognized for their potent and wide-ranging biological effects, making them a primary focus in natural product research. The most notable diterpenoids include Triptolide (CAS No. 38748-32-2), a highly investigated compound known for its strong cellular activity, and Tripdiolide (CAS No. 38647-10-8), another key constituent with similar structural characteristics. In addition to these major compounds, Tripterygium wilfordii contains several other diterpenoid lactones in smaller quantities, each contributing to the overall pharmacological potential of the plant.
2. Triterpenoids
Triterpenoids form another major chemical group in Tripterygium wilfordii, playing a significant role in the plant’s research value due to their structural diversity and demonstrated biological activity. Among these, Celastrol (CAS No. 34157-83-0) is the most prominent, widely studied for its unique triterpenoid quinone methide structure and potent bioactivity. Wilforlide A (CAS No. 84104-71-2) is another important triterpenoid commonly found in the plant, supporting its recognized activity profile. Beyond these major compounds, Tripterygium wilfordii also contains a variety of additional triterpenoid esters and acidic derivatives that further broaden its natural chemical landscape.
3. Alkaloids
Alkaloids from Tripterygium wilfordii form a structurally rich category of nitrogen-containing compounds that are valued for their complexity and research potential. Notable representatives include Wilforgine (CAS No. 37239-47-7), a well-characterized alkaloid frequently referenced in phytochemical studies, and Wolverine (CAS No. 11088-09-8), another significant component with distinct structural features. The plant also contains Wilforidine and several other minor alkaloid constituents, all of which contribute to the diverse and intricate chemical profile of Tripterygium wilfordii and support ongoing interest in its natural product chemistry.
What is Celastrol?
Celastrol (Cel) is a highly active pentacyclic triterpene isolated from Lei Gong Teng and exhibits a variety of pharmacological activities.
Celastrol Powder 98% Specifications
| Item | Specification |
|---|---|
| Product Name | Celastrol Powder |
| Purity | ≥98% (HPLC) |
| CAS Number | 34157-83-0 |
| Source | Tripterygium wilfordii (Natural Plant Extract) |
| Molecular Formula | C₂₉H₃₈O₄ |
| Molecular Weight | 450.60 g/mol |
| Appearance | Red to reddish-orange powder |
| Identification | HPLC / NMR |
| Loss on Drying | ≤2.0% |
| Ash | ≤1.0% |
| Heavy Metals | ≤10 ppm |
| Residual Solvents | Meets USP requirements |
| Microbial Limits | <1000 cfu/g |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry place away from light |
Bioavailability of Celastrol
The solubility of celastrol in water is low (13.25 0.83 mg/ml at 37℃). When Qi et al. (193) investigated the solubility of celastrol in several vehicles, they found that ethyl oleate, olive oil, the surfactants Labrasol and OP-10, and the cosurfactants PEG200, ethanol, butanol, and notably Transcutol P were suitable solvents with a solubility >20 mg/ml.
Celastrol-loaded lipid nanospheres, liposomal celastrol, and solid self-micro emulsifying dispersible celastrol tablets can significantly increase their oral bioavailability, effectiveness, and side effects.
Key Features & Benefits
- 98% HPLC purity with full chromatographic fingerprint
- Extracted from natural Tripterygium wilfordii
- Manufactured in GMP-certified facilities
- Batch COA available for every shipment
- Consistent particle size and stability
- Low residual solvents and heavy metals
- Available in bulk and wholesale quantities
- Vacuum-sealed packaging ensures long-term stability
- Global export experience and fast delivery
Applications of Celastrol 98%
Celastrol powder from Cima Science is widely used across scientific and industrial research areas:
1. Biomedical Research
Used for studies involving:
- Antioxidant mechanisms
- Inflammation pathways
- Cellular stress response
- Metabolic and obesity-related pathways
- Heat shock protein induction
2. Plant & Natural Product Research
- Botanical extract standardization
- Natural triterpenoid evaluation
3. Pharmaceutical R&D
- Preclinical research
- Natural compound screening
- New active compound discovery
4. Laboratory Experiments
- In vitro studies
- In vivo investigations
- Mechanistic biological pathway research
Packaging & Supply Options
Cima Science provides flexible packaging solutions to meet the diverse requirements of global B2B customers. For small to medium-sized research and formulation needs, Celastrol Powder is available in secure 1 kg aluminum foil bags that protect the material from moisture, light, and oxidation. For organizations requiring slightly larger quantities, we offer 5 kg double-layer bags designed to maintain product stability during storage and transportation.
For bulk-scale purchases, our standard commercial packaging consists of a 25 kg fiber drum, which is lined with protective inner bags to ensure long-term product safety and integrity. This format is ideal for manufacturers, laboratories with high consumption volumes, and companies involved in large-scale production or R and D. Custom packaging options are also available upon request to support specialized supply chain or branding needs.
Every shipment from Cima Science includes a complete documentation package that ensures full transparency and quality assurance. Customers receive a Certificate of Analysis (COA), an HPLC chromatogram, and an MSDS with each order. A third-party laboratory test report can also be provided when required. These documents confirm purity, identity, and safety, allowing clients to confidently integrate Celastrol Powder into their research or product development workflows.
Celastrol Powder Manufacturing Process
The manufacturing process for Celastrol Powder begins with the careful selection of Tripterygium wilfordii roots, which serve as the primary natural source of this triterpenoid compound. High-quality raw materials are collected from controlled regions where the plant is traditionally grown, and each batch undergoes strict identity verification to ensure authenticity and potency. After initial cleaning and drying, the plant material is finely milled to increase extraction efficiency.
Once prepared, the milled Tripterygium wilfordii undergoes solvent extraction to separate the bioactive constituents from the plant matrix. The extract is then filtered and concentrated to enrich the triterpenoid fraction. Through a series of controlled purification steps, including column chromatography and solvent refinement, Celastrol is isolated from other natural components. This stage is essential to achieve the high purity required for research and formulation applications.
The purified Celastrol solution is then subjected to crystallization and drying to produce a stable and high-purity powder. Advanced drying techniques help maintain the integrity, color, and chemical structure of the compound. Following drying, the material is refined through sieving and homogenization to ensure consistent particle size and optimal handling characteristics.
Each batch of Celastrol Powder undergoes rigorous quality testing, including HPLC assay, NMR identification, heavy metal screening, microbial analysis, and residual solvent evaluation. Only materials that meet strict GMP and international quality standards are approved for packaging. The final product is securely filled into aluminum foil bags or fiber drums, depending on order size, and shipped with complete documentation including COA, HPLC chromatogram, MSDS, and optional third-party test results.
This controlled, multi-stage process ensures that Cima Science delivers Celastrol Powder with reliable purity, stability, and batch-to-batch consistency for global research and development needs.
Where to buy pure Celastrol powder
Celastrol is very expensive in the market. Cima Science has the advantage of providing pure 98%powder in bulk.
For research institutions, nutraceutical developers, and formulation specialists seeking high-purity Celastrol Powder, Cima Science is one of the most reliable and established suppliers in China. We specialize in producing Celastrol Powder 98 percent extracted from Tripterygium wilfordii using advanced purification technology. Every batch is manufactured in GMP-certified facilities and verified through comprehensive quality testing to ensure consistent purity, potency, and safety.
Cima Science provides bulk and wholesale Celastrol Powder with flexible order quantities and competitive factory pricing. Whether you require small pilot quantities for early-stage research or large commercial volumes for ongoing production, we support a wide range of B2B sourcing needs. Free samples, COA, HPLC chromatograms, MSDS, and third-party test reports are available upon request to help customers conduct internal evaluations with confidence.
As a direct manufacturer rather than a trading company, Cima Science offers fast lead times, stable supply, and full documentation for international shipment. Our technical team can also provide assistance with custom specifications, OEM services, and formulation support for large-scale projects.
For reliable quality, consistent purity, and professional service, Cima Science is the preferred choice for purchasing pure Celastrol Powder. Contact our sales team today to request bulk pricing, samples, or additional product information.
