What’s Luteolin?
Luteolin powder is considered to be one of the most abundant flavonoids in science. (Luteolin flavonoid), which contains more than 4,000 different flavonoids. A yellow crystalline pigment commonly found in many plants as a luteolin glucoside.
Luteolin is a natural flavonoid with potential antioxidant, anti-inflammatory, apoptotic and chemopreventive activities. Flavonoids are polyphenols and an indispensable part of the human diet. Flavonoids are phenyl substituted chromones (benzopyran derivatives), which are composed of 15-carbon basic skeleton (C6-C3-C6). Here is Luteolin structure:
Why more vegetables and fruits?
Plant ingredients such as flavonoids have been shown to have health benefits. There are many flavonoids in nature, and luteolin is one of them.
Luteolin Sources
Later, researchers discovered the flavonoid, luteolin, from these plants. Through these foods as natural chemical preventive agents, people have proposed that flavonoids are many positive effects on human health. So, what foods does luteolin come from?
Green leaves such as parsley and celery rank first among rich luteolin foods. Dandelions, onions, and olive leaves are also good luteolin food sources. For other sources of luteolin, please refer to the luteolin food list below.
In addition to some of the sources listed above, we also tested the luteolin content of some materials used in daily life, including some spices.
However, what is the supplement market’s commercial source of luteolin raw materials? At first, Luteolin was extracted from peanut shells, a by-product of peanut processing. Then, considering the cost and efficiency, people gradually began using rutin as a luteolin extraction source. Rutin is also the source of Cima luteolin powder.
Luteolin powder benefits
Because of its antioxidant and anti-inflammatory properties, luteolin has many uses as a health product. Luteolin is often formulated with palmitoylethanolamide PEA. When combined, palmitoylethanolamide and luteolin show synergistic effects for their anti-inflammatory, antioxidant, and neuroprotective properties.
These properties enable luteolin to scavenge active compounds containing oxygen and nitrogen, which can cause cell damage. Other biological effects of luteolin include the activation of dopamine transporters.
Memory support
Aging is one of the causes of many neurodegenerative health problems. Therefore, much attention has been focused on developing neuroprotective agents derived from natural sources. Among these phytochemicals, dietary flavonoids are an essential and universal chemical bioactive product, especially luteolin. It is found that luteolin can slow down cognitive decline and improve memory, significantly affecting Alzheimer’s. Luteolin brain health issues deserve attention.
Nervous system
Learning and memory are the main functions of the central nervous system, which are essential for adaptation and survival. The hippocampal structure is the key brain area involved in learning and memory. Cognitive deficits in Down syndrome seem to be caused by abnormal neurogenesis. Luteolin was fed to mice with abnormal hippocampal structure. The results showed that the number of neurons in the brain of mice increased. Luteolin improved learning and memory ability improved new object recognition ability and Improved the proliferation of hippocampal dentate gyrus neurons.
Antioxidant support
Luteolin has excellent antioxidant properties. By comparing the free radical scavenging activities of quercetin, rutin, luteolin, and apigenin, it was found that luteolin and quercetin provided effective antioxidant protection against attack. Apigenin has no protective effect. Rutin is just the edge. Luteolin has twice the antioxidant capacity of vitamin E.
Healthy inflammation management
Luteolin inflammation effect is proved: Researchers have found that using flavonoids can accelerate the production of new cells in inflammation. Anti-inflammatory activities include activating antioxidant enzymes, inhibiting the NF-kappaB pathway, and inhibiting pro-inflammatory substances. We discovered that Luteolin had the best impact by comparing three commonly used flavonoids (Salicin, Apigenin, and Luteolin).
Luteolin Safety
Luteolin, as a natural source of flavonoids, has been used in supplements for many years. Taking it in a reasonable dose has proved to be safe and effective.
Luteolin dosage
Because luteolin is almost insoluble in water, they are often sold in luteolin capsules. There is no strict regulation on the dosage of luteolin in any institution, but the recommended dosage for scientific research institutes and production is 100mg-200mg/day.
Besides, we also mentioned that children and pregnant women should use luteolin cautiously unless, under the guidance of a professional doctor, the specific dose needs to be determined by the doctor according to the actual situation.
Luteolin supplement applications
We can find luteolin supplements on many shopping websites, such as Amazon. There are luteolin capsules and tablets. Here are some examples of luteolin and other ingredients used together.
Luteolin and Palmitoylethanolamide
Social communication disorders and repetitive, restrictive behavior define autism spectrum disorder (ASD). The mixture of fatty acid amide palmitoylethanolamide (PEA) and luteolin showed neuroprotective and anti-inflammatory effects in different pathological models of the central nervous system. It has a positive impact on ASD symptoms.
(For a detailed introduction to PEA, please search ’Palmitoylethanolamide’ on our company website or link https://cimasci.com/products/palmitoylethanolamide/)
Luteolin and Rutin
As we mentioned above, one of the sources of luteolin is derived from rutin. So is the combination of luteolin rutin supplements reasonable? The answer is logical. Because rutin also has antioxidant and anti-inflammatory effects, but its mechanism of action is different from luteolin, such a combination is to achieve the overall effect of antioxidant and anti-inflammatory.
Luteolin and Quercetin
Quercetin and luteolin are different raw materials. Quercetin and luteolin food sources also are different. Why do quercetin and luteolin supplements exist as a formula? Because quercetin has a positive effect on cardiovascular ailments, such as hypertension. As mentioned in our discussion above, luteolin is having a similar impact. So the purpose of Formula luteolin quercetin is the centralized formula for cardiovascular ailments.
Luteolin Price
Cima Science has not set a minimum order quantity for Luteolin, and we can meet any early new project stage and supply chain replacement demand for mass production. The price of Luteolin bulk powder depends on different amounts and modes of transportation. We have a flexible pricing list and choose the best transportation mode and cost in combination with its use time. If you are interested in Luteolin from Cima Science, don’t hesitate to contact our sales and you will get a quotation as soon as possible.
Where to buy Luteolin powder in bulk?
With the in-depth study of Luteolin, its positive effect on the human body has also been affirmed. Especially in today’s dietary supplement market, we will find that more and more products begin to add Luteolin and use other raw materials to achieve the best results. As the largest luteolin supplier in China, CIMA also hopes that more and more people will improve their health through Luteolin.
CIMA is committed to optimizing the production of Luteolin, making more breakthroughs in quality, and meeting the requirements of governments for supplement raw materials (purity, heavy metals, microorganisms, solvent residues, pesticide residues, no additives, etc.). Please get in touch with us if you are interested in it or need our help. We will reply within 1-2day and try our best to solve your most urgent problems.
References:
- Lin, Y., Shi, R., Wang, X., & Shen, H.-M. (2008). Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy. Current Cancer Drug Targets (Vol. 8, Issue 7, pp. 634–646). Bentham Science Publishers Ltd. https://doi.org/10.2174/156800908786241050
- Luo, Y., Shang, P., & Li, D. (2017). Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms. In Frontiers in Pharmacology (Vol. 8). Frontiers Media SA. https://doi.org/10.3389/fphar.2017.00692
- Wang, Z., Zeng, M., Wang, Z., Qin, F., Chen, J., & He, Z. (2021). Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism. In Journal of Agricultural and Food Chemistry (Vol. 69, Issue 5, pp. 1441–1454). American Chemical Society (ACS). https://doi.org/10.1021/acs.jafc.0c08085
- Gendrisch, F., Esser, P. R., Schempp, C. M., & Wölfle, U. (2020). Luteolin as a modulator of skin aging and inflammation. In BioFactors (Vol. 47, Issue 2, pp. 170–180). Wiley. https://doi.org/10.1002/biof.1699
- De Stefano, A., Caporali, S., Di Daniele, N., Rovella, V., Cardillo, C., Schinzari, F., Minieri, M., Pieri, M., Candi, E., Bernardini, S., Tesauro, M., & Terrinoni, A. (2021). Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside. In International Journal of Molecular Sciences (Vol. 22, Issue 3, p. 1321). MDPI AG. https://doi.org/10.3390/ijms22031321
