Luteolin is considered to be one of the most abundant flavonoids in science. (Luteolin flavonoid), which contains more than 4,000 different flavonoids. A yellow crystalline pigment commonly found in many plants as a luteolin glucoside.
Luteolin is a natural flavonoid with potential antioxidant, anti-inflammatory, apoptotic and chemopreventive activities. Flavonoids are polyphenols and an indispensable part of the human diet. Flavonoids are phenyl substituted chromones (benzopyran derivatives), which are composed of 15-carbon basic skeleton (C6-C3-C6). Here is Luteolin structure:
Why more vegetables and fruits?
Cardiovascular disease (CVD) has become a significant cause of morbidity and mortality worldwide. A well-monitored diet and adequate fruit and vegetable intake have been identified as primary preventive measures against CVD, which is why nutritionists call for more vegetables and fruits. Plant ingredients such as flavonoids have been shown to have health benefits. There are many flavonoids in nature, and luteolin is one of them.
When it comes to the origin of luteolin, we have to start with the Asian diet. Asians have a much lower risk of colon cancer, prostate cancer, and breast cancer. They consume more vegetables, fruits, and tea than people in the Western Hemisphere. Meanwhile, several plants and spices containing flavonoid derivatives have been used as disease prevention and treatment agents in traditional Asian medicine for thousands of years.
Later, researchers discovered the flavonoid, luteolin, from these plants. Through these foods as natural chemical preventive agents and anticancer agents, people have proposed that flavonoids are many positive effects on human health. So, what foods does luteolin come from?
Green leaves such as parsley and celery rank first among rich luteolin foods. Dandelions, onions and olive leaves are also good luteolin food sources. For other sources of luteolin, please refer to the luteolin food list below.
In addition to some of the sources listed above, we also tested the luteolin content of some materials used in daily life, including some spices.
However, in the drug or supplement market, what is the commercial source of luteolin raw materials? At first, luteolin was extracted from peanut shell, a by-product of peanut processing. Then, considering the cost and efficiency, people gradually began to use rutin as a source of luteolin extraction. Rutin is also the source of Cima luteolin powder.
Because of its antioxidant and anti-inflammatory properties, luteolin has many uses as health products. Luteolin is often formulated with palmitoylethanolamide PEA. When combined, palmitoylethanolamide and luteolin show synergistic effects for their anti-inflammatory, anti-oxidant, and neuroprotective properties.
These properties enable luteolin to scavenge active compounds containing oxygen and nitrogen, which can cause cell damage. Other biological effects of luteolin include activation of dopamine transporters.
Aging is one of the causes of many neurodegenerative diseases. Therefore, much attention has been focused on the design and development of neuroprotective agents derived from natural sources. Among these phytochemicals, dietary flavonoids are an essential and universal chemical bioactive product, especially luteolin. It is found that luteolin can slow down cognitive decline and improve memory, which has a significant effect on Alzheimer’s disease. Luteolin brain healthy issues deserve attention.
Learning and memory are the main functions of the central nervous system, which are essential for adaptation and survival. The hippocampal structure is the key brain area involved in learning and memory. Cognitive deficits in Down syndrome seem to be caused by abnormal neurogenesis. Luteolin was fed to mice with abnormal hippocampal structure. The results showed that the number of neurons in the brain of mice increased. Luteolin improved learning and memory ability improved new object recognition ability and To improve the proliferation of hippocampal dentate gyrus neurons.
Luteolin has excellent antioxidant properties. By comparing the free radical scavenging activities of quercetin, rutin, luteolin, and apigenin, it was found that luteolin and quercetin provided effective antioxidant protection against attack. Apigenin has no protective effect. Rutin is just the edge. Luteolin has twice the antioxidant capacity of vitamin E.
Healthy inflammation management
Luteolin exhibits specific anti-inflammatory effects at micromolar concentrations, partly because of its antioxidant capacity. Anti-inflammatory activities include activation of antioxidant enzymes, inhibition of NF-kappaB pathway and inhibition of pro-inflammatory substances.
Luteolin inflammation effect is proved: Researchers have found that the use of flavonoids can accelerate the production of new cells in inflammation. By comparing three commonly used flavonoids (Salicin, Apigenin, and luteolin), we found that luteolin had the best effect.
Luteolin and Cancer: Many papers have described the inhibitory effects of luteolin on tumors and cancer. Proteasomes regulate cell apoptosis, which is a natural form of abnormal cell death. Proteasome activity increases in cancer cells. Proteasome can inhibit cell growth and induce abnormal cell apoptosis. That’s the so-called defense against cancer.
Luteolin at low micromolar range inhibits the proliferation of normal cells and tumor cells as well as angiogenesis in vitro. Inhibition of extensive neovascularization can help prevent some chronic diseases, including solid malignant tumors. Luteolin exhibits strong anti-proliferative activity in different human cancer cell lines (e.g., in hormone-dependent cancer lines, such as breast cancer, prostate cancer, and thyroid cancer).
In addition, recent studies have shown that luteolin has a positive effect on hair growth, cataract and other symptoms. It can prevent gout, protect the liver and reduce blood sugar. Even some scholars have suggested that luteolin can accelerate the healing of skin wounds.
Luteolin side effects
In animal and cell studies, luteolin does not damage healthy cells or cause significant side effects. We also mentioned that luteolin could improve the symptoms of cancer, especially breast cancer. But for uterine and cervical cancer, as well as the impact of estrogen in women, more research and data are needed to prove whether it is harmful.
Although luteolin can prevent spontaneous colitis (colitis) in animals and consume excessive doses of luteolin, it can exacerbate chemical-induced colitis. Children and pregnant women should avoid luteolin as much as possible.
Because luteolin is almost insoluble in water, they are often sold in luteolin capsule. At present, there is no strict regulation on the dosage of luteolin in any institution, but the recommended dosage for scientific research institutes and production is 100mg-200mg/day.
Besides, we also mentioned that children and pregnant women should use luteolin cautiously unless, under the guidance of a professional doctor, the specific dose needs to be determined by the doctor according to the actual situation.
Luteolin supplement applications
We can find luteolin supplements on many shopping websites, such as Amazon. There are luteolin capsules and tablets. Here are some examples of luteolin and other ingredients used together.
Luteolin and Palmitoylethanolamide
Autism spectrum disorder (ASD) is a disease defined by social communication disorders and repetitive, restrictive behavior. The mixture of fatty acid amide palmitoylethanolamide (PEA) and luteolin showed neuroprotective and anti-inflammatory effects in different pathological models of the central nervous system. It has a positive impact on the treatment of ASD symptoms.
(For a detailed introduction to PEA, please search ’Palmitoylethanolamide’ on our company website or link https://cimasci.com/products/palmitoylethanolamide/)
Luteolin and Rutin
As we mentioned above, one of the sources of luteolin is derived from rutin. So is the combination of luteolin rutin supplements reasonable? The answer is logical. Because rutin also has antioxidant and anti-inflammatory effects, but its mechanism of action is different from luteolin, such a combination is to achieve the overall effect of antioxidant and anti-inflammatory.
Luteolin and Quercetin
Quercetin and luteolin are different raw material. Quercetin and luteolin foods sources also are different. Why quercetin and luteolin supplement exist as a formula? Because quercetin has a positive effect on cardiovascular diseases, such as hypertension. As mentioned in our discussion above, luteolin is having a similar impact. So the purpose of Formula luteolin quercetin is the centralized formula for cardiovascular diseases.
Do I need luteolin supplement?
If you feel that some neurological abnormalities are beginning to occur, especially if you are over 50 years old, you may need additional luteolin supplements. These functions include memory, learning and motor skills. Inflammation and oxidative stress affect symptoms of the nervous system, such as skin damage and wrinkles, which are some of the most significant signs that you may need luteolin. Autoimmune disorders may also mean that you need extra luteolin. When we decide we need luteolin supplements, please note luteolin supplements buy from a regular drugstore or shopping website. About luteolin price also check with the seller.
With the in-depth study of luteolin, its positive effect on the human body has also been affirmed. Especially in today’s dietary supplements market, we will find that more and more products began to add luteolin, with other raw materials to achieve the best results.
As the largest luteolin supplier in China, Cima also hopes that more and more people will improve their health through luteolin. If you need our help or discussion, please feel free to contact us. We will try our best to solve your problems. At the same time, it is also welcomed.