What is Polydatin?
Polydatin, another name is Piceid, is a glucoside of resveratrol in which glucose transferred to the C-3 hydroxyl group.
Polydatin has two isomeric forms that exist in nature, cis-polydatin, and trans-polydatin.
It is a well-known stilbene compound, also a terpenoid, with healthy biological activity. Previous studies proved it has potential as an active material, mainly focus on cardiovascular supports, anti-oxidation, anti-tumor, liver protection, etc.
Usually, 98% of natural polydatin derived from an Asian origin herb Polygonum Cuspidatum Sieb. Et Zucc, appeared white-powder, as one of the main active ingredients.
4 Foods that Are Good Sources of Polydatin
Polydatin widely distributed in plants, the most abundant source is Polygonum Cuspitadum. Also, you can found it in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products, and many daily diets.
Polydatin first reported in the peel of grapes. And grape skins exhibit higher polydatin contents than the seeds (Kammerer et al. 2004).
In red grape juices, trans-polydatin’s average concentrations is 3.38 mg/L,cis-polydatin is 0.79 mg/L;In white grape juices, trans-polydatin is 0.18 mg/L,cis-polydatin is 0.26 mg/L.
contents in natural peanut butter were found to be significantly higher than those in
blended peanut butter.
Red wine contains up to 14.3 mg/l, and 29.2 mg/l of trans-resveratrol and polydatin.
Cocoa and chocolate
Polydatin detected in cocoa and chocolate products is about 3-5 times more than Resveratrol.
|cocoa powders||7.14 LG/g|
|unsweetened baking chocolates||4.04 LG/g|
|semisweet chocolate baking Chips||2.01 LG/g|
|dark chocolates||1.80 LG/g|
|milk chocolates||0.44 LG/g|
|chocolate syrups||0.35 LG/g|
Polydatin is Resveratrol?
Obviously, the answer is NO.
Resveratrol, also known as 3,4′,5-Trihydroxy-Trans-stilbene, a stilbenoid, a type of natural phenol, and it is famous for chemopreventive, antidiabetic, and neuroprotective properties.
Polydatin is a biological precursor of resveratrol, resveratrol’s glucoside form. The related brand is PTEROMAX™ by Biotivoia.
Compared to resveratrol, polydatin has many advantages:
- Anti-oxidant – increased resistance to enzymatic oxidation
- Transport – it penetrates the cell via an active carrier mechanism using glucose carriers
- A high degree of solubility in water – due to its water solubility, polydatin is absorbed in the intestine, the bioavailability is 4-5 times greater than resveratrol.
|Botanical source||Polygonum Cuspidatum Sieb. et Zucc(Polygonaceae)
|Molecular weight||228.24g·mol−1||390.388 g·mol−1|
4 Important Biological Activity of Polydatin
Effect on the cardiovascular system
Jin Chunhua and other studies on rat cardiomyocytes by PD showed that it has a superior cardiac function and significantly improved myocardial efficiency. It also has effects on vascular smooth muscle cells (VSMC), anti-platelet aggregation, and vascular endothelial damage thrombus.
Protection against tissue and organ damage caused by various factors
Experimental study of the effects of PD on crush injury and multiple organ failure (MOF) in rats, which showed that it can prevent or reduce the increase of protein creatinine and bronchoalveolar lavage fluid protein content and hematocrit, and can be different. To a certain extent, improve the body’s antioxidant capacity.
PD has a phenolic hydroxyl structure, similar to the ongoing construction of the free radical scavenger vitamin E. Its inhibition of free radical production may be the primary mechanism to prevent tissue and organ damage.
PD protects the liver and inhibits the accumulation of lipid-like peroxides in the liver. It shows that it can effectively preserve damaged liver cells from 1×10-7to 1×10– 4mmol·L -1 The cell survival rate was significantly improved, and the survival rate of hepatocytes was 88.7 % with 1×10-5 mmol·L-1, close to normal cultured liver cell levels.
Lowering blood lipids and anti-lipid peroxidation
Zhang Peiwen et al. also found that sublingual resveratrol sputum 212mg.kg.d – 1, for 3 consecutive days, can increase the ratio of serum cholesterol, low-density lipoprotein/high-density lipoprotein (LDL / HDL) and Hematocrit returns to normal, and has a tendency to reduce high shear rate and low shear rate of whole blood.
In-depth study of it, it is possible to develop a new class of drugs to treat cardiovascular disease and improve microcirculation, liver protection, and blood lipid lowering.
2 Typical Combinations of Polydatin
Antioxidation-Pterostilbene, Polydatin, and Resveratrol combination
The stilbene is a plant material of the fitoDlexine family that interacts with biological structures by activating repair processes and defense mechanisms.
Pterostilbene, polydatin, and resveratrol affect cell growth and stress resistance. These stilbenes induce the expression of MnSOD in mammalian cells.
The combination of three materials will achieve stronger antioxidant and powerful action against free radicals.
Anti-inflammatory Palmitoylethanolamide and Polydatin combination
As we know, Palmitoylethanolamide (PEA), an endogenous fatty acid amide, has anti-inflammatory and neuroprotective effects. Polydatin has antioxidant activity.
Also, many studies show that the two combinations can be reduced to vascular damage and attenuates the inflammatory process. One research has suggested that micronized palmitoylethanolamide(PEA) 400mg, polydatin 40mg twice a day, have good effectiveness in chronic pelvic pain.
Also, polydatin can be combined with grape seed extract(OPC), piperine, quercetin, Nicotinamide Mononucleotide(NMN), etc. in dietary supplements.
Polydatin is Safe?
As a dietary supplement,polydatin do not apply with GRAS currently, but it was viewed as safe by many clinical trials; for injection grade, there is a company called Shenzhen Neptunus Bioengineering, has submitted to the USFDA application. And it is also could as an ingredient used in cosmetic products according to European Union law.
Because it has not pointed out the correct dosage of polydatin, we can find out through market application, such as BioForte, PTEROMAX™(by Biotivia), polydatin dosage range from 5mg~100mg, combined with Resveratrol and Pterostilbene.
Polydatin is a rising material in the dietary supplement market, and no adverse effects report yet.
Where You Buy Polydatin Powder?
Due to the limitation of raw materials, there are no more than three real manufacturers of polydatin in China, but WUXI CIMA SCIENCE has excellent advantages in supplying it, each batch has 200-300 kg produced with 98%fine white powder by HPLC, top quality, none excipient, has a great control in heavy metals, microorganisms, solvent residues and so on.
Technical documents specification sheet, certificate of analysis, MSDS, and quotation are glad to share you.