What is Polydatin?
Polydatin powder, also known as Piceid, is a glucoside of resveratrol powder in which glucose is transferred to the C-3 hydroxyl group.
Polydatin has two isomeric forms that exist in nature, cis-polydatin, and trans-polydatin.
It is a well-known stilbene compound with healthy biological activity and a terpenoid compound. Previous studies proved it has potential as an active material, mainly focusing on cardiovascular support, anti-oxidation, anti-tumor, liver protection, etc.
Usually, 98% of natural polydatin is derived from an Asian origin herb Polygonum Cuspidatum Sieb. Et Zucc appeared with white powder as one of the main active ingredients.
Food Sources of Polydatin
Polydatin is widely distributed in plants, the most abundant source is Polygonum Cuspitadum. Also, you can find it in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products, and many daily diets.
Polydatin was first reported in the peel of grapes. And grape skins exhibit higher polydatin contents than the seeds (Kammerer et al. 2004).
In red grape juices, trans-polydatin’s average concentrations is 3.38 mg/L,cis-polydatin is 0.79 mg/L;In white grape juices, trans-polydatin is 0.18 mg/L,cis-polydatin is 0.26 mg/L.
contents in natural peanut butter were found to be significantly higher than those in
blended peanut butter.
Red wine contains up to 14.3 mg/l, and 29.2 mg/l of trans-resveratrol and polydatin.
Cocoa and chocolate
Polydatin detected in cocoa and chocolate products is about 3-5 times more than Resveratrol.
|cocoa powders||7.14 LG/g|
|unsweetened baking chocolates||4.04 LG/g|
|semisweet chocolate baking Chips||2.01 LG/g|
|dark chocolates||1.80 LG/g|
|milk chocolates||0.44 LG/g|
|chocolate syrups||0.35 LG/g|
Polydatin is Resveratrol?
The answer is NO.
Resveratrol, also known as 3,4′,5-Trihydroxy-Trans-stilbene, is a stilbenoid, a type of natural phenol famous for chemopreventive, antidiabetic, and neuroprotective properties.
Polydatin is a biological precursor of resveratrol, resveratrol’s glucoside form. The related brand is PTEROMAX™ by Biotivoia.
Compared to resveratrol, polydatin has many advantages:
- Anti-oxidant – increased resistance to enzymatic oxidation
- Transport – it penetrates the cell via an active carrier mechanism using glucose carriers
- A high degree of solubility in water – due to its water solubility, polydatin is absorbed in the intestine, and the bioavailability is 4-5 times greater than resveratrol.
|Botanical source||Polygonum Cuspidatum Sieb. et Zucc(Polygonaceae)
|Molecular weight||228.24g·mol−1||390.388 g·mol−1|
4 Important Biological Activity of Polydatin
Effect on the cardiovascular system
Jin Chunhua and other studies on rat cardiomyocytes by PD showed superior cardiac function and significantly improved myocardial efficiency. It also affects vascular smooth muscle cells (VSMC), anti-platelet aggregation, and vascular endothelial damage thrombus.
Protection against tissue and organ damage caused by various factors
An experimental study of the effects of PD on crush injury and multiple organ failure (MOF) in rats showed that it could prevent or reduce the increase of protein creatinine and bronchoalveolar lavage fluid protein content and hematocrit and can be different. To a certain extent, it improves the body’s antioxidant capacity.
PD has a phenolic hydroxyl structure, similar to the ongoing construction of the free radical scavenger vitamin E. Its inhibition of free radical production may be the primary mechanism for preventing tissue and organ damage.
PD protects the liver and inhibits the accumulation of lipid-like peroxides in the liver. It shows that it can effectively preserve damaged liver cells from 1×10-7to 1×10– 4mmol·L -1 The cell survival rate was significantly improved, and the survival rate of hepatocytes was 88.7 % with 1×10-5 mmol·L-1, close to normal cultured liver cell levels.
Lowering blood lipids and anti-lipid peroxidation
Zhang Peiwen et al. also found that sublingual resveratrol sputum 212mg.kg.d – 1, for 3 consecutive days, can increase the ratio of serum cholesterol, low-density lipoprotein/high-density lipoprotein (LDL / HDL), and Hematocrit returns to normal, and has a tendency to reduce the high shear rate and a low shear rate of whole blood.
In-depth study of it, it is possible to develop a new class of drugs to treat cardiovascular disease and improve microcirculation, liver protection, and blood lipid lowering.
2 Typical Combinations of Polydatin
Antioxidation-Pterostilbene, Polydatin, and Resveratrol combination
The stilbene is a plant material of the fitoDlexine family that interacts with biological structures by activating repair processes and defense mechanisms.
Pterostilbene, polydatin, and resveratrol affect cell growth and stress resistance. These stilbenes induce the expression of MnSOD in mammalian cells.
Combining three materials will achieve stronger antioxidants and powerful action against free radicals.
Anti-inflammatory Palmitoylethanolamide and Polydatin combination
As we know, Palmitoylethanolamide powder (PEA), an endogenous fatty acid amide, has anti-inflammatory and neuroprotective effects. Polydatin has antioxidant activity.
Also, many studies show that the two combinations can reduce vascular damage and attenuate the inflammatory process. One research has suggested that micronized palmitoylethanolamide(PEA) 400mg, and polydatin 40mg twice daily, have good effectiveness in chronic pelvic pain.
Also, polydatin can be combined with grape seed extract(OPC), piperine, quercetin, Nicotinamide Mononucleotide(NMN), etc. in dietary supplements.
Flowchart for Polydatin Extraction
The dried Polygonum cuspidatum root is pulverized, extracted with ethanol as the solvent, concentrated, crystallized, dried, smashed, obtained the crude polydatin, then packaged and put into the warehouse after testing.
Polydatin is Safe?
As a dietary supplement,polydatin does not apply with GRAS currently, but it was viewed as safe by many clinical trials; for injection grade, a company called Shenzhen Neptunus Bioengineering has submitted the USFDA application. And it is also could as an ingredient used in cosmetic products according to European Union law.
Because it has not pointed out the correct dosage of polydatin, we can find out through market applications, such as BioForte, PTEROMAX™(by Biotivia), polydatin dosage range from 5mg~100mg, combined with Resveratrol and Pterostilbene.
Polydatin is a rising material in the dietary supplement market, and no adverse effects report yet.
Prices for Polydatin≥98% powder
As an active component, polydatin was isolated from Polygonum cuspidatum. The raw material impacts on production, so polydatin prices are unstable. Here, we can share a general pricing range of USD420 to USD500 for your reference. Get a quote on your custom quantity and delivery destination now!
Where to Buy Polydatin Powder?
Cima Science is a genuine factory and supplier of natural products in China, and polydatin is one of its key ingredients. Due to the limitation of raw materials, there are no more than three real manufacturers of polydatin in China, but WUXI CIMA SCIENCE has excellent advantages in supplying it. Each batch has 200-300 kg produced with 98%fine white powder by HPLC, top quality, none excipient, has great control in heavy metals, microorganisms, solvent residues, and so on.