What is Neohesperidin dihydrochalcone?
Neohesperidin dihydrochalcone powder, also known as Neohesperidin DC, Neo-DHC, and NHDC for short, is an enhanced sweetener produced by neohesperidin. NHDC is considered a high-strength, non-nutritive sweetener with a pleasant taste; it can improve the sweetness and quality of different food recipes.
Neohesperidin dihydrochalcone is a compound that is roughly 1500-1800 times sweeter than sugar at threshold concentrations, and it weighs about 340 times sweeter than sugar.

Neohesperidin dihydrochalcone is usually used in food additives industries and dietary supplements.
Discover and source of Neohesperidin dihydrochalcone
Neohesperidin dihydrochalcone was found in the 1960s as part of a U.S. Department of agriculture research project to find ways to minimize the bitterness in citrus juices. Neohesperidin is such a bitter component that exists in the peel and pulp of bitter oranges and other citrus fruit; it is also an active flavonoid ingredient of citrus aurantium fruit. When treated with potassium hydroxide or some other strong base and then hydrogenated, it becomes Neohesperidin dihydrochalcone (NHDC).

NHDC does not occur in nature.
Neo-DHC is hydrogenated from natural neohesperidin—a natural source, but it underwent chemical transformations, so it is not a natural product.

Neohesperidin dihydrochalcone VS other sweeteners
Different sweetness and taste
Compared with the sucrose, neohesperidin DC is roughly 1500-1800 times sweeter than sugar and 1,000 times sweeter than the sucrose, while sucralose is 400-800 times and ace-k is 200 times sweeter than sugar.
Neohesperidin DC tastes clean and has a long aftertaste. Like other high-sugar glycosides, such as glycyrrhizin found in stevia and those from the licorice root, NHDC’s sweetness is slow in onset than sugar’s and lingers in the mouth for a long time.

Good stability and high safety
NHDC is stable under high temperature, acidic or alkaline conditions and therefore can be used in applications requiring a longer shelf life. NHDC can keep food safe for up to five years under optimal conditions
Different receptors
Human perception of sweetness and taste is mediated by T1Rs, the first family of GPCRs, TIRs are expressed in gustatory of the soft palate and tongue, including TIR1, T1R2, and TIR3, which are often found in the form of dimers. The dimer T1R1-TIR3 is an amino acid receptor, which expresses and participates in taste recognition. The dimer T1R2-T1R3 is a sweet receptor, which participates in sweet taste recognition.
Sweeteners such as sucrose, aspartame, saccharin, and cyclamate work on the extracellular structure region of T1R2. NHDC and cyclamate act on the transmembrane part of T1R3 to produce sweetness. Neohesperidin DC interacts with specific amino acid residues in the transmembrane region of T1R3 to induce its own sweetness and at the same time, it can induce the synergistic sweetening effect of the dimer T1R2-T1R3. As a sweetener, NHDC has a significant sweetening effect when it is compounded with other sweeteners with a small number of ingredients.

Besides, Neohesperidin DC differs from traditional sweeteners in its functions of sweetening, aroma enhancement, bitterness concealment, and flavor modification.
Producers and manufacturers of Neohesperidin dihydrochalcone (NHDC)
Cima already has a production line of neohesperidin, NHDC is one of the new products CIMA developed for our customers. Many years of experience guarantee the quality of the products and the processes of production in CIMA.
NHDC and neohesperidin manufacturing, as well as all our finished products, meets international quality standards. For any further information or other queries about Neohesperidin DC, please feel free to contact us. We will be pleased to help and assist you!
FAQ:
A: What are the current applications of NHDC in the market?
- As a sweetener and taste enhancer: Desserts, ice cream and dairy products; Beverage, soft drinks and juice industries; Candies.
- Flavoring agent: Sauces and soups and animal feed and health industries.
- Pharmaceutical industry: a masking agent—cover up the bitter
- Personal care products: mouth rinses, toothpaste
A:Can NHDC replace other sweeteners?
NHDC is an efficient, non-toxic, and low-calorie sweetener which can improve flavor and inhibit bitterness. However, it has some other characteristics that limit its use as a sweetener. First, it has a strong cooling effect on the tongue. Second, It has a licorice-like and bitter taste. Third, it has a slower onset and a lingering taste that makes it different from sucrose.
A: What’s the advantage of Neohesperidin dihydrochalcone respect to other sweeteners?
- High efficiency: Neohesperidin DC a sweetener of natural origin with higher sweetness intensity in Low concentrations. It has a lingering taste than other sweeteners.
- Healthy: NHDC is non-caloric. Also, the glycemic index of NHDC is zero. This advantage makes neohesperidin DC suitable for a broader range of products than other sweeteners, including products for people with pathological conditions associated with obesity or metabolic syndrome.
- Stability: It is more stable under high temperature, acidic, or alkaline conditions that allow Neohesperidin DC to be used in different industries and different stages of the production process.
- Costs savings: Neohesperidin DC can achieve the desired effect in low doses and is synergistic with other more expensive sweeteners.
- Flavor enhancer: As a flavor enhancer, the flavonoids play a role by increasing the flavor of fruits and cocoa derivatives. Its pleasant and intense sweetness of NHDC makes it widely used in different fields and industries; it can reduce unpopular flavors in various food formulations, such as sour, bitter, etc.



