What is Astragalus Root Extract?
Astragalus Propinquus is a flowering plant belonging to Fabaceae.
Astragalus Membranaceus is one of the 50 basic herbs used in traditional Chinese Medicine (TCM) with more than a thousand years of history.
We use it to reinforce Qi, strengthen the superficial resistance, promote the discharge of pus, and help the growth of new tissue.
Astragalus Membranaceus Applications
Most ingredient suppliers make the root of Astragalus Membranaceus into powder and liquid extracts.
Some people use astragalus as a general tonic to protect the liver and fight bacteria and viruses. It is also used to reduce the side effects associated with cancer treatment.
Doctors sometimes inject Astragalus Propinquus into the vein to fight the side effects of cancer treatment, heart failure, diabetes, and lupus (systemic lupus erythematosus).
You can also apply astragalus to the skin to increase blood flow to the area and speed wound healing.
Many health brands supply astragalus root extract capsules in combination with other herbs.
Astragalus Propinquus Specifications
Astragalus Mongholicus include triterpenoids (such as astragalosides),
Isoflavones(including kumatakenin, calycosin, and formononetin),
polysaccharides, glycosides, and malonates.
|
Astragalus Membranaceus |
Astragalus Saponins |
Astragaloside IV(0.30-99.00%) |
| Total Saponins of Astragalus (1.00-99.00%) | ||
| Cycloastragenol(1.00-99.00%) | ||
|
Astragalus Flavone |
Calycosin-7-O-beta-D-glucoside(0.30-5.00%) | |
| Astragalus Polysaccharides(APS) | 70% | |
| Astragalus Root Extract | 4:1 to 20 :1 |
Astragaloside IV Powder
| Product Name |
Astragaloside IV |
| Other Name | Astrasieversianin XIV |
| CAS Number | 84687-43-4 |
| Molecular Formula | C41H68O14 |
| Molecular Weight | 784.97 |
| Appearance | Brown yellow powder (0.3%,1%,5%,10%,20%,50%), Light yellow powder(70%,90%),White powder (98%) |
| Mechanism | Telomerase Activator |
| Chemical structure |  |
More and more people in different countries use Astragaloside IV capsules as a safe dietary supplement although FDA and GRAS haven’t reorganized it.
Astragaloside IV is a saponin extracted from the root of Astragalus Membranaceus.
You may know the lowest specification of astragaloside IV(CAS number 84687-43-4)is 0.3%, the highest spec is 98%, and the pervasive item is astragaloside IV at 95%. However, if you need other content, you can get them from Cima Science.
How does Astragaloside IV (CAS NO.84687-43-4) work?
Astragaloside IV has supper power in protecting telomeres integrity and remitting toxins that cell damage caused.
As you know, the telomere is the protective structure at the end of each chromosome. It is directly associated with youth. As we age, the area of the chromosome (telomere) becomes shorter over time. The shortening will lead to impaired cellular and disordered tissue function.
The cell produces new cellular by replicating DNA.
Once DNA splits to produce its copy, this process will cause a little damage to the genetic material, and these DNA strands will eventually be separated, resulting in many dysfunctional cells.
Telomeres cover the ends of the DNA strand to help the DNA strand lock well. But over time, telomeres will be shortened by DNA replication and oxidative damage. When most telomeres are too short to finish DNA replication, it will cause significant damage to surrounding tissues. Then aging and disease will attack us.
Clinical researches indicate that Astragaloside IV powder can lengthen the telomeres.
Cycloastragenol Powder
| Product Name | Cycloastragenol |
| Other Name | Cyclogalegigenin, Astramembrangenin |
| CAS Number | 78574-94-4, 84605-18-5 |
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.72 |
| Appearance | Brown yellow powder (5%, 10%), Light yellow powder (50%, 90%), White powder (98%) |
| Mechanism | Telomerase Activator |
| Chemical structure |  |
What is Cycloastragenol(CAG)?
Cycloastragenol (CAG) is the hydrolysate of Astragaloside IV. Their benefits are very similar.
TA Sciences launched Cycloastragenol as a medical food (GRAS recognized as safe ) in the name of TA-65 in 2007 in the US.TA 65 or TA65 has been the most common name for Cycloastragenol based on those many years of market promotion.
Cycloastragenol application
Have you used any astragalus extract before?
Lots of brands use Cycloastragenol powder is in a relatively new anti-aging dietary supplement, cosmetics formulas, and luxury skincare due to its antioxidant.
Cycloastragenol method of action
Nobel Prize winners in 2009 covered telomeres and telomerase mechanisms to safeguard chromosomes relating to human aging and health. Alzheimer’s, brittle bones, and cancer may appear if telomeres keep shortening.
You’ll get a telomeres booster if you’re using this astragalus supplement.
Hundreds of researchers reported that Cycloastragenol could help maintain the length of telomeres. It has multiple benefits for the body’s health, such as promoting the immune system, cell longevity, overall health, etc.
Some scientists believe Cycloastragenol（CAS#84605-18-5）can enable a longer human lifespan.
You may find the mechanism of Cycloastragenol is almost the same as Astragaloside IV since they both effect as a telomerase activator.
Manufacturing Flow Chart of Cycloastragenol
We buy the dried Astragalus Root from the supplier, then inspect them to get a high quantity of raw material for cycloastragenol.
Later we smash the root into powder via machine, Water Extraction, Resin Adsorption, Resin Adsorption, Rinse With Ethanol, Membrane filtration, and Enrichment, then we get Astragaloside IV, Hydrolysis it, Crystallize to reach Cycloastragenol.
Cycloastragenol VS Astragaloside IV
Cycloastragenol and astragaloside IV are both from the extract of Astragalus Membranaceus.
We obtain Cycloastragenol by hydrolysis of astragaloside IV.
Both astragaloside IV and Cycloastragenol are telomerase activators with similar functions and benefits.
They have a similar structure, but Cycloastragenol has a lower molecular weight and higher bioavailability.
Therefore, the price of Cycloastragenol 98% powder is five times higher than Astragaloside IV 98% powder.
Besides, the effect of Cycloastragenol 98% appears to be potent ten times more than Astragaloside IV 98%.
The effect of 50 mg Astragaloside IV 9 equals 5 mg Cycloastragenol.
In conclusion, Cycloastragenol is an upgraded version of astragaloside IV with more bioactivity and higher cost.
Calycosin-7-O-beta-D-glucoside Powder
| Product Name | Calycosin-7-O-beta-D-glucoside |
| Other Name | fCalycosin-7-O-β-D-glucoside; Calycosin 7-glucoside, 4-hydroxy-3-Methoxyisoflavone-7-sug, 3′-hydroxy-4′-methoxy isoflavone 7-sug |
| CAS Number | 20633-67-4 |
| Molecular Formula | C22H22O10 |
| Molecular Weight | 446.408 |
| Appearance | Brown yellow powder |
| Chemical structure |  |
Astragalus Propinquus extract benefits
- Hold back aging and increase life expectancy
- Support Cardiovascular Health
- Boost Immune and maintain healthy immunity
- Improve Inflammatory Response
- Increase your energy level.
- Better sleep quality.
Recommended dosage
You’ll get the double effect if you take astragaloside IV alongside Cycloastragenol.
- Astragaloside IV, 50-100mg per day
- Cycloastragenol, 10mg to 50mg per day
- Astragalus Root Extract, 250mg to 1000mg per day.
Caution
You’d better not intake astragalus Membranaceus if you’re pregnant, nursing women, children, or those with severe liver or kidney disease.
FAQ:
Cima Science Astragalus membranaceus descriptions
- Premium Extract
- Non-GMO Project Verified
- Gluten-Free
- 100% natural extract of astragalus
Where to buy Astragalus Root Extract?
Are you interested in Astragalus extract? Would you like to see the price or sample for reference? We are here for you with competitive prices, free samples, and technical support.
Cima Science Co., Ltd is a well-established, Technology-oriented, fast-growing ingredients manufacturer based in Wuxi, China. As one of China’s leading herbal extract and chemical nutrition providers, we have maintained long-term stable cooperation with several famous brands related to food supplements, cosmetic products, and medical devices.
Reference:
- Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)
- Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator
