Most people who drink alcohol know the pain of hangover: headache, dizziness, fatigue, nausea, stomach discomfort, sleepiness, sweating, thirst, and cognition.
Here is a dietary supplement that can greatly alleviate your hangover, not only let you feel the beauty of the wine, vodka, rum, whiskey, and not afraid of the discomfort caused by excessive drinking.
This is Dihydromyricetin (DHM), a natural gift from the ancient oriental plant of vine tea.
What is dihydromyricetin (DHM)?
Dihydromyricetin, also known as snake glucose, is a particular flavonoid extracted from vine tea or Hovenia Dulcis. Let us first know about it:
Look at its Structural formula:
Know about DHM’s physical and chemical properties:
White needle crystal, soluble in hot water, hot ethanol and acetone, also soluble in ethanol and methanol, but rarely soluble in ethyl acetate, insoluble in chloroform, petroleum ether. Microherb studies have told that dihydromyricetin has excellent thermal stability, but irreversible oxidation occurs when dihydromyricetin is more than 100 °C. DHM is stable under neutral and acidic conditions.
These substances have many unique effects such as scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, anti-inflammatory and so on. It is called unique because it has the following characteristics in addition to the general features of flavonoids:
- The widespread flavonoids are insoluble in water, soluble in ethanol (alcohol), and DHM is readily soluble in hot water, which means that DHM in vine tea can be soaked out with boiling water and have more effective;
- In addition to the action of general flavonoids, dihydromyricetin has the functions of relieving alcoholism, preventing alcoholic liver, fatty liver, inhibiting the deterioration of liver cells, and reducing the incidence of the liver cancer; it is a right product for protecting the liver and protecting liver and hangover.
- Dihydromyricetin has a low molecular weight (320), which is easier to pass through the blood-brain barrier and has a fast onset.
What is vine tea?
Vine tea, commonly known as berry tea, is a wild vine belonging to the genus Vitis. It is not only a pure natural green drink but also a tea with potent medicinal properties. It is rich in flavonoids, amino acids, vitamins, and essential trace elements. It has the functions of softening blood vessels, sterilizing and anti-inflammatory, and long-term drinking can eliminate sub-health of the human body. It has been a history of folk drinking for thousands of years, and it has been cultivated for hundreds of years. For thousands of years, it was the favorite of the aristocrats of the princes, and it was also the heart of the field farmer.
According to nutrition and tea experts, vine tea is rich in phytonutrients. Among them, dihydromyricetin has outstanding heat-clearing and detoxification, dilating throat, anti-bacterial and anti-inflammatory, anti-influenza hepatitis B virus and assisting the “three high” prevention and treatment of cardiovascular and cerebrovascular diseases.
Vine tea extract VS Hovenia dulcis extract
|Vine tea||Hovenia Dulcis|
|Content||About 16%||Highest is only 1%|
|Extract specification||50%, 95%, 98%||10%-20%|
|extraction cost & price||Substantial||About 10 times more than vine tea|
Hovenia dulcis is not the major source for dihydromyricetin since it’s low in content and high in cost. Vine tea is the best choice.
How does DHM relieve drunkenness and hangovers?
DHM can enhance your body’s natural ability to break down alcohol, so you won’t have morning- fog and sleepiness when you wake up.
What is the relationship between alcohol breakdown and your second-day sensation?
An institution named “The National Institute of Alcohol Abuse and Alcoholism” has a lot of questions entitled《 Alcohol Metabolism: A Update》.
The study describes the primary process of alcohol breakdown. We are here to summarize the necessary parts for you.
Two enzymes—alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase( ALDH)—help your body break down alcohol.
When you first start drinking, ADH breaks down alcohol to acetaldehyde, a highly toxic and carcinogenic substance.
Next, ALDH further metabolizes acetaldehyde into an acidic by-product called acetate, which is then broken down into the water and safely discharged from your body.
So why do you feel so uncomfortable in the morning after drinking the night of wine?
When you drink more than the amount of liver that can be broken down, the toxins caused by these alcohols will pile up and put a lot of pressure on your body.
The longer these toxins are in your body, the worse you will feel the next day before metabolism and safe excretion.
In other words, prolonged toxic substances are exposed in your body and can increase the sequelae of drinking.
DHM comes to rescue!
This powerful flavonoid helps protect the liver (and your feelings the next day) by speeding up the metabolism of alcohol.
How do we know?
Studies have shown that Vine tea extract DHM can increase the activity of ADH and ALDH in the liver, allowing the body to metabolize and excrete alcohol and toxins more quickly.
Then you wake up and feel refreshed and ready for a new day!
How DHM and alcohol affect the brain?
Alcohol has a lot of effects on the brain.
The first break breaks the delicate balance between the two neurotransmitters:
gamma-aminobutyric acid (GABA) and glutamate.
What is GABA?
GABA is a naturally occurring non-protein amino acid that is an important inhibitory neurotransmitter in the mammalian central nervous system. It plays an essential role in the human cerebral cortex, hippocampus, thalamus, basal ganglia and cerebellum, and has a regulating effect on various functions of the body. That is to say, when the body’s GABA deficiency, it will produce anxiety, anxiety, fatigue, anxiety and other emotions.
As an inhibitory neurotransmitter, GABA can effectively inhibit the excessive secretion of excitatory neurotransmitters such as dopamine, leaving people in a state of relaxation, lowering blood pressure, slowing heartbeat, and calming mood.
In other words, GABA is a substance that relaxes people’s mind and body.
When alcohol binds to the GABA receptor, it activates the GABA receptor, causing a high degree of relaxation, reduced inhibition, ambiguity, and loss of motor control.
This behavior makes the brain think that there is more GABA in the system than usual.
Then your body tries to reduce the GABA content to restore balance.
But the next morning when alcohol leaves your order, you may experience a rebound effect that can cause anxiety, difficulty sleeping, and lack of concentration.
DHM ensures that alcohol affects the brain’s GABA receptors as little as possible, so this reaction does not occur and you won’t experience rebound or hangover symptoms the next day.
DHM can accelerate the decomposition of acetaldehyde and protect the liver.
Dihydromyricetin is also difficult to support the liver to break down toxic chemical acetaldehyde as soon as possible.
When you drink alcohol, the body breaks it down into smaller chemicals until all the by-products have entirely disappeared.
However, one of the compounds is called acetaldehyde, which is 20 times more toxic than alcohol.
High concentrations of acetaldehyde in your system may cause some uncomfortable symptoms and increase hangover symptoms the next day.
When your body is full of acetaldehyde, your liver can only remove it quickly. However, DHM can help your body break down acetaldehyde faster, so you can get back to regular faster.
When should I take it, before or after drinking?
When you take dihydromyricetin, it depends on the task you are trying to accomplish.
Thus, for example, the researchers found that taking a relatively large dose before drinking alcohol reduced the level of alcohol in the blood by 55%.
However, for most people, we recommend making it immediately after drinking, which is an excellent way to reduce the hangover symptoms that are usually felt the next day.
Taking DHM after drinking alcohol can also block the GABA rebound effect, regularly awakening you in the middle of the night, or anxious about you the next day.
So taking DHM immediately after drinking means that the adverse effects of alcohol will diminish.
Is dihydromyricetin effective and what is the best dosage?
Yes. There is sufficient scientific evidence to suggest that dihydromyricetin is effective in reducing the effects of poisoning and reducing hangovers and supporting the liver.
The real question is, what is the most suitable dose?
An alcohol extract of 125 mg/kg body weight has been used in capable rats, which translates to an estimated human dosage of 9-9.3 mg/lbs human weight,
1, 400mg for a 150lb person
2, 800mg for a 200lb person
3, 1200mg for a 250lb people
These are the estimated human maximum doses based on rat studies.
However, the following factors should be considered when using the dosage:
The number of alcoholic beverages you have ever eaten
The alcohol content in the beverage is exhausted
How fast do you drink?
Have you ever eaten?
In reality, it also depends on what you want to achieve with DHM because the dose required to reduce poisoning is much higher than the dose after drinking to eliminate hangovers.
Supplements containing dihydromyricetin:
Where to buy dihydromyricetin?
Wuxi Cima Science Co., Ltd is the manufacturer of dihydromyricetin extracted from natural Vine Tea, or other sources as the demand of our clients.
Cima can offer the specification of dihydromyricetin 50%, 90%, 95%, and 98%. If you need to know more about DHM like COA, MSDS, and price, please contact us via email, and we will get back in 12 hours.
Packing Detail: Packed in paper drums and two plastic bags inside.
Net Weight: 20kg/drum.
Storage Situation: Stored in a well-closed container away from moisture and direct sunlight.
Shelf Life: Two years if sealed and stored properly.