What is Tranexamic Acid?
Tranexamic Acid is a synthetic amino acid derivative widely used in cosmetics and pharmaceuticals for brightening, anti-pigmentation, and anti-inflammatory benefits. Although it is not derived from botanical or food sources, Tranexamic Acid is produced through controlled chemical synthesis to ensure high purity and consistent quality. Known by other names such as TXA, Trans-4-aminomethylcyclohexanecarboxylic acid, and AMCHA, it carries the CAS number 1197-18-8, a molecular formula of C8H15NO2, and a molecular weight of 157.21 g/mol.
Cima Science supplies 99% HPLC-tested Tranexamic Acid, meeting stringent specifications to comply with cosmetic and pharmaceutical formulation standards. The ingredient appears as a white crystalline powder that is freely soluble in water, offering good formulation compatibility, though its oral bioavailability is moderate compared with topical use. Our bulk material is packaged in 25 kg fiber drums with inner liners for stability and moisture protection. As the leading bulk Tranexamic Acid powder supplier in China, Cima Science also provides OEM services, including capsules, tablets, blends, and customized formulations for brands and manufacturers worldwide.
Tranexamic Acid vs Azelaic Acid
Both Tranexamic Acid (TXA) and Azelaic Acid are popular brightening and anti-pigmentation ingredients, but they work differently and suit different formulation goals.
- Tranexamic Acid is more potent for melasma, dark spots, and stubborn hyperpigmentation, even at low concentrations (2–5%). It is exceptionally gentle and ideal for brightening serums, ampoules, and premium cosmetics.
- Azelaic Acid is a multi-functional ingredient that helps with acne, redness, and mild pigmentation, but requires higher concentrations (10–20%) and may cause irritation.
- In terms of stability, ease of formulation, and premium whitening results, Tranexamic Acid is generally better for high-performance cosmetic products, while Azelaic Acid is better for acne-prone, sensitive, or multifunctional skincare.
| Item | Tranexamic Acid | Azelaic Acid |
|---|---|---|
| CAS Number | 1197-18-8 | 123-99-9 |
| Other Names | TXA, Trans-4-aminomethylcyclohexanecarboxylic acid | Nonanedioic acid |
| Molecular Formula | C8H15NO2 | C9H16O4 |
| Molecular Weight | 157.21 g/mol | 188.22 g/mol |
| Appearance | White crystalline powder | White to off-white powder |
| Botanical / Food Sources | None (synthetic amino acid derivative) | Found naturally in wheat, rye, barley (in very small amounts) |
| Purity / Specifications | ≥99% HPLC, cosmetic & pharma grade | ≥98% purity, cosmetic & pharma grade |
| Solubility in Water | Freely soluble | Poorly soluble (requires solubilizers or special delivery systems) |
| Bioavailability (Topical) | Moderate to high (excellent skin penetration when formulated properly) | Low to moderate (improves with encapsulation or solubilizers) |
| Potency for Hyperpigmentation | Very strong (blocks melanocyte activation) | Moderate (reduces tyrosinase activity, anti-inflammatory) |
| Recommended Cosmetic Dosage | 2–5% | 10–20% |
| Half-Life | ~2 hours (topical) | ~12 hours (topical) |
| Stability in Formulations | Highly stable in water-based formulas | Less stable; requires pH control and special formulation |
| Irritation Potential | Very low | Moderate (may cause tingling or burning) |
| Popularity in Skincare | Rapidly rising; widely used in brightening serums and ampoules | Popular for acne treatment and rosacea-friendly skincare |
| Primary Skin Benefits | Strong brightening, melasma reduction, anti-pigmentation, anti-inflammatory | Anti-acne, pore-clearing, anti-inflammatory, mild brightening |
| Pricing (Bulk B2B Range) | Medium–High (premium brightening ingredient) | Low–Medium (commodity ingredient) |
| Formulation Complexity | Easy (water-soluble) | Difficult (low solubility, requires special techniques) |
| Best for | High-end brightening products, melasma, dark spot correctors | Acne-prone skin, sensitive skin, rosacea, multipurpose formulas |
tranexamic acid vs hydroquinone
Hydroquinone has long been considered the strongest depigmenting agent, but its safety concerns, potential for irritation, and regulatory restrictions have led many brands to shift toward safer alternatives, such as Tranexamic Acid (TXA).
Tranexamic Acid offers safer, gentler, and more stable brightening effects, especially for melasma and post-inflammatory hyperpigmentation. It works well at low concentrations (2-5%), is suitable for sensitive skin, and is allowed globally.
Hydroquinone, while highly potent, can cause irritation, rebound pigmentation, and long-term risks, and is restricted or banned in many countries for cosmetic use.
Overall, Tranexamic Acid is the better ingredient for modern cosmetic formulations, while Hydroquinone is mainly used in medical or prescription-based treatments under clinical supervision.
Tranexamic Acid Benefits
Tranexamic Acid (TXA) is a highly effective and well-tolerated brightening ingredient widely used in modern skincare and cosmetic formulations. It works through multiple pathways that reduce pigment formation, calm inflammation, and prevent new dark spots from forming. Because it delivers strong results even at low concentrations, TXA is ideal for high-performance serums, ampoules, creams, and targeted dark spot correctors.
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Powerful Brightening Effect
Helps inhibit melanin transfer between melanocytes and keratinocytes, resulting in a brighter and more even skin tone. -
Effective for Melasma and Stubborn Pigmentation
Clinically shown to improve melasma, sunspots, and post-inflammatory hyperpigmentation without the harsh side effects associated with stronger agents. -
Reduces Dark Spots and Discoloration
Helps fade age spots, acne marks, and uneven pigmentation by targeting the mechanisms that trigger excess melanin. -
Anti-Inflammatory Support
Helps calm redness and soothe irritated skin, which is beneficial after breakouts or environmental stress. -
Suitable for Sensitive Skin
Very gentle compared to ingredients like hydroquinone, azelaic acid, and retinoids. Safe for long term daily use. -
Helps Strengthen the Skin Barrier
Supports a healthier protective barrier, improving smoothness and overall skin resilience. -
Boosts Radiance and Clarity
Promotes a more luminous and refined complexion with consistent application. -
Works Well With Other Actives
Compatible with niacinamide, vitamin C derivatives, arbutin, kojic acid, and azelaic acid for enhanced brightening benefits. -
Stable and Easy to Formulate
Water-soluble and formulation-friendly, ideal for lightweight skincare products such as serums and essences. -
Improves Overall Skin Tone Uniformity
Helps reduce patchiness and uneven coloration for a smoother-looking complexion.
Where to buy bulk Tranexamic Acid Powder?
You can buy bulk Tranexamic Acid powder directly from Cima Science, a leading manufacturer and wholesale supplier in China. Our factory provides high purity material for skincare formulas, brightening products, and tranexamic acid 650 mg tablet production. We offer competitive bulk pricing, free samples, and third-party lab test reports for every batch.
Cima Science supplies Tranexamic Acid in bulk and supports OEM and custom services, including capsules, tablets, and finished formulations. Buying directly from our factory ensures stable quality, fast delivery, and reliable supply for brands, distributors, and contract manufacturers.
Contact Cima Science today for bulk orders, wholesale prices, or a free sample.
