What is Ascorbyl Tetraisopalmitate?
Ascorbyl Tetraisopalmitate (ATIP) vs Tetrahexyldecyl Ascorbate (THD)
Both ATIP and THD are highly stable, oil-soluble Vitamin C derivatives, ideal for skincare formulations targeting brightening, anti-aging, and antioxidant protection. Tetrahexyldecyl Ascorbate (THD) is generally considered more potent, more bioavailable, and more widely used in premium skincare. It penetrates deeper into the skin and converts more efficiently to active Vitamin C.
Ascorbyl Tetraisopalmitate (ATIP) is also excellent – highly stable, gentle, and suitable for sensitive formulations, but THD typically delivers stronger results in brightening and collagen support.
If a brand needs maximum efficacy, choose THD.
If the priority is stability + gentleness, ATIP is an excellent choice.
| Item | Ascorbyl Tetraisopalmitate (ATIP) | Tetrahexyldecyl Ascorbate (THD) |
|---|---|---|
| CAS Number | 183476-82-6 | 183476-82-6 (same CAS used commercially) |
| Other Names | VC-IP, Tetra-Isopalmitate Ascorbate | THD Ascorbate, Tetrahexyldecyl Vitamin C |
| Molecular Formula | C70H128O10 | C70H128O10 |
| Molecular Weight | ~1129 g/mol | ~1129 g/mol |
| Appearance | Light yellow to yellow oily liquid | Pale yellow to yellow oily liquid |
| Natural Food Sources | Not naturally occurring; synthetic derivative | Not naturally occurring; synthetic derivative |
| Specifications (Common) | 90%–98% | 90%–98% |
| Purity | Typically ≥95% | Typically ≥95% |
| Bioavailability | Moderate to high; good penetration | High; better skin penetration than ATIP |
| Potency | Strong antioxidant; effective but slightly less active than THD in vivo | Very strong; considered the most potent oil-soluble Vitamin C derivative |
| Recommended Dosage in Skincare | 1%–10% | 0.5%–10% |
| Half-Life | Long due to high oxidative stability | Long, but slightly less than ATIP in some storage conditions |
| Stability | Excellent thermal and oxidative stability; very stable in oils | Very stable but can degrade slightly faster than ATIP under extreme heat |
| Solubility | Oil-soluble | Oil-soluble |
| Popularity in Market | Moderate to high; used in serums, oils, and emulsions | Very high; widely used in premium brightening and anti-aging formulas |
| Pricing (Bulk, Large Range) | Medium to high cost; $40–$140/kg depending on purity and origin | Higher cost; $60–$180/kg depending on grade and supplier |
| Key Benefits | Skin brightening, antioxidant protection, supports collagen, reduces UV damage | Strong brightening, deep penetration, excellent collagen support, reduces dark spots, strong antioxidant |
| Irritation Level | Very low; suitable for sensitive skin | Low; usually tolerated well, but slightly more active |
| Conversion to Pure Vitamin C (Ascorbic Acid) | Moderate | High (more efficient conversion) |
| Typical Applications | Facial oils, serums, sunscreens, emulsions | High-end serums, brightening products, anti-aging creams, acne scar treatments |
| Regulatory Status | Globally accepted | Globally accepted |
VC-IP Benefits
Ascorbyl Tetraisopalmitate (ATIP) is a premium oil-soluble Vitamin C derivative known for its exceptional skin penetration, stability, and gentle yet powerful brightening effects. Unlike pure ascorbic acid, ATIP remains stable in formulations and effectively converts to active Vitamin C once absorbed, making it highly effective for anti-aging, collagen support, and skin-tone improvement. It is suitable for all skin types, including sensitive skin, and is frequently used in high-end serums, creams, and facial oils.
- Provides strong antioxidant protection to fight free radicals
- Brightens dull skin and promotes an even skin tone
- Helps reduce the appearance of dark spots and hyperpigmentation
- Boosts collagen synthesis for firmer and smoother skin
- Improves skin elasticity and reduces signs of aging
- Highly stable in formulations, even at high temperatures
- Oil-soluble, allowing deeper penetration into the skin barrier
- Gentle on sensitive skin with very low irritation potential
- Enhances UV protection when used with sunscreen
- Supports repair of sun-damaged skin
- Helps reduce inflammation and redness
- Compatible with most skincare ingredients, including retinol and niacinamide
Ascorbyl Tetraisopalmitate Liquid Manufacturing Process
Cima Science produces high-purity 99% Ascorbyl Tetraisopalmitate (ATIP) Liquid through a tightly controlled esterification and purification process. Our production follows international GMP standards, and every batch is verified by third-party laboratories to ensure potency, purity, and safety. The entire process is designed for maximum stability, minimal impurities, and consistent quality suitable for cosmetics, skincare, and high-end formulations.
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Raw Material Screening and Verification
High-purity Vitamin C and pharmaceutical-grade isopalmitic acid are sourced from certified suppliers. Each raw material undergoes identity testing, purity analysis, and contaminant screening before production begins. -
Esterification Reaction
Vitamin C undergoes a controlled esterification with isopalmitic acid under optimized catalytic conditions. Reaction temperature, pH, and vacuum pressure are precisely monitored to ensure maximum conversion into Ascorbyl Tetraisopalmitate. -
Reaction Completion and Neutralization
Once the reaction reaches the target conversion rate, the mixture is cooled and neutralized to stop further reactions. This stabilizes the product and prevents unwanted by-products. -
Solvent Removal and Concentration
Food-grade, cosmetic-approved solvents used during synthesis are carefully removed using low-temperature vacuum evaporation. This step ensures no residual solvents remain in the final ATIP concentrate. -
Purification and Molecular Filtration
The crude ATIP liquid is purified using multi-stage filtration and molecular refining. This eliminates impurities, color residues, unreacted materials, and micro-contaminants. -
Deodorization and Color Adjustment
Gentle deodorization ensures a clean, cosmetic-friendly odor profile. Color is standardized to meet global cosmetic ingredient specifications. -
Quality Control & Analytical Testing
Each batch undergoes strict testing, including:
- HPLC purity analysis (≥ 99%)
- GC-MS impurity profile
- Heavy metals screening
- Residual solvent testing
- Microbial limits
- Stability and oxidation resistance
Testing is performed both internally and by third-party labs to ensure global compliance.
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Stability Conditioning
The purified ATIP liquid is conditioned under inert nitrogen and stored in controlled environments to maintain maximum stability and prevent oxidation. -
Filling & Packaging
The finished Ascorbyl Tetraisopalmitate Liquid is filled into light-resistant, airtight containers. Packaging is done in a GMP-certified cleanroom to protect the ingredient from contamination, moisture, and oxidation. -
Final Inspection & International Standard Compliance
All finished goods undergo final review to ensure they meet:
- International cosmetic ingredient regulations
- Export standards
- Customer-specific specifications
- Third-party test requirements
Only after passing all inspections is the batch released for shipment.
Where to buy bulk Ascorbyl Tetraisopalmitate Liquid?
Wuxi Cima Science Co., Ltd. is one of the leading ascorbyl tetraisopalmitate manufacturers in China, supplying high-purity Ascorbyl Tetraisopalmitate Liquid 99% to global skincare, cosmetics, and nutraceutical brands. As a china ascorbyl tetraisopalmitate factory, we provide stable quality, competitive high quality Ascorbyl Tetraisopalmitate price, and full OEM support for capsules, tablets, serums, and oil-based formulations.
We offer ascorbyl tetraisopalmitate bulk and ascorbyl tetraisopalmitate solution at wholesale pricing with flexible MOQs. All products come with GMP, Kosher, Halal, and full certificates, along with third-party testing reports for purity, safety, and identity. Free samples are available for formulation testing.
As a professional ascorbyl tetraisopalmitate supplier, Cima Science provides direct-from-factory production, stable supply, and customized OEM services for brand owners, distributors, and private-label skincare companies. If you are looking for reliable ascorbyl tetraisopalmitate manufacturers in China, Cima Science is your trusted partner for bulk and wholesale orders.
Contact us today for quotations, COAs, and bulk Ascorbyl Tetraisopalmitate Liquid supply support.
