Tangeretin is a flavonoid that comes from citrus fruit peels. It has been proven that Tangeretin plays a vital role in anti-inflammatory responses and neuroprotective effects from several disease models.
Take rats as an example to study Tangeretin bioavailability:
The results show that the absolute oral bioavailability of tangeretin in rats was 27.11%. The main components are concentrated in the kidney, lung, and liver. And less than 8% of tangeretin is excreted in their urine or feces.
The low solubility of Tangeretin may be one of the main reasons for the low bioavailability of Tangeretin in human bodies.
TANGERETIN vs Sinensetin
Tangeretin and sinensetin have the same molecular formula but different molecular structural formulas and functions for our bodies. In several disease models, Tangeretin has been proven to play a pretty important role in neuroprotective effects and anti-inflammatory responses. Sinensetin can enhance adipogenesis and lipolysis. What’s more, it possesses potent antiangiogenesis and anti-inflammatory.
- 95% ~99% Tangeretin powder
- 98% Tangeretin powder
- nobiletin + tangeretin >20% Hplc
- nobiletin + tangeretin >30% Hplc
- nobiletin + tangeretin >60% Hplc
- Shipment (by Courier like FedEx, UPS, by air, by sea)
- Package (1kg/bag, 25kg/drum)
Polymethoxylated Flavones (PMFs)
Citrus fruits are the most important and direct source of Polymethoxylated Flavones (PMFs), which significantly affect consumers’ health.
Experiments on hamsters with high cholesterol show that PMF has particular cholesterol-lowering potential in this kind of hamster. In addition, it is found that PMF can also reduce serum triacylglycerol (blood lipid). PMF is a new flavonoid with the potential of lowering cholesterol and blood lipid.
Nobiletin vs Tangeretin
Both of them, Nobiletin and Tangeretin, are flavonoids that can be isolated from citrus peels. Nobiletin is an O-methylated flavone, almost the same as Tangeretin. However, their molecular structural formulas and functions for our bodies are not the same.
Recent pieces of evidence show that Nobiletin powder is a multifunctional pharmaceutical agent. The various pharmacological activities of Nobiletin include neuroprotection, cardiovascular protection, antimetabolic disorder, anti-cancer, anti-inflammation, and antioxidation.
And what about Tangeretin? Many studies have already shown that it possesses antioxidant and anti-cancer properties.
Tamoxifen is a selective estrogen receptor modulator (SERM) that is usually used to treat all stages of hormone receptor-positive breast cancer, both in women and men. In addition, Tangeretin is an effective tumor growth and invasion inhibitor of human MCF 7/6 breast cancer cells in vitro.
Tamoxifen and Tangeretin flavonoid tangeretin showed similar inhibitory effects on the growth and invasion of human breast cancer cells in vitro. However, when both of them are taken in vivo of our bodies, Tangeretin will neutralize the beneficial tumor inhibitory effect of Tamoxifen and reduce the number of natural killers of tumor cells. So it is suggested that both of them should not be taken orally simultaneously.
Tangeretin has been proved for its anti-cancer effect. However, its bioavailability is not good enough. A derivative of 5- acetoxy -6,7,8,4′- tetramethyl-methoxy flavone was synthesized by acetylation.
This derivative has an exceptionally effective inhibitory effect on the proliferation of human leukemia and breast cancer cells.
In addition, it has been proven in vitro studies that 5-AcTMF has cytotoxicity to MCF-7 cells by inducing intrinsic apoptosis, which indicates that 5-AcTMF has much more potent inhibitory effects on the growth of MCF-7 cancer cells than its parent compound Tangeretin.
TANGERETIN Manufacturing Process
Raw materials used include hot water, citrus fruit, solvent, dilute alkali, and methanol. The simple steps for manufacturing include:
- Treat citrus fruit with hot water to obtain product;
- Dry it to get a dried product;
- Treat it with a solvent that can dissolve Tangeretin to obtain a solution;
- Concentrate and dry Tangeretin solution to get condensate;
- Treat the concentrate with dilute alkali to obtain composition;
- Treat the concentrate by adding Methanol to get Tangeretin pure powder.
Numerous experiments have fully proved the tumor-inhibiting effect of Tangeretin. It has been confirmed that it can inhibit the growth and progress of several cancer cells, such as ovarian cancer, colorectal cancer, gastric cancer, and breast cancer.
Large amounts of animal studies have already indicated that Tangeretin has cholesterol-lowering properties. One of these studies has found that rats fed with diets with Tangeretin showed reduced (nearly up to 40%) serum levels of LDL cholesterol in their bodies.
Recently, some studies have shown that Tangeretin has been proved to have a particular neuroprotective effect, and it can protect dopaminergic nerves from toxins.
Other beneficial effects of Tangeretin against Parkinson’s disease are still under study.
Tangeretin possesses five methoxy groups, respectively, showing various activities, such as anti-cancer, anti-inflammatory, and anti-obesity effects. In addition, previous studies have shown that it can regulate the inflammation and behavior of the central nervous system.
An experiment on OVX mice showed that the femoral bone density of OVX mice lacking estrogen decreased significantly, but after oral administration of PMFs, the bone density of the distal femur in vivo was partially recovered. This also proves that Tangeretin can combat osteoporosis to some extent.
TANGERTIN side effects
Tangeretin is generally considered a very safe compound, and there is no report that it will harm human bodies.
The typical dose of citrus bioflavonoids is 500mg twice a day. And of course, Tangeretin is no exception.
All kinds of specifications are listed:10%,98%,99%.
Cima’s price ranges for bulk quantity for each specification:
- 10%: Fob USD380~425/KG
- 98%: Fob USD9100~9900/KG
- 99%: Fob USD10800~11500/KG
Free sample testing is also provided.
Where to buy TANGERETIN in bulk?
Wuxi Cima Science Co., Ltd is also one of the most well-known manufacturers of Tangeretin in China. For our dear customers, the Tangeretin we produce is of High purity, Complete specifications, and Sufficient stock.
If you want to know about the Tangeretin price and other information, please feel free to contact us, and we will give you a satisfactory reply within 12 hours.
- Zhang M, Zhu S, Yang W, Huang Q, Ho CT. The biological fate and bioefficacy of citrus flavonoids: bioavailability, biotransformation, and delivery systems. Food Funct. 2021;12(8):3307-23. https://pubmed.ncbi.nlm.nih.gov/33735339/
- Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids. J Agric Food Chem. 2012;60(4):877-85. https://pubmed.ncbi.nlm.nih.gov/22224368/
- Hung, W.-L., Chang, W.-S., Lu, W.-C., Wei, G.-J., Wang, Y., Ho, C.-T., & Hwang, L. S. (2018). Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat. In Journal of Food and Drug Analysis (Vol. 26, Issue 2, pp. 849–857). The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA). https://doi.org/10.1016/j.jfda.2017.08.003
- Kurowska, E. M., & Manthey, J. A. (2004). Hypolipidemic Effects and Absorption of Citrus Polymethoxylated Flavones in Hamsters with Diet-Induced Hypercholesterolemia. In Journal of Agricultural and Food Chemistry (Vol. 52, Issue 10, pp. 2879–2886). American Chemical Society (ACS). https://doi.org/10.1021/jf035354z
- Bracke, M. E., Depypere, H. T., Boterberg, T., Van Marck, V. L., Vennekens, K. ’l M., Vanluchene, E., Nuytinck, M., Serreyn, R., & Mareel, M. M. (1999). Influence of Tangeretin on Tamoxifen’s Therapeutic Benefit in Mammary Cancer. In JNCI Journal of the National Cancer Institute (Vol. 91, Issue 4, pp. 354–359). Oxford University Press (OUP). https://doi.org/10.1093/jnci/91.4.354
- Depypere, H. T., Bracke, M. E., Boterberg, T., Mareel, M. M., Nuytinck, M., Vennekens, K., & Serreyn, R. (2000). Inhibition of tamoxifen’s therapeutic benefit by tangeretin in mammary cancer. In European Journal of Cancer (Vol. 36, p. 73). Elsevier BV. https://doi.org/10.1016/s0959-8049(00)00234-3
- Li, Y. R., Li, S., Ho, C.-T., Chang, Y.-H., Tan, K.-T., Chung, T.-W., Wang, B.-Y., Chen, Y.-K., & Lin, C.-C. (2015). Tangeretin derivative, 5-acetyloxy-6,7,8,4′-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. In Cancer Biology & Therapy (Vol. 17, Issue 1, pp. 48–64). Informa UK Limited. https://doi.org/10.1080/15384047.2015.1108491
- Method for manufacturing substance containing nobiletin and tangeretin derived from citrus fruits, and nobiletin- and tangeretin-containing substance obtained thereby https://patents.google.com/patent/EP2907395A1/en
- Zhu, W., Xiao, N., & Liu, X. (2017). Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. In Oncology Letters. Spandidos Publications. https://doi.org/10.3892/ol.2017.7307