Cima Science is a leading manufacturer and bulk supplier of N-Acetylcysteine Ethyl Ester (NACET) powder in China, offering high-purity raw materials for nutraceutical, pharmaceutical, and longevity formulations. We maintain strict quality control to ensure ≥98% purity (HPLC), consistent quality, and dependable global supply.
Cima Science supplies bulk NACET powder at competitive pricing, with customizable specifications and OEM services for supplement brands worldwide. Our products are exported to North America, Europe, and Asia, and are supported by ISO-certified manufacturing and comprehensive quality testing.
We provide free samples, flexible packaging, and fast global shipping to support supplement brands, distributors, and research institutions.
What is N-Acetylcysteine Ethyl Ester?
N-Acetylcysteine Ethyl Ester (NACET) is an advanced derivative of N-Acetyl-L-cysteine (NAC) designed to enhance cellular absorption and bioavailability. The addition of an ethyl ester group increases its lipophilicity, enabling more efficient cell membrane penetration and improved delivery of cysteine for glutathione synthesis, a key intracellular antioxidant. NACET is not found in food sources but is chemically synthesized, which ensures consistent purity and quality for nutraceutical and pharmaceutical use.
N-Acetylcysteine Ethyl Ester, also known as NAC Ethyl Ester or NACET, has CAS No. 59587-09-6. Its molecular formula is C₇H₁₃NO₃S, with a molecular weight of 191.25 g/mol. High-quality NACET is typically supplied at ≥98% purity (HPLC). It is a white crystalline powder, water-soluble, and provides significantly improved bioavailability over standard NAC due to its increased lipophilicity.
For commercial supply, N-Acetylcysteine Ethyl Ester powder is packaged in 25 kg fiber drums with double PE inner bags to maintain stability during storage and transport. Cima Science is a leading bulk supplier in China, exporting over 100 tons annually to nutraceutical and pharmaceutical companies worldwide. The company also provides OEM services, including capsules, tablets, and customized supplement formulations for brands, distributors, and manufacturers.
N-Acetylcysteine Ethyl Ester Powder Specifications
Cima Science provides high-quality N-Acetylcysteine Ethyl Ester (NACET) powder produced under strict quality control to ensure consistent purity, stability, and safety. Each batch undergoes validated analytical testing, including HPLC assays, melting-point verification, and impurity analysis, to meet enterprise quality standards. The product is a white crystalline powder with high purity (98.0–102.0%), low moisture, minimal residual solvents, and tightly controlled heavy metal content. These specifications make NACET powder suitable for nutraceutical, pharmaceutical, and research use. Customized specifications and mesh sizes are available upon request.
| Test Items | Specification | Results |
|---|---|---|
| Description | White Crystalline Powder | White Powder |
| Identification | Positive | Positive |
| Assay (by HPLC) | 98.0~102.0% | 99.34% |
| Absorbance (E1cm) | 465~495 | 482.5 |
| Melting Point | 191~195°C | 193.5~195.0°C |
| Loss On Drying | 0.5% max | 0.19% |
| Specific Rotation | +288° ~ +298° | +290.2° |
| Residue On Ignition | 0.1% max | 0.03% |
| Related Substances (Total) | 1.5% max | <1.3% |
| Related Substances (Single) | 0.5% max | <0.4% |
| Residual Solvents | 0.2% max | 0.10% |
| Heavy Metals | 20 ppm max | <10 ppm |
| Conclusion | The specification conforms with enterprise standard. | |
| Shelf Life | 2 years when properly stored. | |
NAC ethyl ester vs NAC
N-Acetylcysteine Ethyl Ester (NACET) is a modified derivative of N-Acetylcysteine (NAC) developed to achieve superior absorption and enhanced cellular delivery of cysteine. The addition of an ethyl ester group increases lipophilicity, which facilitates more efficient cellular uptake and improved cysteine transport compared to NAC. Research indicates that NACET demonstrates greater bioavailability and provides stronger antioxidant effects at lower dosages.
N-Acetylcysteine (NAC) is extensively utilized and studied, particularly in pharmaceutical and supplement applications, due to its established safety profile, affordability, and widespread availability. While NACET offers increased bioavailability and potency, NAC remains the preferred and more economical option in the supplement industry.
| Parameter | N-Acetylcysteine Ethyl Ester (NACET) | N-Acetylcysteine (NAC) |
|---|---|---|
| CAS Number | 59587-09-6 | 616-91-1 |
| Other Names | NAC Ethyl Ester, NACET | N-Acetyl-L-Cysteine, NAC |
| Molecular Formula | C7H13NO3S | C5H9NO3S |
| Molecular Weight | 191.25 g/mol | 163.19 g/mol |
| Appearance | White crystalline powder | White crystalline powder |
| Food or Botanical Sources | Not naturally occurring; produced by chemical synthesis | Derived from the amino acid L-cysteine found in protein foods such as poultry, eggs, yogurt, and legumes |
| Typical Specifications | ≥98% HPLC | ≥98% HPLC |
| Purity | 98–102% | 98–102% |
| Bioavailability | High; improved membrane permeability and cellular uptake | Moderate; limited cell membrane penetration |
| Potency | Higher intracellular delivery of cysteine and glutathione | Effective but less efficient cellular uptake |
| Typical Dosage (Supplements) | 50–300 mg/day in experimental formulations | 600–1800 mg/day commonly used in supplements |
| Half-Life | Estimated longer intracellular retention | Approximately 5–6 hours |
| Stability | More lipophilic and chemically stable in some formulations | Stable but sensitive to oxidation in solution |
| Popularity | Emerging ingredient in longevity and advanced antioxidant supplements | Highly established ingredient used worldwide in pharmaceuticals and supplements |
| Typical Bulk Pricing Range | Approx. $800 – $3000/kg depending on purity and quantity | Approx. $20 – $80/kg depending on grade and volume |
| Main Benefits | • Enhanced glutathione production • Strong antioxidant potential • Improved cellular uptake • Potential neuroprotective support |
• Supports glutathione synthesis • Antioxidant protection • Liver detox support • Respiratory health support |
| Main Applications | Longevity supplements, antioxidant formulations, advanced nutraceuticals | Dietary supplements, pharmaceuticals, respiratory therapy, liver support |
NACET Benefits
N-Acetylcysteine Ethyl Ester (NACET) is a lipophilic derivative of N-Acetylcysteine (NAC) developed to enhance cellular absorption and antioxidant efficacy. The ethyl ester modification increases membrane permeability and may facilitate crossing of the blood–brain barrier, thereby enabling more efficient intracellular delivery of cysteine. Within cells, NACET is converted to cysteine, which supports glutathione (GSH) synthesis, a critical intracellular antioxidant. Preclinical studies indicate that NACET exhibits greater bioavailability and superior intracellular antioxidant capacity compared to NAC, suggesting potential applications in cellular protection, neuroprotection, and healthy aging. Nevertheless, evidence from large-scale human clinical trials remains limited, and NACET is regarded as a promising next-generation antioxidant for advanced nutraceutical formulations.
- Enhanced Bioavailability: Exhibits greater lipophilicity than N-acetylcysteine (NAC), facilitating improved cell membrane penetration and absorption.
- Boosts Glutathione Production: Provides cysteine directly to cells, supporting glutathione (GSH) synthesis, a critical endogenous antioxidant.
- Antioxidant Protection: Neutralizes free radicals and protects cells from oxidative stress-induced damage.
- Cellular Defense: Enhances intracellular protective mechanisms to promote overall cellular health.
- Neuroprotective Support: Has been investigated for its capacity to cross the blood-brain barrier and protect neurons from oxidative damage.
- Enhanced Stability and Delivery: The ethyl ester structure increases stability and enables more efficient intracellular nutrient delivery compared to traditional NAC.
- Higher Potency at Lower Dose: Increased bioavailability enables smaller doses to achieve equivalent or superior biological effects compared to NAC.
Applications of NACET Powder
N-Acetylcysteine Ethyl Ester (NACET) powder is increasingly recognized as a versatile ingredient in nutraceutical, pharmaceutical, and advanced supplement formulations because of its enhanced antioxidant capacity and improved bioavailability. Its efficient delivery of cysteine for glutathione synthesis renders it valuable for products focused on cellular protection, longevity, and cognitive health.
Dietary Supplements
NACET is increasingly incorporated into dietary supplement formulations because of its strong antioxidant properties and improved cellular absorption. It is commonly included in antioxidant supplements, anti-aging formulations, detoxification support products, and immune health supplements, where it supports glutathione production and protects cells from oxidative stress.
Longevity Ingredients
Within the longevity and anti-aging supplement market, NACET is frequently combined with other advanced ingredients to support cellular health and metabolic function. Typical combinations include Nicotinamide Riboside (NR), NMN, NAD+ precursors, and alpha-lipoic acid, resulting in synergistic formulations intended to promote healthy aging and mitochondrial function.
Pharmaceutical Research
NACET is also under investigation in pharmaceutical and biomedical research because of its enhanced bioavailability compared to traditional N-acetylcysteine (NAC). Current research explores its potential roles in oxidative stress management, cellular protection, and neurological applications, particularly for conditions characterized by increased oxidative damage.
Nootropic Formulation
Certain advanced nootropic formulations incorporate NACET for its potential neuroprotective and antioxidant effects. By supporting intracellular glutathione levels and reducing oxidative stress in neural tissues, NACET may contribute to products targeting cognitive support and brain health.
Manufacturing Process of NACET Powder
The production of N-Acetylcysteine Ethyl Ester powder utilizes a rigorously controlled chemical synthesis process designed to achieve high purity and stability. The process generally comprises the following stages:
- Selection of high-quality raw materials
- Controlled esterification reaction
- Purification and crystallization
- Drying under controlled conditions
- Milling to achieve a standardized particle size
- Comprehensive quality assessment
This production methodology ensures consistent quality, high purity, and batch-to-batch stability. We provide Certificate of Analysis (COA), MSDS, and other technical documentation upon request. Cima Science utilizes secure packaging to preserve product quality throughout storage and transportation. Packaging options include 1 kg and 5 kg aluminum foil bags, and 25 kg fiber drums with double polyethylene inner bags for bulk quantities.
Where to buy Bulk N-Acetylcysteine Ethyl Ester Powder
Cima Science is a manufacturer of high-purity N-Acetylcysteine Ethyl Ester (NACET) powder, offering products at competitive factory prices. As a professional manufacturer of longevity ingredients, Cima Science supplies bulk NACET, NMN, Nicotinamide Riboside, and other NAD+-related compounds to supplement brands, distributors, and research institutions worldwide.
Key advantages of partnering with Cima Science include direct manufacturer supply, competitive wholesale pricing, complimentary samples, ISO-certified production, Halal and Kosher compliance, and expedited global shipping.
For inquiries regarding quotes or complimentary samples of bulk NACET powder, please contact Cima Science immediately. Your inquiry regarding price, COA, MSDS, MOA, flow chart, etc., will be answered in 12 hours.
