What is Ursodeoxycholic acid (UDCA)?
The ursodeoxycholic acid powder is a 99% pure bile acid commonly seen in bears conjugated to taurine. Its chemical name is 3a,7 β-dihydroxy-5 β-Golestan-24-acid. It is an organic compound with an odorless, bitter taste.
BA vs. UDCA vs. TUDCA
Bile acids can be distinguished according to their polarity, as shown in the figure. The upper acronym represents the more hydrophobic bile acids, while the more hydrophilic ones are at the bottom.
Abbreviations:
- CA, cholic acid;
- CDCA, goannedeoxycholic acid;
- DCA, deoxycholic acid;
- GCA, glycolic acid;
- GCDCA, gandeoxycholic acid;
- GDCA, glycodeoxycholic acid;
- LCA, lithic acid;
- TCA, taurocholic acid;
- TCDCA, taurodeoxycholic acid;
- TDCA, taurodeoxycholic acid;
- TUDCA, tauroursodeoxycholic acid;
- UDCA, ursodeoxycholic acid
UDCA Manufacturing Process
The Ursodeoxycholic acid manufacturing process begins with Chenodeoxycholic acid, which is heated with methanol and tartaric acid, and sodium hypochlorite for oxidation. Crystallization takes place via water chromatography and centrifugation before the product is dried to form UDCA oxide. Tert-butanol is used in dissolution with metallic potassium, followed by adding an appropriate amount of water to recover a UDCA-reducing pasty substance fluid. Water and sodium carbonate are next added for dissolution, then hydrochloric acid for acidification and crystallization, followed by centrifugation, which yields a UDCA-reducing substance powder. Acetone is used for dissolution, triethylamine is added as an amine salt, followed by adding water for dissolution; hydrochloric acid is used for crystallization before being centrifuged to yield the final crude product Ursodeoxycholic acid.
UDCA powder Suppliers
Cima Science Co., Ltd., founded in 2010, is a leader in China’s healthcare raw material industry. With over 10 years of experience in UDCA production, our products are renowned for their quality and receive continuous orders from customers worldwide. Our independent R&D team specializes in the fermentation and synthesis of plant extracts and other nutritional chemicals. Welcome to contact us and inquire more about UDCA details.
References
- Kim, B.-T., Kim, K.-M., & Kim, K.-N. (2020). The Effect of Ursodeoxycholic Acid on Small Intestinal Bacterial Overgrowth in Patients with Functional Dyspepsia: A Pilot Randomized Controlled Trial. In Nutrients (Vol. 12, Issue 5, p. 1410). MDPI AG. https://doi.org/10.3390/nu12051410
- Kim, D. J., Yoon, S., Ji, S. C., Yang, J., Kim, Y.-K., Lee, S., Yu, K.-S., Jang, I.-J., Chung, J.-Y., & Cho, J.-Y. (2018). Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction. In Scientific Reports (Vol. 8, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-018-30349-1
- Zhang, Y., Zheng, X., Huang, F., Zhao, A., Ge, K., Zhao, Q., & Jia, W. (2019). Ursodeoxycholic Acid Alters Bile Acid and Fatty Acid Profiles in a Mouse Model of Diet-Induced Obesity. In Frontiers in Pharmacology (Vol. 10). Frontiers Media SA. https://doi.org/10.3389/fphar.2019.00842
- Elfahmi, & Chahyadi, A. (2020). The diversity of ursodeoxycholic acid precursors from bile waste of commercially available fishes, poultry and livestock in Indonesia. In Brazilian Journal of Pharmaceutical Sciences (Vol. 56). FapUNIFESP (SciELO). https://doi.org/10.1590/s2175-979020200001181094
