What is Rhodiola?
Rhodiola Rosea, a perennial herb, belongs to Rhodiola L. family, often having fleshy roots and rhizomes. Rhodiola mainly grows in high cold, dry, hypoxia, intense ultraviolet radiation, and the large temperature difference between day and night, high-altitude regions of Europe and Asia. It has strong environmental adaptability and vitality.
Other names of Rhodiola
Arctic Root, Hongjingtian, Golden Root, King’s Crown, Snowdown Rose, RoseRoot, Siberian Golden Root, Sedum rosea, Siberian Rhodiola Rosea, Extrait de Rhodiole, Lignum Rhodium, Racine d’Or, Orpin Rose Rhodiola Rosea, Rodia Riza, Rose Root Extract Rosewort, Sedum Rhodiola, Racine Dorée, Racine de Rhadiola, Rhodiole, Rhodiole Rougeâtre, Rosenroot, Roseroot, arctic root rhodiola rosea, rhodiola rosea root extract.
Species and distribution of Rhodiola
There are nearly 100 species of Rhodiola around the world, distributed in East Asia, Central Asia, Siberia, and North America. There are 73 species in the China mainland, mainly distributed in the alpine mountains and snow plateau, of which 34 species and 2 varieties are produced in Tibet.
Rhodiola has the functions of tonic, anti-hypoxia, anti-fatigue, improving physical and mental strength, and can also prevent chronic diseases and regulate physical abnormalities. Rhodiola has a long history of the application. More than two thousand years ago, people in Tibet plateau began to use Rhodiola Rosea as medicine to strengthen their health and resist the influence of adverse environments. At present, there are many kinds of Rhodiolas used as medicinal or health products.
Among them, Rhodiola chiefly used for extracting active ingredients are Rhodiola crenulata and
Rhodiola Rosea.
Rhodiola crenulata is generally used as a raw material for Salidroside.
Rhodiola Rosea is the best of Rhodiola series. Only Rhodiola Rosea contains rosavin, rosin and rosarin.
Siberian rhodiola rosea
In Siberia, it is said, “those who drink Rhodiola tea regularly will live more than 100 years.”
Active ingredients of Rhodiola
Rhodiola contains many effective active ingredients, including salidroside, Rosavin, Tryosol, Rosarin, flavonoids, and 14 kinds of amino acid, and various minerals and so on. The components that can be separated from multiple Rhodiola:
1.Phenylpropanoids: rosavin, rosin, rosarin
2.Flavanoids: rodiolin, rodionin, rodiosin, acetylrodalgin, tricin
3.Phenyl ethanol: salidroside, tyrosol
4.Monoterpenoids: rosiridol, rosaridin
5.triterpenes: daucosterol, beta-sitosterol
6.Phenolic acids: chlorogenic, gallic acids
How does Rhodiola extract work?
Salidroside and Rosavin are generally recognized as the main bioactive components used to standardize extraction content.
Salidroside
Salidroside is widely considered as the most important bioactive molecule in Rhodiola. It may be the reason why Rhodiola has protective and stimulative effects on the brain.
Salidroside blocks the production of β amyloid peptide by Inhibition the expression of anoxic inducer -1α and the activity of β-secretase;
Salidroside protects neural cells and nerve stem cells from damage through antioxidant action.
Salidroside can induce neural stem cells and bone marrow mesenchymal stem cells to differentiate into neural cells by intercepting Notch signaling pathway. Salidroside enhances neurogenesis by promoting BMP signaling pathway and PI3K dependent Ca2+ signaling pathway.
Rosavin
Rosavin, also known as the “golden root,” is a chemical extracted from the Rhodiola Rosea Plants. Rosavin is photochemical and is considered to be one of the main components of depression reduction; it has the best effect on mood improvement. Rosavin also has some anti-anxiety effects.
Rhodiola supplements are the best source of rosavin by far. Different proportions of Rosavin extracts can produce different effects.
Rosavin especially helps the body to get rid of excess fat. It can activate hormone-sensitive lipase, an enzyme that can break down fat stored in adipose tissue but is not especially active.
Rosavin does not work alone. When used with other compounds in Rhodiola, such as salidroside, Rosavin can not only increase serotonin production but also reduces cortisol release. Serotonin is a relaxant, while cortisol is a stimulant, so rosavin can effectively reduce tension and anxiety.
Rosavin has many properties and mechanisms similar to salidroside, but a higher dose is needed to produce the same effect.
Benefits of Rhodiola extract
Rhodiola Rosea has been marketed as support for sustained energy, physical performance, and an increased capacity to handle stress and support mood.
Helps Body to Adapt to Stress in Daily Life
Salidroside, like many adaptors, acts on the HPA axis: hypothalamus, pituitary, and adrenal. This glandular system controls many of the body’s stress responses, such as cortisol release. It also affects the expression of Hsp7, a heat shock protein that helps cells adapt to repeated exposure to the same stressors.
Rhodiola extract can significantly increase the body’s oxygen-carrying capacity and the resistance to hypoxia. It helps to improve the aerobic metabolism, decrease the lactic acid content in blood, myocardium, and brain. Thereby Rhodiola extract can quickly regulate the hypoxic environment and delay the generation of fatigue.
Application: Rhodiola extract is an adaptogen: a compound that fights stress by helping the body (especially the brain and immune system) recover to and maintain a healthy balance condition. Rhodiola Rosea anxiety.
Supports Optimal Energy & Mood
In animal experiments, Rhodiola extract, rosavin, and salidroside, showed increased transmission of serotonin precursors, tryptophan and 5-hydroxytryptophan into the brain.
Serotonin is a kind of brain nerve conducting substance which has been widely studied. It has many functions in chemistry. Unstable serotonin is associated with varieties of abnormal mental states, such as clinical depression.
Soviet scientists proved that Rhodiola extract could improve people’s mental state. It becomes a valuable medicine for those who live in countries and seasons where the monthly cycle is prolonged without enough sunshine. (For example, SAD, a seasonal depression, which is more common in northern European countries.)
Promotes Nerve Health and Protects Brain Cell
Rhodiola extracts can protect nerves, promote nerve repair, regulate the release of neurotransmitters in the nervous system, and prevent premature cell death.
Salidroside helps to restore the balance between free radicals and antioxidants, which can protect the brain from poor blood flow and stroke (ischemia). Salidroside activates Nrf2 pathway, protects genes, increases antioxidant proteins, and protects brain cells.
Application: Salidroside may have excellent potential treatment of degenerative nervous system disease.
Antioxidant Effects and Anti-Aging
Rhodiola also reduces and prevents oxidative stress by activating AMPK. Meanwhile, it can also promote the Nrf2 pathway, so that Rhodiola has dual antioxidant capacity.
Many studies have shown that salidroside has an anti-aging effect and can effectively resist diseases caused by aging by limiting the harmful effects of free radicals.
Application: Rhodiola has the functions of whitening, anti-aging, anti-oxidation, and promoting the activity of skin epidermal cells. It has excellent application and development value in daily cosmetics.
Promotes Belly fat burning
The most active compound of Rhodiola, rosavin has an incredible feature: it can help your body burn stored fat more efficiently as a fuel. Rosavin can promote the reduction of visceral white adipose tissue and increase hypothalamic norepinephrine to help prevent diet-induced obesity.
Rhodiola extract helps normalize cortisol levels, so it may also reduce the desire for unhealthy “comfort foods” and delay fat accumulation associated with high cortisol levels (especially abdominal/abdominal fat)
Application: Rhodiola Rosea weight loss; Rhodiola Rosea extract has excellent potential in healthy weight loss.
Are there any interactions with Medications?
Rosavin and Salidroside are highly active molecules that have multiple roles in the body. Therefore, anyone should be careful when supplementing Rhodiola when taking prescription drugs.
Antidepressants
a. Monoamine oxidase inhibitors can’t be taken with any substance that increases norepinephrine or dopamine, without the instruction from your doctor.
b.Selective serotonin reuptake inhibitors may interact with Rhodiola and produce some side effects like gum pain, muscle pain, irregular heartbeat and so on
If you’re taking antidepressants, please do not supplement with Rhodiola without consulting your doctor.
Diabetes drug
Metformin: Rhodiola has some similar effects with metformin; both of them can activate AMPK and then increase the body’s sensitivity to insulin.
Anticoagulants like warfarin
NSAIDs like aspirin, ibuprofen, and naproxen
Hypotensive drugs like losartan
Please confirm with your doctor when you take Rhodiola mixed with the above medicine.
Common Formulas:
- Rhodiola extract and Ashwagandha Formula—- improves the body’s physical and mental response to stress.
- Ashwagandha, Rhodiola extract, and Eleuthero Formula—-boosts mental clarity and provides all-day energy.
- Rhodiola Rosea, Bacopa Monnieri, Ginkgo Biloba Formula— supports good memory, focus, and clarity.
- Ginseng and Rhodiola Herbal Formula—supports healthy lung function and may soothe mild coughing and wheezing.
Dosage and Side effects
Even at a high dose, the potential toxicity of Rhodiola extract is only a quarter of Korean ginseng.
For General health use, the general recommended dose of rosavin in the range of 3.6 to 6.14mg and salidroside around 4.5 mg.
When taken alone for acute use (e.g., for testing or athletic competition). The recommended dose is three times that for long-term use.
Pregnant women and children need a doctor’s medical advice.
Taking more than 800mg of Rhodiola Rosea Extract a day may cause the following side effects: allergies, insomnia, and discomfort.
Where to buy Rhodiola Rosea extract in bulk?
Rhodiola extract market situation: Due to the shortage of Rhodiola raw materials in recent years, the market facts of Rhodiola product adulterated were revealed. According to the survey, about a quarter of the Rhodiola products in the market are either adulterated or low in rosavin, which didn’t conform to their specification sheet regarding the rosavin levels present. Chemical analysis (e.g., HPTLC, HPLC and NMR) is recommended to distinguish high-quality Rhodiola products.
Wuxi Cima Science Co., Ltd is a very professional Rhodiola Rosea extract supplier for many years.
Standardized 3%, extracted from Rhodiola Rosea root-wild, contain Rosavin, Rosin, Rosarin, Salidroside, and all Necessary actives.
General specifications:
- 3% Rosavins & 1% Salidroside;
- 5% Rosavins & 2% Salidroside;
- 1%-10% Salidroside
- 1%-5% Rosavins
You can get expert technical knowledge, and a more comfortable price form us. A free sample for testing is also available.
For American customers, You don’t have to worry about tariffs or customs clearance, as we can keep the stock for you in our CA warehouse.
Just feel free to contact me, if you want to know more information about the price, the certificate of analysis, MSDS and so on.
FAQ
Q: What are the benefits of Rhodiola Rosea compared to ginseng?
Both Panax ginseng and Rhodiola Rosea can help to improve immunity. But the immune effect of Rhodiola extract is stronger than that of ginseng. What’s more valuable is that it is not as dryness-heat as ginseng.
Even at a high dose, the potential toxicity of Rhodiola extract is only a quarter of Korean ginseng.
Q: Which kind of Rhodiola is better for extraction?
Rhodiola crenulata is generally used as a raw material for Salidroside.
Only the Rhodiola Rosea contains rosavin, rosin, and rosarin.
Q: What are the regular specifications of CIMA Rhodiola Rosea root extract?
Salidroside:1%-10%; Rosavin:1%-5%; 3%Salidroside+1%Rosavin; we can also provide some Customized specifications and OEM service.
Q: Rosavin VS Salidroside
Both rosavin and salidroside areare generally recognized as the main bioactive components used to standardize Rhodiola extraction content. Rhodiola owes much to salidroside. It is more active than rosavin. But we cannot completely disregard rosavins, as they work better when combined.
Rosavin has many same properties and mechanisms as salidroside, such as regulate emotion, antifatigue, provide energy, and so on, but rosavin requires a higher dose to produce the same effect.
What’s more, rosavin has incredible effect—promotes the belly fat burning.
