The “NAD world” has become more popular thanks to the many findings and new research available. One of the most known NAD precursors, called NMN (Nicotinamide Mononucleotide), boosts NAD levels in the body effectively compared to the other precursors. Therefore, NMN it’s the most studied NAD supplement when it comes to the benefits of NAD. The recent finding focuses on oral NMN intake and the impact on changes in biomarkers.
The key findings
Based on the findings, there are a few studies done on humans. However, recent research focuses on how NMN improves biomarkers in humans. Improving biomarkers can lead to better anti-aging effects and healthy life extension.
For this case, 17 postmenopausal women, between 50 and 80 years old, without previous diseases, undergo the study. In the final study, 16 participants continued the investigation because one participant dropped out due to a mild headache. They were given 300 mg/day ( 2 capsules with 150 mg NMN) of oral and pure NMN for eight weeks. The capsules were taken after breakfast, and certain parameters were measured at three points, at zero weeks (the morning before breakfast), after four, and after eight weeks. During the study, the participants were not allowed to change any smoking, drinking, or exercising habits. They were only allowed to drink water 12 hours before the test. During the investigation, parameters like BMI, weight, height, blood analysis, and skin analysis were measured at zero weeks, after four, and after eight weeks.
NMN improves skin, hormones, and metabolic health
After eight weeks, there were changes in the HbA1C levels. High HbA1C indicates high blood sugar. In this study, the HbA1C levels were reduced, which improves glucose metabolism. In addition, NMN increases HDL-C (high-density lipoprotein cholesterol). High levels of HDL-C indicate better metabolism.
Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research. June, 2022.
(The changes in HbA1C and HDL.)
Furthermore, the researchers investigate how NMN supplementation impacts the hormonal balance in women. They analyze DHEA-s, which is also called the “mother hormone precursor” sex hormone. After eight weeks, NMN supplementation increases DHEA-s levels in the blood, which indicates improved women’s health.
Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research. June, 2022.
(The changes in DHEA-s, the mother hormone.)
The evaluation of six parameters, including the evaluation of dry skin, moisture, tension, make-up, blemishes, and rough skin, was significantly decreased. Only in the evaluation of eruptions were found no changes. After eight weeks, changes were also observed in the AF (autofluorescence) value. By measuring advanced glycation end products (AGEs) with AF in the skin of the women who participated, NMN presented a decrease in AGEs. Increased AGEs levels are linked to age-related skin changes, and that’s why NMN impacts AGEs reduction and has positive skin benefits.
Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research. June, 2022.
(Improvements in the skin, after eight weeks of NMN supplementation.)
There were no significant changes in the SIRT1 mRNA expression regarding the amount of NAM, NMN, and NAD in the blood.
Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research. June, 2022.
(No changes in the SIRT1 mRNA expression.)
The main points
All these measurements after eight weeks prove that NMN can improve the skin (skin moisturizing, fine lines, dark spots, freckles, whitening the skin, etc.), the sleep (easier falling asleep, better waking up, better sleep quality), and improve physical activity and fatigue (better mobility, less fatigue, better recovery after exercising, etc.).
Other improvements were observed, such as less eye strain, less weight gain, better night vision, enhanced constipation, better mood, faster hair growth, less joint pain, better thinking, and more.
Among the other findings done in humans, there were other NAD+ precursors used to boost NAD+ levels. Clinical studies in humans were done by taking NR (Nicotinamide riboside). NR is another NAD precursor converted to NAD via NMN first. However, the results showed no improvements in the parameters and no anti-aging effect. NR didn’t show any positive anti-aging effects. This can be due to NR’s slow and reduced absorption, which weakened the effects.
Many studies have proven the benefits of NMN supplementation in humans. For example, in one study NMN group and the placebo group were given different amounts of NMN. The results show a dose-dependent increase in using oxygen in the skeletal muscle but no other changes in BMI, body fat percentage, and more. This study indicates that consuming NMN can improve endurance in athletes. Another study showed that NMN improves lower limb function when given in the afternoon and also reduces sleepiness in the elderly, which contributes to better mental and physical health.
These studies also show different organ sensitivity to NMN supplementation in humans, effects on sleep quality, physical endurance, fatigue, long-term usage, safety, and intake timing.
Limitations in the study
There were certain limitations in this study. Initially, NMN was taken only once during the day, after breakfast. SIRT1 mRNA is also rapidly degraded to replenish the NAD levels, and the timing could affect the measurements.
Conclusion
With the latest study in mind, nowadays, NMN can help in practical medicine to improve biomarkers including lipid metabolism, glucose metabolism, immunity, hormone disbalances, and blood parameters in biochemistry used as clinical tests. The positive changes of certain biomarkers suggest that NMN can be effectively and safely used as a supplement for prolonging lifespan and improving anti-aging effects.
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Reference:
- Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research. June, 2022.
