The latest NMN study finds that NMN Combination with Resveratrol or Ginsenosides boosts NAD levels by almost twice in the human body. NAD+ is essential for creating energy in the body and regulating key cellular processes. NAD+, with the full name nicotinamide adenine dinucleotide, is a coenzyme found in every body cell and engages in hundreds of metabolic processes. But NAD+ levels decline with age. Recently, it has been a valued molecule in scientific research due to its central role in biological functions. Scientists are exploring how NAD+ contributes to benefits in mice, inspiring researchers to continue investigating these findings in humans. In addition, recent studies found that combining NMN powder, the most effective NAD+ precursor, combined with another compound can boost NAD+ levels much better.
What is resveratrol?
Resveratrol powder is a powerful antioxidant that has antibacterial and anti-inflammatory properties. It has a beneficial effect on overall health. Resveratrol is a polyphenol, a substance that acts similar to antioxidants because it protects the cells from damage and oxidation. It helps dilate blood vessels as it increases the production of nitric oxide. This relaxes blood vessels, reduces bad cholesterol levels, and lowers blood pressure. Resveratrol was discovered to reduce the formation of parts of the so-called beta-amyloid. Beta amyloids build up in the brain, it leads to Alzheimer’s disease. Resveratrol helps with other neurodegenerative conditions, helps fight cancer, relieves joint pain, controls diabetes, and more.
Other terms referring to resveratrol are Trans-3,4,5-TRIHYDROXYSTILBENE trans-3,5,4′-STILBENETRIOL, 5′-trihidroksi-TRANS-stilbena, and more. The CAS number of resveratrol is 501-36-0. It has a molecular formula of C14H12O3 with a molecular weight of 228.24 g·mol−1. It appears as a white powder with
slight yellow cast, which is insoluble in water.
What are ginsenosides?
Ginseng, also known as God’s grass, goblin, etc., is a perennial plant. Ginseng mainly contains saponins, polysaccharides, polypeptides, glycosides, and flavonoids. The fleshy root of ginseng has been of great value in beauty, medicine, and clinical application since ancient times. Ginsenosides are the main active pharmacological components of ginseng. Ginsenosides, also known as steroid-like saponins, are unique to ginseng species. It is used as an aphrodisiac and is recommended for people exposed to intellectual and great physical efforts, people over 40 years old, people exhausted by illness, and everyone who wants to improve their quality of life. Ginseng is used in various diseases caused by high blood pressure, menopause, or a weakened immune system. Research has shown that ginseng can positively affect the immune system, thus reducing colds in adults. Ginseng is also believed to lower blood sugar levels and improve concentration.
The ginsenosides powder has the potential to fight the aging process. It can regulate nicotinamide phosphoribosyltransferase (NAMPT), which is important for mitochondrial health and function. NAMPT plays an important role in the salvage synthesis pathway of NAD+, which helps to increase the level of NMN in the body.
Ginsenosides are also known as 20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside. It has a CAS number of 41753-43-9 with a molecular weight of 1109.3 g·mol−1 and a molecular formula of C54H92O23. It appears as a light yellowish to a fine brown powder highly soluble in water.
The latest finding
NMN can be combined with other compounds to effectively boost the NAD+ levels in the body. This study combined 500 mg/kg oral NMN with 50 mg/kg ginsenosides Rg3&Rh2 or 50 mg/kg resveratrol to investigate the NAD+ levels in different tissues. The dosage was given to mice that fasted overnight at 6–8 weeks of age. The mice were divided into four groups: the control group, the NMN alone group, the NMN combined with ginsenosides Rg3&Rh2, and the resveratrol. The brain, heart, kidney, liver, lung, and muscle were collected as tissue samples. The results were observed after 1, 2, 4, and 6 hours of administration.
The combination of NMN with resveratrol or ginsenosides significantly increased NAD+ levels in different tissues. When given NMN alone, NAD+ was raised in the liver and kidney. The combination of NMN and resveratrol increased NAD+ levels in the skeletal muscle and the heart by 1.72-fold and 1.59-fold, respectively, six hours after oral administration. NAD+ abundance in the muscle and heart can protect the muscle from damage, fibrosis, inflammation, and other conditions. When NMN was combined with ginsenosides Rg3&Rh2, the NAD++ level in lung tissue was increased by 1.97 times. This finding suggests that NMN, together with ginsenosides Rg3&Rh2 or resveratrol, can treat age-related diseases.
Bai LB, Yau LF, Tong TT, Chan WH, Zhang W, Jiang ZH. Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022 Aug;10(4):e00986. DOI: 10.1002/prp2.986. PMID: 35844164; PMCID: PMC9289528.
(NMN in different tissues in mice compared to the control group and oral administration of NMN, NMN + R, and NMN + G for 1, 2, 4, and 6 h, respectively.)
Bai LB, Yau LF, Tong TT, Chan WH, Zhang W, Jiang ZH. Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022 Aug;10(4):e00986. DOI: 10.1002/prp2.986. PMID: 35844164; PMCID: PMC9289528.
(Effect of NMN together with other compounds in boosting NAD+ levels.)
This finding suggests that oral NMN administration with resveratrol and ginsenosides Rg3&Rh2 could give better results in rising NAD+ levels when compared to NMN alone. This is an important factor in the aging process, apoptosis, and cell growth.
Limitations in the study
Although this study is the first to investigate the distribution of NMN and NAD+ levels in different tissues when combined with other molecules like resveratrol and ginsenosides Rg3&Rh2, some limitations were found. Initially, the samples used for the study were very small (20–25 g), which could affect the statistical evaluation. Furthermore, only adult mice were present as samples. Further investigation is needed to determine the NMN and NAD+ distribution in tissues in mice of different ages and sizes.
To sum up
NMN exerts its effects much better in correlation with other molecules than acting alone. NMN acts synergistically with resveratrol and ginsenosides Rg3&Rh2. When combined NMN with resveratrol, they increased the NAD+ levels in the skeletal muscles and heart, while when combined with ginsenosides Rg3&Rh2, they increase the NAD+ levels in the lungs. With these compounds present, the distribution of NMN is improved in specific tissues. That’s why this study can help to use NMN as a combination treatment for increasing NAD+ levels in different health conditions.
As David Sinclair said: combining NMN and resveratrol could only do more with less.
References:
- Bai, L., Yau, L., Tong, T., Chan, W., Zhang, W., & Jiang, Z. (2022). Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. In Pharmacology Research & Perspectives (Vol. 10, Issue 4). Wiley. https://doi.org/10.1002/prp2.986
