What is Piperlongumine?
Piperlongumine powder is a natural active ingredient in the fruits and roots of Piper longum L. plant.
According to Wikipedia, the IUPAC name of piperlongumine is 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one, and some websites prefer to use 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone.
The full chemical name of piperlongumine is so long and no people can remember it, so researchers use piplartine or piperlongumine in most scientific documents. And 20069-09-4 is its CAS registered number.
Botanical sources of Piperlongumine
Piperlongumine is mainly found in Piper longum, a plant belonging of South Asian origin. India and China are the two main countries that sell commercial Piper longum powders and supplements on Amazon and other e-commerce websites.
Piper longum is commonly known as long pepper or pippali in India. Piper longum contains alkaloids, amides, Lignans, Esters, volatile oils, etc.
Chemical constituents of the Piper Longum plant
The primary active ingredients isolated from Piper longum include piperine, piperlongumine, sylvatin, sesamin, diaeudesmin piperlonguminine, pipermonaline, and piperundecalidine. Below are some chemical components reported to be part of piper longum:
There is no bulk piperlongumine powder on the market yet. Most suppliers are reagent companies, and their products are for research use only. In addition, their quantity is usually only 10 to 500mg in a very small bottle.
There are ratio extracts of the piper longum plant, with popular specifications such as 4:1, 10:1, 20:1, etc.
Indian herbal products containing piperlongumine are mainly ratio extract. How many piperlongumines are in it? Nobody knows. Only standardized piperlongumine from piper longumine can be measured.
Cima’s specification is 98% min.
If you have any inquiries, please don’t hesitate to contact us for more details.
Piperlongumine is not soluble in water. So, if you want to use piperlongumine supplements, you need to make piperlongumine in the form of capsules instead of piperlongumine tablets or powders.
Piperlongumine is soluble in organic solvents such as ethanol, DMSO, and dimethylformamide (DMF).
Mechanism of Action of Piperlongumine
How piperlongumine works is complicated. The flow chart below is just a brief illustration:
Where to buy Piperlongumine powder?
Currently, there is no standardized piperlongumine elsewhere.
Cima Science is the first company to customize bulk piperlongumine powder 98% and 99% in large quantities. If you want to know the pricing and technical documents such as COA, MSDS, or any other certificates, feel free to let us know.