What is Diosgenin?

Diosgenin is an important basic raw material for steroidal hormone drugs. 60% of steroid hormone drugs in the world are based on diosgenin. The main sources of diosgenin were Dioscorea zingiberensis (yellow ginger) and Dioscorea zingiberensis (white ginger). As a raw material for the synthesis of steroid hormone intermediates and steroid hormone drugs, diosgenin is commonly used to produce dienone acetate (diene for short), progesterone (progesterone), cortisone series, oxytocin, pregnancy drugs, and cosmetic products.

Known as the “medicinal gold” in the medical industry, diosgenin has been selling well in more than 120 countries and regions such as Europe and America.

Diosgenin structure

Product Name Bulk Diosgenin powder 98%
Synonyms (20R,25R)-spirost-5-en-3-beta-ol; Nitogenin; (8xi,9xi,10xi,13xi,14xi,16xi,17xi,25R)-spirost-5-en-3-ol; (3beta,25R)-spirost-5-en-3-ol; spirost-5-en-3-ol; (3beta,8xi,9xi,14xi,16xi,17xi,25R)-spirost-5-en-3-ol;

Wild Yam Root Extract

CAS number 512-04-9
Molecular Formula C27H42O3
Molecular Weight 414.63
Appearance White to yellowish flaky or acicular crystals
Benefits Anti-infection, anti-allergic, anti-viral, anti-shock,
Dosage 16mg to 20mg
Bulk Package 20kg/bag

Diosgenin forms and specifications

  • Diosgenin powder: 10%, 16%, 98% 99%
  • Shipment: By Courier like FedEx, UPS, by air, by sea
  • Package: 20kg/bag (Waterproof plastic bag)

6-keto diosgenin VS diosgenin

Diosgenin is extracted from Dioscorea zingiberensis by hydrolysis. 6-keto-diosgenin is a plant-based steroid that can be extracted from Smilax sieboldii and certain Dioscorea species and can be synthesized from diosgenin. The property blend of Ananbol hardcore anabolic activator includes the 6-keto-diosgenin ingredients such as 6-Keto-Diosgenin Acetate, 6-Keto-Diosgenin Propionate, 6-Keto-Diosgenin Cypionate, 6-Keto-Diosgenin Decanoate, and hecogenin acetate. Due to the complicated purifying process to identify the active ingredients, it takes 2000 lbs of raw Dioscorea to make just 40 lbs of Diosterol.

Diosgenin and DHEA

The full name of DHEA is dehydroepiandrosterone. Also known as androstenolone, DHEA is a natural precursor to steroid hormones.

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosteron DHEA chemical structure

Synonyms: Prasterone; Androstenolone; Dehydroisoandrosterone;trans-Dehydroandrosterone; Hydroxyandrost-5-en-17-one
Appearance: White or yellowish-like crystals
Molecular formula: C19H28O2
Molecular weight:288.43

DHEA, a derivative of diosgenin, is used as an intermediate in the manufacture of steroidal hormone drugs, and has anti-aging and protein assimilation effects.

As a multidirectional “hormone buffer”, DHEA can regulate the hormone secretion in women, balance the levels of androgens and estrogens in the body, improve the ovarian microenvironment of infertile women, make their function younger, and then improve the quality of ovum and embryos. Among various infertility factors, ovulation disorder in the woman accounts for 25%. DHEA can induce ovulation and improve the success rate of conception.

The effect of DHEA is not limited to the steroid hormone precursor but also can improve the negative mood and cognitive dysfunction of perimenopausal women, such as depression. Meanwhile, DHEA can regulate and stabilize the body’s immunity; increase bone density and prevent osteoporosis; resist bacteria and viruses; stimulate the proliferation of vascular endothelial cells. It also has a protective effect on cardiovascular disease.

Main functions of DHEA:

  • Delay aging and maintain youthful vitality;
  • Improves physical performance, mood, sleep, and memory;
  • Improve sexual function and libido;
  • Regulate the function of the immune system and improve the body immunity;
  • Weight loss;

How does diosgenin work?

Steroid hormone intermediates and a variety of steroid hormone drugs can be synthesized from diosgenin.

So, what are steroid drugs?

Steroid hormone drugs refer to the hormone drugs with steroid structure in the molecular structure, which has very important medical value. It has a definite role in maintaining life, regulating sexual function and birth control.

The main mechanisms of action of this drug are as follows:

1.Immunosuppression: It can inhibit the synthesis of acetylcholine receptor

antibodies so that the acetylcholine receptors in the postsynaptic membrane of the nerve-muscle junction are protected or less vulnerable to damage caused by autoimmune attack. It also inhibits antibodies to other components of skeletal muscle.

2.Facilitation effect: It makes it easier for the presynaptic membrane to release acetylcholine, making the excitation easier to transmit.

3.Regeneration: The endplate was regenerated, and the number of acetylcholine receptors in the postsynaptic membrane was multiplied.

Synthesis of progesterone from diosgenin

Progesterone, also known as progesterone, is natural progesterone secreted by the corpus luteum of the ovary, also known as progesterone, is necessary for the maintenance of pregnancy. It plays an important role in uterine endocrine transformation, decidualization, maintenance cycle, and pregnancy maintenance.

Progesterone is divided into progestin and 19- normotropin.

1.Progestin: Progestin is a kind of progesterone, which is obtained by hydrolysis and oxidation of dienol ketone acetate (diene) converted from ginger saponin.

Progesterone can and enzyme reaction and failure, and water can also occur reaction, so more difficult medication. Therefore, different substituents need to be introduced. Such as the synthesis of progesterone acetate and progesterone aproate.

When R is methyl, it is progesterone acetate, an oral progestin hormone. Thus can synthesize angoprogesterone, megesterone, hydrocortisone and dozens of steroid progesterone drugs and corticosteroid drugs. When R is n-amyl, it is progesterone aproate, which can be used to prevent and treat abortion, irregular menstruation, functional uterine bleeding, endometriosis, endometrial cancer, breast cancer, chronic prostatic hypertrophy, etc.

Diosgenin Benefits

Support women’s health(menopause)

The estrogen-like compounds in wild yam may help ease menopausal symptoms. A double-blind placebo-controlled trial of 13 peri- and post-menopausal women in 1997 found that those taking wild yam combined with other herbs experienced a reduction in the number and severity of menopausal symptoms such as hot flushes, mood changes, and insomnia.

Help Hormone production and imbalance

The diosgenin compound mimics human estrogens and androgens to be just as effective as many hormonal drugs without the risks. Hormone production in our bodies is dramatically decreased as we grow older, causing hormone imbalances that have a profound effect on an individual’s physiological and emotional wellbeing.

Help soothe occasional gastrointestinal discomfort

The gastrointestinal upset could be allergic. Diosgenin has a strong anti-allergic effect in vivo, which can enhance intestinal T cell immunity, inhibit the intestinal allergic reaction, and reduce the occurrence of diarrhea.

Diosgenin breast enlargement

Diosgenin can stimulate the growth of breast tissue, to achieve the effect of breast enlargement. The female absorbs more, still can adjust the metabolism inside the body, beautify curve, can keep good tall and straight sex especially, avoid bosom droop.

Diosgenin side effects

No serious side effects have been reported yet. Diosgenin is regarded as safe when taking properly. However, long-term use may induce or aggravate the infection.

Diosgenin dosage

As with most organic supplements, there are no dosage guidelines for diosgenin. However, the dose for wild yam extract is 1000mg. The standard purity of diosgenin in wild yam is 16%. So 160mg of diosgenin is a good start. However, it’s best to consult a health professional before adding any diosgenin-containing supplements to your routine.

Diosgenin price

If you are interested in purchasing bulk diosgenin powder, please kindly send us an email. Your inquiry regarding price, COA, MSDS, MOA, flow chart, etc. will be answered upon 12 hours.

Where to buy bulk Diosgenin powder

Cima Science is a professional manufacturer and supplier of diosgenin powder in large quantities. If you are trying diosgenin powder in your supplement formula and want to know the price of diosgenin, and where to buy diosgenin powder in large quantities, you come to the right place.

The specifications of Cima diosgenin is 98% min, all high quality guaranteed at a good price.


Q: how to get the body to break down diosgenin?

A: Diosgenin is metabolized mainly in the liver. The steroid hormones synthesized by diosgenin can enter the target cell through the carrier, and then bind with the receptor to form a complex, which has the ability to pass through the nuclear membrane. Most of the degradation products of steroid hormones are filtered out through the glomerulus or excreted into the urine through the renal tubules.

Q: how to make diosgenin bioavailable?

A: Thousands of steroid hormone drugs can be synthesized from diosgenin, such as dienone acetate (diene), progesterone (progesterone), dehydroepiandrosterone, progesterone acetate (single ester), dididiasone, cortisone series, oxytocin, pregnancy drugs, and cosmetic products, etc.

Q: bio-identical phyto-diosgenin for men

A: Biohomogeneous hormones are estrogens based on plant diosgenin.It is an effective and natural option for restoring and balancing hormone levels in men.

Men who have been treated with bioidentical hormone therapy report benefits such as:

  • More energy
  • Reduced body fat
  • Improved mood
  • Reduced anxiety
  • Increased muscular strength
  • Boosted sexual performance
  • Maintenance of lean body mass

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