What is Urolithin B?
Urolithin B, derived from pomegranate peels, is a phenolic compound found in the human gut after absorption of ellagitannins-containing foods such as pomegranate extract, strawberries, walnuts, or oak-aged red wine.
Urolithin B VS Urolithin A
Both Urolithin B and Urolithin A powder are used in supplements, but with different functional benefits. They work with a different mechanism of action. Urolithin A is mainly for the Anti-aging formula for its mitophagy mechanism while urolithin B is in sports nutrition formula as a muscle-building ingredient.
Urolithin A is a much more well-researched compound, it has been generally regarded as safe (GRAS) by the FDA, while urolithin B is not. There are more supplement brands using urolithin A than urolithin B.
Urolithin A and Urolithin B are closed related. Pomegranate extract contains both of these urolithins. Pomegranates are the zenith of fruit. After digestion, their constituent parts can be converted by gut flora into urolithin C and then further transformed into Urolithin D and A, and then Urolithin B. In this sense, urolithin A can be converted to urolithin B.
Consequently, small amounts of urolithin B can be found in the blood of individuals fed with pomegranate extract; however, its antioxidant and anti-inflammatory properties are much weaker than urolithins A.
However, urolithin B has its own advantage over urolithin A. It’s able to increase muscle cell size and accelerate muscle growth.
Food sources of Urolithin B
Urolithin B is the metabolite of ellagic acid or ellagitannins (punicalagins). Pomegranates are packed full of ellagic acid, which is one form of a class called tannins. Urolithin b can be found in many fruits and nuts including pomegranate peels and seeds, some berries like raspberries or strawberries as well as grapes from muscadines to oak-aged wines, although the urolithin b content in ellagic acid is low. It’s important that you know about the history behind these molecules because they may do wonders for your health! Urolithin B is also a natural bioactive present in shilajit extract, also known as asphaltum. Shilajit is a traditional ayurvedic medicine used as an aphrodisiac.
How does Urolithin B work?
Reports have shown urolithin B can activate AMPK to increase fat burning and energy expenditure while inhibiting inflammation and oxidative stress.
Urolithin B has been shown to boost protein synthesis and inhibit the ubiquitination-proteasome pathway, which leads to better growth of C2C12 myotubes. Further genetic testing reveals that this occurs via an interaction with the androgen receptor
The details about how urolithin B interacts with AMPK are unknown but it seems like there may be some sort of crosstalk happening between our old friend mTOR (mammalian target of rapamycin) in conjunction with its close associate AMPK.
Urolithin B benefits
Urolithin B was found to inhibit protein catabolism, while simultaneously boosting muscle growth. This natural ingredient has been shown in research studies to help build lean muscle and prevent its breakdown.
Urolithin B as Muscle Builder for muscle growth
Urolithin B holds tremendous promise to increase skeletal muscle mass. Clinical research on Urolithin B in mice found that it enhanced myotubes’ growth and differentiation by increasing protein synthesis, a process of building cells from amino acids.
Unlike other supplements which have only shown beneficial effects for weight loss but not necessarily increased muscle mass, urolithin b showed an ability to inhibit the ubiquitination pathway (UPP), the principal mechanism for protein catabolism- or breaking down of proteins into smaller units so they can be eliminated faster.
Urolithin B supplements available
One typical urolithin B supplement is Ep1logue by Olympus Labs. Ep1logue is a natural formulation that helps build lean muscle while preventing muscle breakdown. Urolithin B is one of the most powerful natural muscle builders available that can increase protein synthesis for max muscle building & recovery.
“Urobolin” is the trademarked ingredient in 99% pure urolithin B extracted from punica granatum, better known as pomegranate. It’s a muscle builder that also works to reduce your body’s breakdown of muscles too!
Epicatechin as PhytoFUSE is for giving you the energy to get through a difficult workout and recover quickly. Gallate-Enhanced Oligomers as Vaso6 will help your muscles feel more pumped during intense training sessions, so go ahead and push yourself!
Urolithin B Dosage
There is no recommended dose for urolithin supplement for the time being. There are no stand-alone urolithin B supplements. Urolithin B is often formulated with other bodybuilding compounds, such as epicatechin and phosphatidylcholine. 300mg urolithin B capsule a day is a popular start.
Urolithin B side effects
No adverse effects have been reported yet. Urolithin A, its derivatives in the urolithins category, is generally regarded as safe (GRAS) by the FDA and has no known side-effects to date. More clinical trials on Urolithin B should be done in the future for a more thorough evaluation of safety parameters that are not currently available due to a lack of studies being conducted at this time.
Where to buy Urolithin B bulk powder
With two manufacturing factories of its own based in Shandong province and Wuxi city of Jiangsu province, Wuxi Cima Science Co., Ltd is the leading manufacturer and supplier of natural ingredients. Pure urolithin B powder and bulk urolithin A powder are both available. If you want to buy Urolithin B powder with purity up to 99%, please don’t hesitate to leave a message below to get a quote immediately. Technical documents such as certificate of analysis (COA), MSDS (Material Safety Data Sheet), specification sheet, Method of Analysis (MOA), etc. are obtainable upon your specific request.