What is D-(−)-Pantolactone?

D-(−)-Pantolactone is a degraded product of pantothenic acid, which is an essential vitamin that is water-soluble.

D-(−)-Pantolactone structure

Product Name D-(−)-Pantolactone powder
Other names Pro-vitamin B5; 2(3H)-Furanone; (R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone; D-(-)-2-Hydroxy-3,3-dimethyl-γ-butyrolactone; D-(-)-Pantoyl Lactone; Pantothenic Lactone; α-hydroxy-β,β-dimethyl-γ-butyrolactone; (3R)-dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
CAS Number 599-04-2
Molecular Formula C6H10O3
Molecular Weight 130.14
Specifications >98.0%
Appearance White Crystalline Powder
Usage Intermediate for the synthesis of pantothenic acid,
Bulk Package 25kg/drum

The unique CAS Registry Number of D-(−)-Pantolactone is 599-04-2, with C6H10O3 as its molecular formula. It has many other names, such as α-hydroxy-β,β-dimethyl-γ-butyrolactone, Pantothenic Lactone, and its IUPAC Name is (3R)-dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone.

D-(−)-Pantolactone is hygroscopic and obtained by benzene/petroleum ether or sublimation. Its melting point is 80 (92°C), boiling point 130°C/2.4kPa, soluble in water, ethanol, ether, chloroform, carbon disulfide, benzene. r-type melting point is at 92°C, [α]-50.7° (C=2.05, H2O), s-type melting point is at 91°C, [α]+50° (C=2.00, H2O).

Manufacturing Process

D-(−)-Pantolactone is produced by condensation of isobutyraldehyde with formaldehyde to produce α,α-dimethyl-β-hydroxypropionaldehyde, which is further condensed and hydrolyzed, acidified and lactonized with the participation of calcium chloride.

D-(−)-Pantolactone Uses

It is used in the synthesis of calcium D-pantothenate, D-panthenol, Vitamin B5, or as other pharmaceutical intermediates.

Where to buy D-(−)-Pantolactone in bulk?

Cima Science is a professional manufacturer of D-(−)-Pantolactone powder in China. If you want to buy D-(−)-Pantolactone in large quantity, please send an inquiry to us to get the best quotation within 8 hours.

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