What is Pro-xylane?
Pro-xylane, also known as hydroxyethyl tetrahydropyrantriol, Proxylane, Puri-Xylane, or Pro xylane, is a biomimetic sugar-derived anti-aging ingredient widely used in high-performance skincare formulations. It is not extracted from a botanical or food source but is produced through advanced green chemistry from xylose, a natural sugar found in wood and plant cell walls. Pro-xylane supports glycosaminoglycan (GAG) synthesis, enhances skin density, improves elasticity, and boosts hydration, making it a premium active for firming and moisturizing products. It has the CAS number 439685-79-7, a molecular formula of C8H16O5, and a molecular weight of 192.21. Cima Science is the leading manufacturer of bulk Pro-xylane powder in China, offering both industrial-scale production and a stable, year-round global supply.
Commercial Pro-xylane is available as a 99% HPLC-pure powder or as a liquid solution in various concentrations, making it easier to formulate. The powder form appears as a white crystalline powder, while the solution is clear to slightly yellow. It is water-soluble, has excellent skin bioavailability due to its small molecular structure, and remains stable across a wide pH range, making it ideal for serums, creams, ampoules, and premium skincare lines. Standard bulk packaging is 25 kg per drum, with custom packaging available. As a manufacturer and OEM provider, Cima Science also supports custom Pro-xylane formulations, including capsules, tablets, liquid solutions, and private-label contract manufacturing for cosmetic and nutraceutical brands.
Pro-xylane vs Retinol
Pro-xylane and Retinol are both popular anti-aging actives, but they work in very different ways. Pro-xylane is gentler, highly stable, deeply hydrating, and supports skin firmness by boosting glycosaminoglycans (GAGs). It is well tolerated by almost all skin types, including sensitive skin. Retinol, on the other hand, is one of the strongest collagen-boosting actives but is less stable, more irritating, and requires careful formulation to prevent degradation.
- Pro-xylane is better for hydration, firmness, sensitive skin, long-term stability, and premium anti-aging formulations.
- Retinol is better for wrinkle reduction, cell turnover, pigmentation, and strong anti-aging effects, but with more irritation risk.
| Item | Pro-xylane | Retinol |
|---|---|---|
| CAS Number | 439685-79-7 | 68-26-8 |
| Other Names | Hydroxyethyl tetrahydropyrantriol, Proxylane, Puri-Xylane, Pro xylane | Vitamin A, All-trans-retinol |
| Molecular Formula | C8H16O5 | C20H30O |
| Molecular Weight | 192.21 g/mol | 286.46 g/mol |
| Appearance | White crystalline powder or clear liquid | Yellow to orange crystalline powder or viscous oil |
| Food/Botanical Sources | Synthetic from xylose (no direct food source) | Animal liver, dairy, eggs; synthetic versions used in cosmetics |
| Specifications | 99% HPLC powder, or 10–30% liquid solution | 98% purified retinol, encapsulated retinol, retinol 0.1–1% serums |
| Purity | Up to 99% | Typically 98%+ for raw material |
| Solubility | Water soluble | Oil soluble |
| Bioavailability | High, excellent dermal penetration | Moderate, depends heavily on stabilization and delivery systems |
| Potency | Strong hydration, firmness, dermal support | Strong collagen boosting, anti-wrinkle, cell turnover |
| Typical Dosage | 1–5% in final formula | 0.1–1% in cosmetics |
| Half-life | Long stability in formulations | Short, degrades quickly with heat, oxygen, light |
| Stability | Very stable under heat, pH, and light | Highly unstable; requires encapsulation or antioxidants |
| Skin Irritation | Very low, suitable for sensitive skin | High irritation potential (peeling, redness) |
| Popularity | Increasing in luxury anti-aging skincare | Extremely popular worldwide across all skincare tiers |
| Pricing (General Market Range) | Medium to high (premium active) | Low to high (varies by purity and encapsulation form) |
| Main Benefits | Boosts GAGs, firmness, density, hydration, elasticity | Reduces wrinkles, increases cell turnover, fades dark spots |
| Mechanism of Action | Stimulates GAG synthesis, strengthens dermal matrix | Converts to retinoic acid to increase collagen production |
| Best For | Sensitive skin, hydration, firming, premium serums | Anti-wrinkle, acne care, pigmentation correction |
| Formulation Difficulty | Easy to incorporate | Difficult due to instability and irritation control |
| Compatibility | Works with peptides, HA, vitamin C, most actives | Incompatible with strong acids, requires careful pairing |
Pro-xylane Specifications
Wuxi Cima Science Co., Ltd. supplies high-purity Pro-xylane Powder 99% and customized Pro-xylane Liquid solutions 10%, 20%, 30% for cosmetic manufacturers, skincare brands, and OEM/ODM formulation labs. The power is packed in 1 kg aluminum foil bags, 5 kg aluminum bags, or 25 kg fiber drums with double-layer inner liners, while liquid proxylane is available in 1 kg, 5 kg, or 25 kg drums, or custom packaging for OEM projects. Both forms are produced under strict GMP and ISO standards to ensure consistent quality, stability, and performance in anti-aging and firming skincare applications.
Pro-xylane Manufacturing Process
Cima Science produces high-purity Pro-xylane Powder 99% using a controlled, multi-step manufacturing process based on green chemistry and advanced purification technology. The entire production follows GMP, ISO, Halal, and Kosher quality systems, ensuring that every batch meets international standards and passes third-party laboratory testing for identity, purity, heavy metals, and microbial safety. Our production lines are designed to deliver stable, consistent, and scalable output for global cosmetic brands and OEM formulators.
1. Raw Material Selection
- High-grade xylose or xylose-derived intermediates are sourced from certified suppliers.
- All incoming raw materials undergo identity testing, purity checks, and contaminant screening.
2. Controlled Chemical Synthesis
- Xylose is converted into the key intermediate through a series of selective catalytic reactions.
- Reaction parameters such as temperature, pH, and pressure are tightly monitored to ensure maximum yield and molecular stability.
- This step results in a precursor molecule structurally optimized for conversion into Hydroxypropyl Tetrahydropyrantriol.
3. Functional Group Modification
- The precursor undergoes hydroxypropylation and ring modification, forming the active compound known as Pro-xylane.
- Advanced reaction control ensures a clean conversion with minimal by-products, supporting high purity.
4. Purification & Filtration
- Multiple purification stages remove impurities, unreacted intermediates, and trace solvents.
- Techniques may include fine filtration, activated carbon treatment, and fractional purification, resulting in a highly refined active ingredient.
5. Concentration & Crystallization
- The purified solution is concentrated under reduced pressure.
- Pro-xylane is crystallized into a stable white crystalline powder—the preferred form for long-term storage and bulk export.
- Crystals are washed and dried to achieve ≥99% HPLC purity.
6. Milling & Sieving
- The dried Pro-xylane crystals are milled gently to achieve uniform particle size.
- Sieving ensures smooth flowability and consistent appearance in every batch.
7. Final Drying & Stability Conditioning
- The powder undergoes controlled drying to reach the required low moisture content.
- Product is conditioned to ensure long-term stability during transport and storage.
8. Quality Control & Third-Party Testing
Each batch is tested for:
- HPLC purity (99%)
- Molecular identity
- Loss on drying
- Heavy metals & residual solvents
- Microbial limits
To guarantee safety and global compliance, samples are also submitted for independent third-party laboratory verification.
9. Packaging & Export
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Finished Pro-xylane Powder 99% is packed in double-lined aluminum bags, then sealed in 25 kg fiber drums to protect from light, moisture, and oxidation.
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Each shipment includes COA, MSDS, and full regulatory support for global export.
Pro-xylane Benefits
- Boosts glycosaminoglycan (GAG) synthesis to strengthen the skin matrix
- Improves skin firmness, elasticity, and overall density
- Enhances hydration by increasing water-binding capacity in the dermis
- Supports collagen and elastin for visible anti-aging effects
- Reduces the appearance of fine lines and wrinkles
- Helps restore skin smoothness and youthful plumpness
- Strengthens the skin barrier for long-term resilience
- Provides gentle, non-irritating anti-aging support for sensitive skin
- Increases dermal thickness for improved facial contour
- Works synergistically with hyaluronic acid, peptides, vitamin C, and niacinamide
- Delivers high bioavailability and strong dermal penetration
- Suitable for luxury serums, firming creams, eye care, and premium moisturizers
Where to buy bulk Pro-xylane Powder?
Wuxi Cima Science Co., Ltd. is the leading Pro-xylane powder manufacturer in China, supplying global skincare brands, cosmetic labs, and OEM/ODM factories with high purity 99% Pro-xylane in both powder and liquid solution forms. We offer factory-direct wholesale pricing, reliable quality, fast delivery, and complete documentation for export.
Choose Cima Science as your trusted bulk Pro-xylane powder supplier:
- China factory production a stable year-round supply
- Bulk and wholesale Pro-xylane powder 99%
- OEM services, including capsules, tablets, and Pro-xylane solution
- Free sample support for formulation testing
- Third-party testing for purity, microbial, and heavy metals
- GMP-certified production system
- Kosher and Halal certificates available
- Direct supplier with no middlemen
- Export-ready documentation, COA, MSDS, and technical data
- Competitive factory pricing for long-term partners
For the latest bulk Pro-xylane powder quotation or OEM project support, contact Cima Science’s sales team today. We deliver consistent quality, fast lead times, and premium cosmetic actives trusted by manufacturers worldwide.
