what is L-Ergothioneine?

Ergothioneine is an amino acid and thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound occurs in relatively few organisms, notably Actinobacteria (cells that resemble fungi), Cyanobacteria (photosynthetic bacteria-like cells with blue/green pigments), or some species of filamentous fungus found exclusively in the soil near termite colonies. Ergothioneine was discovered by French chemist Jules Toutant Raymond because he had been studying ergot fungi from which it was first purified due to their similarities between fungus’s structure and this new compound they found during 1909 experiments at the University de Nancy laboratory where erythrocytes were being broken down for research purposes.

Product name L-Ergothioneine Powder
Synonyms (2S)-3-(2-thioxo-2, 3-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)-propanoate;

(S)  -Carbosy-N,N,N-trimethyl-2-mercapto-1H-imidazole-4-ethanaminium inner salt; Thioneine;L(+)-Ergothioneine

Cas No 497-30-3
Molecular Formula C9H15N3O2S
Molecular Weight 229.20
Specification 99% Min
Appearance White crystalline powder
Solubility water-soluble
Benefits Anti-aging, anti-oxidant, anti-inflammatory, cell protection, skincare
Application Dietary supplements, cosmetics
Package 1kg/bag, 25kg/drum

Ergothioneine food sources

Only certain fungi and a few other microbes are currently known to be able to produce ERGO. Since mushrooms are the fruiting bodies of fungi, it is not surprising that edible mushrooms are, by far, the leading dietary source of ERGO. However, ERGO is also widespread in our food supply albeit in smaller amounts in most foods other than mushrooms.

Ergothioneine food sources

l-ergothioneine forms and specifications

Synthetic ergothioneine powder 99%

The synthesis of L-ergothioneine is performed in water and includes the following steps. First, L-hercynine is reacted with bromine and then with cysteine. The intermediate obtained is transformed into ET by heating in the presence of mercaptopropionic acid. Finally, the raw product is purified by crystallization. But it is difficult to control safety in this way. And the raw materials are expensive, so the products are sold at high prices.

Fermented ergothioneine powder 99%

The advantages of fermented ergothioneine are low cost for production and huge potential production. It’s easy to get the raw materials and has no GMO problem, no animal diseases, with good safety performance.

Ergothioneine and glutathione

Ergothioneine and glutathione are both antioxidants found in mushroom species and are highly correlated.

Ergothioneine is a powerful antioxidant that can be found in many different types of foods. It’s even more potent than glutathione when it comes to fighting free radicals, and some experts believe that Ergo levels are higher than Glutathione following ingestion from natural sources like mushrooms. Cooking these fungi does not seem to lessen their effectiveness as an anti-oxidant either!

Ergothioneine Safety

Ergothioneine is generally regarded as safe by FDA in the following products: cakes, cookies, and pastries (including granola bars); coffee; tea; fruit drinks and ades; carbonated soft drinks; and candy-containing chocolates, at a level of 5 mg ergothioneine/serving.

Ergothioneine efsa (EU laws,Reference No.1)
Synthetic l-ergothioneine (Ergoneine®) is safe as a novel food pursuant to Regulation (EC) No 258/97. L-ergothioneine is used in quantities of up to 5 mg per serving in alcohol-free beverages, cereal bars, milk, fresh dairy products, and chocolate. It’s also safe as a food supplement, with a daily dose of up to 30 mg/day for adults and 20 mg/day for children.

Ergothioneine benefits

Ergothioneine benefits


Ergothioneine as part of a healthy diet could potentially mitigate the negative effects of oxidative stress and support healthy aging by helping to preserve telomere length and reduce the rate of shortening.

Ergothioneine skincare

It is an amino acid that has fabulous results for improving the vitality of your skin. Skincare products containing ergothioneine are used to reduce signs associated with aging, such as crow’s feet, fine lines, and wrinkles.

Ergothioneine hair growth

It’s ultra-powerful antioxidant that naturally occurs in the adaptogenic fungus and has the power to deliver serious doses of nutrients straight to depleted cells that cause thinning hair.

Ergothioneine antioxidant

Ergothioneine (ESH), the betaine of 2-mercapto-L-histidine, is a water-soluble naturally occurring amino acid with antioxidant properties. ESH accumulates in several human and animal tissues up to millimolar concentration through its high-affinity transporter, namely the organic cation transporter 1 (OCTN1).

Ergothioneine and brain

Ergothioneine (ET) is a naturally occurring thiol derivative of histidine, obtained solely through diet and is able to accumulate in the body and brain, through the action of a specific transporter, OCTN1. In addition to a wide variety of in vitro and in vivo (animal) studies demonstrating the antioxidant, anti-inflammatory properties of ET, several studies have demonstrated the neuroprotective potential of ET in various cell and animal models.

Ergothioneine alzheimer’s

Ergothioneine is a natural amino acid with antioxidative properties. It prevents cellular stress, which can lead to brain diseases, neurological damage and cancer. In rats and roundworms, research shows that ergothioneine has promising effects in preventing neurodegenerative diseases such as dementia and Alzheimer’s.

Ergothioneine supplements on the market

Ergothioneine supplements

L-Ergothioneine supplement

Ergothioneine side effects

It is new to the supplement market, and there are no serious adverse effects reported yet. It should be generally safe taken according to your doctor’s advice.

Ergothioneine dosage

Most brands formulate a suggested daily dose of 5 to 10 mg of L- ergothioneine a day for adults.

Where to buy ergothioneine bulk powder?

Wuxi Cima Science Co., Ltd is a professional manufacturer with over 15-years’ experience in nutritional raw materials. We now arrange a new production schedule for it, which is our future project for health supplements.

The specifications of Cima L-Ergothioneine are 99% min, all high quality guaranteed at a good price. If you have any interests, please kindly send us an email, we will give the pricing and technical documents such as the certificate of analysis, MSDS.

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